The invention provides a manufacturing process of a pump body casting of a super duplex stainless steel centrifugal pump. The manufacturing process comprises steps of sand mould prefabricating, material smelting, casting, sand shakeout and heat treatment, wherein a runner core in a sand mould is composed of chromite furan resin sand of which the outer layer is filled with quartz furan resin sand;in material smelting, super duplex stainless steel material ZG00Cr25Ni7Mo4N is used, the chemical composition, ferrite content and PREN (Pitting Resistance Equivalent) value of molten steel are undercontrol and the casting temperature is from 1540 DEG C to1560 DEG C; after sand shakeout, forced air cooling is carried out, spray cooling is further carried out on the thick and large part of the casting, and after a casting system and a dead head are removed, the heat treatment is carried out. The pump body casting of a super duplex stainless steel centrifugal pump, which is manufactured by using the manufacturing method, has the advantages that the manufacturing and maintenance cost is reduced, abrasion resistance and pitting resistance are improved and the service life is prolonged.