The invention provides a welding cast steel with a high wall thickness, which is characterized by comprising the chemical components by weight as follows: 0.07 to 0.12% of C, 0.15 to 0.40% of Si, 0.6 to 1.0% of Mn, not greater than 0.015% of S, not greater than 0.020% of P, 1.5 to 1.8% of Ni, not greater than 0.30% of Cr, 0.8 to 1.2% of Cu, and the balance of Fe and inevitable impurities. According to the cast steel, the equivalent test block with the thickness being 300 mm is subject to performance test, and the part at 1 / 4 wall based on the thickness can reach the yield strength as Rp 0.2 more than or equal to 370 MPa, and the tensile strength Rm not less than 490 MPa, and the percentage A of area reduction not less than 20%, and the percentage Z of elongation not less than 40%, and the plasticity and the toughness, specifically the low-temperature impacting toughness is superior, wherein Kv2 is more than or equal to 27J at minus 40 DEG C. The welding cast steel with high wall thickness has superior welding performance, and can carry out tailored welding among castings; and the welding cast steel with high wall thickness is suitable for building a ship structure.