46 results about "Suppository Dosage Form" patented technology

A method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, an apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

A method for treating acute ischemic stroke in a human comprises administering tenecteplase to the human in a total dose of about 0.05 to 0.5 mg / kg, given as (a) an initial bolus dose of about 0.015 to 0.15 mg / kg, followed by infusion of an amount equaling the total dose minus the initial dose over a period of about 50-90 minutes, or (b) a bolus. Also described are kits for carrying out this method.

The invention discloses a medicinal composition for treating gynecological inflammation, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and / or Chinese medicaments for releasing toxin and sterilizing such as collagen and lizardtail, glabrous greenbrier rhizome, Vietnamese sophora root and the like which are prepared into a plurality of dosage forms bycombining the prior art, and is mainly used for treating vaginitis, pelvic inflammation, urethritis and cervicitis diseases. The technical scheme overcomes the defects that the prior externally-applied preparations such as lotion, gel, suppository, ointment and the like have extremely slow response, longer disease course, repeated outbreak and the like, and creatively combines and applies the collagen and the Chinese medicament, can accelerate the healing of ulcer and erosion faces caused by the inflammation, and can greatly shorten the required time for tissue repair.

The invention relates to a controlled-release colon targeting drug adminitration preparation. The forms of the preparation are colon site-specific coated tablets or colon targeting pellets. The preparation consists of a tablet core or pellet core, an isolating layer and a controlled-release coating layer, wherein the controlled-release coating layer comprises an internal coating layer and an external coating layer. By adopting the multilayer coating technology, enteric soluble acrylic resin water dispersion and osmotic acrylic resin water dispersion are used as main coating materials for carrying out coating, thereby obtaining the controlled-release colon targeting drug adminitration preparation. The preparation of the invention enables drugs to be released at a constant rate at a colon section, realizes accurate site-specific drug release, increases the concentration of the drugs at some parts of positions with pathological changes, is beneficial to treating ulcerative colitis and carcinoma of colon, avoids the stimulation of the drugs on stomaches and small intestines, achieves the goal of colon site-specific drug release, enhances the targeting site-specific curative effect on colon diseases and reduces the toxic and side effect. Compared with the common oral preparations, under the condition of the same drug adminitration dosage, the preparation of the invention can enhance the curative effect and reduce the incidence rate of untoward reactions. Compared with the enemas or the rectal suppositories, the preparation has the advantages of uniform drug distribution in the colon and good patient compliance.

The invention relates to a pharmaceutical composition for removing dampness and relieving itching, and process for preparation, wherein the composition is prepared from cnidium fruit, goldthread root, corktree bark, Chinese dittany bark, flavescent sophora root, giant knotweed rhizome, Philippine violet herb, broom cypress fruit, knotgrass, oriental wormwood, atractylodes rhizome, pricklyash peel, borneo camphor, and can be made into the dosage forms of lotions, electuary, filming agent, liniment, suppository, aerosol, spray, externally-used tablet or effervescent tablet.

A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.

The invention relates to a medicinal composition for treating diabetic nephropathy and a preparation method thereof. The medicinal composition comprises the following raw materials in part by weight: 200 to 400 parts of radix astragali, 50 to 200 parts of rehmanniae praeparatum, 6 to 60 parts of sanchi, 20 to 100 parts of prepared rhubarb, 80 to 280 parts of euonymus alatus, 40 to 150 parts of fructus corni and 30 to 180 parts of bitter orange. The preparation method comprises the following steps: adding water into the raw materials for decoction for 1 to 4 times, adding water in an amount which is 8 to 12 times of raw materials each time; decocting the mixture for 0.5 to 2 hours, merging decoction, filtering the decoction, and decompressing and concentrating the decoction to prepare thick paste; and adding conventional auxiliary materials to prepare dosage forms such as pilula, pulvis, syrup, tablets, granules, capsules, plaster, mixtures, pills, suppositories, aerosols, ointment and the like. The medicinal composition has the effects of supplementing qi and nourishing yin, and promoting blood circulation by removing blood stasis, and has the excellent curative effect on diabetic nephropathy.

The invention relates to a compound metronidazole expansion suppository. The compound metronidazole expansion suppository is vaginal suppository prepared by metronidazole, total saponins of ginseng stems and leaves, and vitamin E which are taken as active ingredients, and proper matrix; an expandable expansion carrier is arranged in the suppository; a medicated layer formed by the active ingredients and the matrix is coated on the surface of the expansion carrier; after saturated water absorption, the expansion carrier has the radial expansion value more than 1.1. The invention also provides a detection method of the compound metronidazole expansion suppository. The method comprises the contents such as expansion value measurement, weight difference measurement, etc. The expansion suppository applies six original technologies including 'one-time suppository filling integrated forming' technology, 'inner core expansion factor control' technology, 'human engineering suppository type' technology, 'treatment-cleaning integration' dosage form, 'vaginal inner-attached administration' technology and 'side leakage prevention suppository body design'; the medicated layer of the compound metronidazole expansion suppository is fully contacted with the inner wall of the vagina, so that liquid medicine is prevented from flowing outside; the compound metronidazole expansion suppository also has the effect of cleaning the vagina so as to prevent superinfection.

The present invention relates to a suppository manufacturing method and suppository manufacturing equipment. The method comprises the simultaneous delivering of hot melt medicaments and dry cold wind with fine powder into a centrifugal spray cooling granule making machine. In this manner, medicament granules with specified diameter are prepared. The medicament granules are sent to a die and are compressed so as to get suppositories. The equipment comprises a container for hot melt medicaments and a blowing apparatus for delivering dry cold wind. The container is connected to an atomizing device at the tower top of the centrifugal spray cooling granule making machine through pipes. The blowing apparatus, connected to the centrifugal spray cooling granule making machine through the air ducts, is fit to produce swirling wind inside the centrifugal spray cooling granule making machine. A material adding device for adding fixed amount of fine powder is communicated with the air ducts. The material outlet of the centrifugal spray cooling granule making machine is connected with an oscillating sieve for sieving the medicament granules with specified diameter. According to the embodiments of the invention, the strength of the suppositories increases; the specific surface area of the suppositories enlarges; the phenomenon of layering and chromatography in the suppositories can be avoided and the outer surface of the suppositories will not have flashes.

The invention relates to a drug for treating gynecological diseases and a preparation technology thereof, belonging to the technical field of drug manufacture and including the preparation technology of the drug. The components of the main raw materials are characterized by: 30-350 parts of bark of chinese corktree, 30-350 parts of lightyellow sophora root, 20-250 parts of fructus kochiae, 10-110 parts of Hairyvein Agrimonia Herb and Bud and 1-8 parts of borneol. The raw materials are mixed to be prepared into a suppository dosage form through ethanol extraction. When in use, the active ingredients of the drug can reach the focus directly, therefore the drug has strong pertinence and concentrated acting force and causes no irritation and very little toxic or side effect to the digestive system of human body after use. The drug has few raw materials and simple preparation technology, and is proved to have rather obvious effect of treating bacterial vaginosis and colpomycosis by die pharmakodynamik experiments, as well as the functions of clearing heat and drying dampness, killing insects and relieving itching.

The present invention relates to a new gynecological Thousand-Gold preparation and its preparation method. Said new gynecological Thousand-Gold preparation not only can be used for effectively cuing female pelvic inflammation, but also can be used for effectively curing male pelvic inflammation. Said preparation can be made into various oral dosage forms, such as tublet, granules, powder, capsule and pills, etc.

The invention provides a voriconazole suppository and a preparation method and application thereof. The suppository comprises an effective dose of voriconazole, a dispersion carrier and a matrix, wherein the matrix comprises a forming agent, an emulsifying agent and a suspension aid agent. The preparation method comprises the following steps of: dissolving or dispersing voriconazole in the dispersion carrier, and uniformly mixing with the molten matrix to obtain the suppository; or adding the dispersion carrier into the molten matrix, and adding the voriconazole powder and the suspension aid agent, and uniformly mixing to obtain the suppository. The voriconazole suppository is applied to rectal or gynecological cavity administration and to the therapy for local or whole-body deep fungus infection. The invention provides a safe and effective cavity or rectal administration drug form which avoids the first-pass effect of liver, directly reaches the focus, reduces the medicine dosage, isparticularly suitable for the therapy for local deep fungus infection in gynecological cavity, pelvic cavity, accessory and the like, and ensures little side effect and good curative effect.

A vaginal tablet for treating cervicitis and cervical erosion is prepared from phellodendron bark, flavescent sophora root, catechu, baked alum and borneol. Its preparing process is also disclosed.

The present invention relates to an osmotic pump controlled-release preparation of Liuwei Dihuangwan pills or its variant prescription extract. It is characterized by that it is formed from several portions of osmotic pump tablet core, coating film and medicine-releasing hole, in which the osmotic tablet core includes 5%-70% of Liuwei Dihuang or its variant prescription active extract and 5%-90% of auxiliary material capable of making active extract be easily released. The described extract is one kind selected from Liuwei Dihuang extract, Zhibai dihuang extract, Maiwei Dihuang extract, Gouju dihuang extract, Mingmu Dihuang extract and Guifu Dihuang extract. It can be made into tablet, capsule, suppository and other dosage forms, then made into various osmotic pump preparation.s

The invention provides a drug composition for treating senile vaginitis and a preparation method thereof. The drug composition takes estriol and moxifloxacin hydrochloride as the main active ingredients, is mainly used for treating such symptoms of senile vaginitis as vaginal wall atrophy, mucosa thinning, local resistance decrease and inflammations caused by bacteria invasion and reproduction and has the functions of recovering the activity of the vaginal epithelial cell and suppressing growth and reproduction of bacteria in the vagina. The drug composition is used for preferably preparing such dosage forms for intravaginal administration as suppositories, gels and ointments.

The invention relates to a split type suppository as well as a preparation method and a use thereof. The split type suppository comprises a suppository body with a groove and an expansion carrier which is mutually separated from the suppository body, wherein the suppository body mainly comprises active ingredients and a matrix; the groove is composed of a groove side wall and a groove bottom; the diameter of the cross section of the groove is 1 / 3-2 / 3 that of the cross section of the suppository body; and the length of the groove is 1 / 5-4 / 5 the length of the suppository body. The split type suppository provided by the invention not only can avoid the examination and approval of the drug administration agencies, but also can refrain the expansion carrier from adsorbing the active ingredients and the matrix in the suppository body due to splitting of the suppository body and the expansion carrier.

The invention relates to a pharmaceutical composition for removing dampness and relieving itching, and process for preparation, wherein the composition is prepared from cnidium fruit, goldthread root, corktree bark, Chinese dittany bark, flavescent sophora root, giant knotweed rhizome, Philippine violet herb, broom cypress fruit, knotgrass, oriental wormwood, atractylodes rhizome, pricklyash peel, borneo camphor, and can be made into the dosage forms of lotions, electuary, filming agent, liniment, suppository, aerosol, spray, externally-used tablet or effervescent tablet.

The invention discloses a hemorrhoid suppository filling liquid medicine stirring and mixing device. The hemorrhoid suppository filling liquid medicine stirring and mixing device comprises a mountingshaft, a top cover, a stirring kettle, a first conveying pipe, a first pressure pump, a collecting box, a heater, a heating coil and supporting legs; the mounting shaft is provided with a spiral bladefor spirally and upwards conveying and stirring liquid medicine in the stirring kettle; a motor for driving the mounting shaft to rotate is arranged on the top cover; an input end of the first pressure pump is connected with the first conveying pipe, and an output end is connected with the collecting box; a discharging pipe is arranged on the collecting box; a first control valve is arranged on the first conveying pipe; the end, away from the first pressure pump, of the first conveying pipe is communicated with the stirring kettle through a discharging hole; the heating coil is spirally arranged on the outer peripheral surface of the stirring kettle and is connected with the heater; the supporting legs are arranged at the bottom of the stirring kettle. The spiral blade is used for stirring medicine powder and a matrix, the medicine powder and the matrix are spirally conveyed upwards from the middle of the stirring kettle and scattered at the top of the stirring kettle, the medicine powder in the stirring kettle is uniformly dispersed, and the medicine powder can be uniformly mixed with the matrix.

The invention discloses a filling system and method of a suppository filling and sealing machine. The filling system comprises an adjusting chamber, a storage mechanism is fixedly installed at the top of the adjusting chamber, a filling mechanism is fixedly installed at the top of the inner wall of the adjusting chamber, the filling mechanism is arranged below the storage mechanism, conveying mechanisms are arranged on the inner walls of the two sides of the adjusting chamber, a sealing cover mechanism is rotationally installed at the top of the adjusting chamber, the storage mechanism comprises a storage chamber, and a pushing air cylinder is fixedly installed at the top of the outer wall of the storage chamber. According to the filling system and method of the suppository filling and sealing machine, through the cooperative design of a hollow plate, side sliding plates, a connecting roller and a telescopic spring, when the hollow plate and the side sliding plates enter the lower half part of the storage chamber, the two side sliding plates can slide in opposite directions, and materials are continuously pushed downwards; and through the arrangement of the telescopic spring, after the hollow plate rises, the telescopic spring can push the side sliding plates back to the original positions in time, and the technical problem that when the lower half part of the storage chamber is of a conical structure, the materials cannot be continuously pushed downwards is solved.

The invention discloses a traditional Chinese medicine suppository for treating metrorrhagia and metrostaxis, which is prepared by the following main raw materials in parts by weight: 2-6 parts of raw sabinene, 4-9 parts of radix sophorae flavescentis, 8-20 parts of chinese osbeckia, 3-9 parts of fructus malvae, 4-9 parts of cuttlefish bone, 3-9 parts of fructus cnidii, 0.5-1.2 parts of red upborne elixir, 9-12 parts of fructus leonuri, and 30-60 parts of oleum sesami. The traditional Chinese medicine suppository has the effects of invigorating qi and blood, activating the blood circulation to dispel blood stasis, as well as stopping bleeding and regulating menstruation, and has a good treatment effect on the metrorrhagia and metrostaxis; the dosage form is suppository which can play local roles in lubricating, antibiosis, insect killing, convergence, pain stopping, itching relieving and other local roles in an orifice, and can also avoid the stimulation of drug on a gastric mucosa, and cannot have any toxic and side effect to a patient.

The present invention discloses a blumea balsamifera volatile oil suppository and a preparation process thereof, wherein the components of the suppository at least comprise blumea balsamifera volatile oil and an auxiliary material. The preparation process comprises: preparing blumea balsamifera volatile oil; adding an auxiliary material to the blumea balsamifera volatile oil, and carrying out water bath heating melting; and filling into a suppository mold, curing, and demolding. According to the present invention, the blumea balsamifera plant resource is rich, the material is easy to obtain, and the cost is low; the blumea balsamifera volatile oil suppository reaches the affected area through the local action, and has characteristics of long residence time, rapid efficacy providing, good bioavailability, first pass effect reducing, toxic-side effect reducing, and good efficacy obtaining; the blumea balsamifera volatile oil suppository preparation process is simple, and is suitable for industrialization; the blumea balsamifera volatile oil suppository has characteristics of wide application people, good patient compliance, a certain economic and social benefit, and the like; and the blumea balsamifera volatile oil suppository provides good research basis for the development of new traditional Chinese medicine dosage forms for treatment of gynecological vaginitis and other diseases, and provides a certain promotion effect for the traditional Chinese medicine modernization and international development.

The traditional Chinese medicine composition for treating irritable bowel syndrome includes: 15-30 grams of Atractylodes macrocephala, 8-25 grams of white peony root, 5-20 grams of tangerine peel, and 5-20 grams of Fangfeng. Or: volatile oil components of Atractylodes macrocephala, tangerine peel and Fangfeng; ethanol extraction components of Atractylodes macrocephala, tangerine peel, Fangfeng, and white peony root; appropriate amount of vegetable oil. Prescriptions can be directly used clinically, or after addition and subtraction. Its preparation method: take Atractylodes macrocephala, tangerine peel and Fangfeng, add water to soak, extract and collect volatile oil, and filter the medicinal solution; add ethanol to the medicinal residue and white peony root, soak, extract, and filter; the above two filtered solutions are combined and concentrated to obtain an extract , add volatile oil and vegetable oil, mix well, that is. Soft capsules and soft capsule dosage forms made by soft capsule molding process have the advantages of rapid disintegration, high bioavailability, good stability, beautiful appearance, easy to carry, easy to take, etc. Hard capsules, granules, Common dosage forms such as tablets, oral liquids, and suppositories also have the above advantages.

The invention relates to the technical field of medicines and in particular relates to a carbazochrome sodium sulfonate semisolid preparation and a preparation method thereof. The preparation method comprises the following steps: with high-purity carbazochrome sodium sulfonate with the purity above 99.80 percent as an active ingredient, adding a medical matrix to prepare one of suppository, ointment and gel; wherein every10g of the suppository contains 20-80mg of carbazochrome sodium sulfonate; the ointment per 10g contains 40-80mg of the carbazochrome sodium sulfonate; every 5g of the gel contains 40-80mg of the carbazochrome sodium sulfonate. According to the carbazochrome sodium sulfonate semisolid preparation and the preparation method disclosed by the invention, the purity of the carbazochrome sodium sulfonate serving as the active ingredient is above 99.80 percent and by-products are controlled to be below 0.2 percent; when the carbazochrome sodium sulfonate semisolid preparation is used, the adverse reaction incidence in the medication process can be lowered and the medication safety can be improved; meanwhile, the prepared carbazochrome sodium sulfonate semisolid preparation can be delivered by virtue of body cavities so that the high-purity carbazochrome sodium sulfonate is capable of improving the medication safety while high bioavailability of a product is ensured.

The invention discloses a prostatitis pad plaster, which belongs to the technical field of a medical plaster. The prostatitis pad plaster comprises the following raw materials in parts by weight: 30-80 parts of raspberry, 20-50 parts of plantago, 40-60 parts of dianthus superbus, 35-60 parts of polygonum aviculare, 30-60 parts of Sichuan achyranthes, 40-55 parts of Pyrrosia lingua, 38-48 of Lygodium japonicum, 20-60 parts of polyporus, 45-55 parts of dandelion, 40-60 parts of Semen Astragali Complanati, 30-60 parts of fructus rosae laevigatae, 30-68 parts of saururus chinensis, 40-55 of SemenCuscutae, and 10 to 100 parts of borneol. The prostatitis pad plaster prepared by the invention is applied in a manner that avoids the discomfort of a gel, a suppository, an umbilical paste, a physiotherapy instrument, and other external products, and the side effects caused by the medication. The prostatitis pad plaster is safer, more comfortable, non-invasive, and painless, has no side effects,and has rehabilitation and physiotherapy on prostatitis, prostate hypertrophy syndrome.

The invention relates to the technical field of medicine manufacturing, and concretely relates to a nifuratel nystatin suppository manufacturing method and equipment. Primary suppositories prepared by a centrifugal spray granulator are conveyed into a cloth bag, air is supplied into a drying box through an air supply assembly to dry the primary suppositories, after drying is completed, a first electric push rod is started to make the cloth bag protrude, and the dried suppositories fall into a collection hopper under the action of gravity and then are conveyed into a screening box, and the suppositories which do not conform to specifications and sizes are screened out through a first screening mechanism and a second screening mechanism in sequence, so that finished suppositories are obtained. Compared with a traditional mode that all procedures are independently arranged, the manual intervention degree is high, the structure is highly integrated, the manual intervention degree is low, and the suppository preparation efficiency is improved.

The invention refers to a chloramphenicol vaginal soft capsule. The content of the soft capsule is composed of the following components by weight proportion: 50-200g of chloramphenicol; 140-560g of 1.2-propylene glycol and 60-240g of polyethelene glycol 600; the formula of gelatin liquid is that gelatin: glycerol: water is equal to 0.5-1.5:0.4-0.6:0.5-1.5; the preparation method and the formula are scientific and precise, and the dosage form is novel. Compared with suppository, the soft capsule is characterized by higher bioavailability, accurate content, good uniformity and beautiful appearance, which is especially applied to the treatment of bacterial vaginitis, trichomonal vaginitis, colpitis mycotica and senile vaginitis.

The invention discloses a staphylococcus aureus bacteriophage suppository and application thereof in treatment of dairy cows. The suppository is prepared from the following raw materials in percentage by mass: 25-75% of a water-soluble matrix, 1-4% of a bacteriophage stock solution, 5-10% of an effervescent disintegrant, 10-35% of a lubricant, 1-3% of a foaming agent, 1-2% of resveratrol and 2-5% of traditional Chinese medicine auxiliary materials. The effervescent suppository has the beneficial effects that the effervescent suppository, the resveratrol and a plurality of traditional Chinese medicine auxiliary materials are matched, and the synergistic or antagonistic effect of the effervescent suppository, the resveratrol and the traditional Chinese medicine auxiliary materials is utilized, so that the curative effect can be effectively improved or the adverse reaction can be reduced, the effects of clearing heat and promoting diuresis, promoting blood circulation and removing blood stasis, and sterilizing and diminishing inflammation can be achieved, and the symptom of dairy cow uterus bacterial vaginitis can be quickly relieved; and the medicine is low in cost, does not cause economic burden after being used for a long time, and is an ideal medicine for treating bacterial vaginitis.

The invention relates to a composition comprising a mixture of Saccharomyces boulardii yeast cells and a wax.

The invention provides a medical biological dressing suppository for treating gynecological diseases, diseases of prostate or anorectal diseases and an application thereof. The medical biological dressing suppository comprises a main drug and auxiliary materials. The main drug comprises echinacea and chitosan. According to the invention, echinacea is applied to an external medicine for the first time. Relative to internal medicines, the external medicine can directly reach the diseased region with a small dosage, so that a better treatment effect is realized. Even though echinacea is mutually fused with chitosan and is adsorbed to the affected skin or the surface of mucosa to form a protective layer, synergic effects of maintaining effective delivery concentration to echinacea and prolonging the action time of the medicine and the like are obtained by means of good biocompatibility of chitosan. In addition, echinacea adsorbed to the affected skin or the surface of mucosa further can effectively stimulate generation of glucosaminidase and growth of myofibroblast to enhance the defense capacity of the skin or mucosa. Echinacea purpurea further can simulate the immune system, increase the quantity and activity of leukocytes and enhance the treatment effect of independent medication.