Compound metronidazole expansion suppository, preparation technology and detection method thereof

Abstract

The invention relates to a compound metronidazole expansion suppository. The compound metronidazole expansion suppository is vaginal suppository prepared by metronidazole, total saponins of ginseng stems and leaves, and vitamin E which are taken as active ingredients, and proper matrix; an expandable expansion carrier is arranged in the suppository; a medicated layer formed by the active ingredients and the matrix is coated on the surface of the expansion carrier; after saturated water absorption, the expansion carrier has the radial expansion value more than 1.1. The invention also provides a detection method of the compound metronidazole expansion suppository. The method comprises the contents such as expansion value measurement, weight difference measurement, etc. The expansion suppository applies six original technologies including 'one-time suppository filling integrated forming' technology, 'inner core expansion factor control' technology, 'human engineering suppository type' technology, 'treatment-cleaning integration' dosage form, 'vaginal inner-attached administration' technology and 'side leakage prevention suppository body design'; the medicated layer of the compound metronidazole expansion suppository is fully contacted with the inner wall of the vagina, so that liquid medicine is prevented from flowing outside; the compound metronidazole expansion suppository also has the effect of cleaning the vagina so as to prevent superinfection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a compound metronidazole expansion suppository and a detection method thereof. Background technique [0002] Compound metronidazole suppository is the drug used for the treatment of senile vaginitis, trichomonal vaginitis and non-specific vaginitis recorded in "Ministry of Health's New Drug Standards" (Volume 11) published in 1997. Vaginal suppositories made of nitrazole, ginseng stem and leaf saponins, vitamin E, Tween-80, polyethylene glycol 4000, polyethylene glycol 400 and water, the formula and process of compound metronidazole suppositories were also applied for in the same year Chinese patent CN97100656, Chinese patent CN97116897 record. The compound metronidazole suppository has the following inherent defects: 1. It is not easy to clean, and it is easy to contaminate clothes; 2. The contact surface between the active drug and the human body is small, resulting in ins...

AI Technical Summary

Problems solved by technology

The compound metronidazole suppository has the following inherent defects: 1. It is not easy to clean, and it is easy to contaminate clothes; 2. The contact surface between the active drug and the human body is small, resulting in insufficient absorption, and the best curative effect of the prescription is not exerted.

But, the clinical trials of Compound Metronidazole Effervescent Tablets and Compound Metronidazole Soft Capsules have not reached the expected effect. Therefore, try to improve the existing Compound Metronidazole suppository, and formulate a scientific formula in order to control the stability of product quality. Detection method, an urgent task for the prior art field

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