Compound chloramphenicol vaginal swelling suppository, as well as preparation method and detection method thereof
A vaginal expansion suppository, chloramphenicol technology, applied in the directions of suppository delivery, pharmaceutical formulations, material inspection products, etc., can solve the problems of easily contaminated clothing, irritation, unstable properties, etc., to avoid secondary infection and prevent outflow. Effect
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Embodiment 1
[0106]
[0107] Preparation:
[0108] 1) Preparation of drug-containing matrix:
[0109] a. Anise fat and beeswax are placed in a water bath for heating and melting to obtain a melt;
[0110] b. mix chloramphenicol, boric acid, vitamin A and vitamin D2, add in the melt of step a, mix well, make the matrix containing medicine;
[0111] 2) Preparation of expansive suppositories: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 spherical suppositories, each weighing about 1.8g.
Embodiment 2
[0113]
[0114] Preparation:
[0115] 1) Preparation of drug-containing matrix:
[0116] a. heating and melting the semi-synthetic fatty acid glyceride in a water bath to obtain a melt;
[0117] b. mixing chloramphenicol, boric acid, vitamin A and vitamin D2 with sucrose monolaurate and sodium stearyl fumarate to prepare the first mixture;
[0118] c. adding the first mixture to the melt in step a, and mixing evenly to obtain a drug-containing matrix;
[0119] 2) Preparation of expansive suppositories: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 cylindrical suppositories, each weighing about 5.0 g.
Embodiment 3
[0121]
[0122]
[0123] Preparation method: make 100 rod-shaped suppositories according to the method in Example 2, each weighing about 3.5g.
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