32results about How to "Commercially viable" patented technology

The present invention provides highly pure repaglinide substantially free of dimer impurity, and process for the preparation thereof. The present invention also relates to 2- ethoxy-N-[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]-4-[2-[[(1S)-3-methyl-1-[2-(1- piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzamide, an impurity of repaglinide, and a process for preparing and isolating thereof. The present invention further relates to pharmaceutical compositions comprising solid particles of pure repaglinide substantially free of dimer impurity or pharmaceutically acceptable salts thereof, wherein 90 volume- percent of the particles (D90) have a size of less than about 400 microns. The present invention also provides an optical resolution method of racemic 3-methyl-1-(2- piperidino-phenyl)-1-butylamine and use thereof for the preparation of repaglinide.

The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of microbes and use of the peptide here disclosed as a medicament, feed additive, preservative or surfactant.

The invention discloses preparation of an antibacterial agent based on MXene quantum dots and an antibacterial activity testing method, and relates to the field of antibacterial application. Carboxylated MQDs are prepared by combining an electrochemical method and a photochemical method. Firstly, the MQDs are prepared by using the electrochemical method, and Ti3AlC2 is polymerized into Ti3C2 quantum dots in an electrolyte solution. Then, carboxylated MQDs are prepared by using the photochemical method, and hydroxyl radicals generated by H2O2 under ultraviolet irradiation react with the MQDs tofinally obtain the MQDs of which the surfaces contain a large number of carboxyl functional groups. The Ti3C2T<x> MXene quantum dots (MQDs) derived from the two-dimensional MXene material have the advantages that the excellent conductivity, temperature and chemical stability of the original MXene layered material are reserved, good water solubility, biocompatibility and low toxicity are also shown, so that the Ti3C2T<x> MXene quantum dot have a great application potential in the antibacterial field.

The invention provides a phosphorus-doped graphene quantum dot and an electrochemistry preparing method thereof. According to the preparing method, phosphorus-contained macromolecular organic compounds soluble in water are selected to serve as electrolytes, through controlled potential electrolyzing, phosphorus oxygen bonds are broken, phosphorus atoms are separated from the macromolecular organic compounds to enter the interior of the graphene quantum dot, carbon phosphorus bonds and the phosphorus oxygen bonds are formed, doping is completed, and the phosphorus-doped graphene quantum dot with the higher doping concentration content is prepared; the quantum dot has the good cleaning-up effect on hydroxyl radicals, and through ESR energy spectrum test, the clearing-up rate of the hydroxyl radicals can reach 78.49%; the method is easy and convenient in the operation process, the whole preparing process is conveniently planed as a whole, strong oxidizing acid or strong reducing agents are not used, and certain commercial feasibility is achieved; and graphene precursor which is rich in reserving and friendly to environment is adopted to replace expensive materials of graphite oxide, carbon nano-tubes and the like, and the method is hopefully and widely applied in the biomedical field.

The invention relates to the application field of fluorescence enhancement, in particular to a method for enhancing fluorescence of MXene quantum dots. The specific steps are: first make the volume fraction of 30% H 2 o 2 Add it to the MQDs solution with a concentration of 0.1 mg / mL; then ultrasonicate the MQDs solution for 4-6 minutes to mix it evenly, and name it as H-MQDs. Quantum dots (MQDs) derived from two-dimensional MXene materials not only retain the excellent electrical conductivity, temperature, and chemical stability of pristine MXene layered materials, but also exhibit good water solubility and photoluminescence properties, making MQDs ideal for bioimaging and other fields have great application potential. MQDs can be prepared by both hydrothermal and alkali reflux methods, no matter which method is used to prepare MQDs, hydrogen peroxide (H 2 o 2 ) treatment to change the surface states of MQDs, thereby enhancing their fluorescence emission ability.

The invention discloses a preparation method of icatibant acetate, which belongs to the technical field of medicine synthesis. The preparation method comprises: using a solid-phase synthesis method, sequentially connecting amino acids and dipeptide fragments with protective groups at the N-terminal and side chains to a resin solid-phase carrier according to the sequence of icatibant acetate main chain peptides, to obtain resin peptides , in which the guanidine group of arginine is protected by nitro group, and the N-terminal of glycine is connected with 2,4-dimethoxybenzyl group; the resin peptide is cleaved by a cleavage reagent, the cleaved peptide chain is separated, and the nitration is catalyzed by palladium carbon base to obtain the crude product of icatibant, which was purified to obtain icatibant acetate. The present invention uses a nitro protecting group to protect the arginine residue, which greatly reduces the synthesis cost; during the synthesis process, dipeptide fragments and skeletons are used to modify the peptide at the corresponding amino acid position, reducing the impurities of missing peptides and inserted peptides, and the preparation process is simple. , stable and commercially viable.