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Vagina tablet for treating cervicitis, cervical erosion, and preparation method

A technology for cervical erosion and vaginal tablets, applied in the field of traditional Chinese medicine preparations, can solve the problems of reducing the practical application value and clinical efficacy of Zhimiling suppository, easy melting and deformation of suppository matrix, shortening of drug retention time, etc. Reasonable and feasible effect of retention time and preparation process

Inactive Publication Date: 2007-05-09
哈尔滨儿童制药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since it was launched on the market, it has achieved reliable curative effect in the treatment of cervical erosion in women, but according to the general reflections of clinicians and patients, the dosage form still has the following shortcomings: First, Zhimiling suppository is easy to flow out of the vagina with the excipient after the vagina melts, As a result, the retention time of the drug is shortened, which not only affects the curative effect of the drug, but also pollutes the underwear, causing most patients to use it inconveniently; the second is that the suppository base is easily melted and deformed at about 36°C, which affects its use and preservation, especially in hot summer. use and storage
3. Its clinical curative effect is still not definite enough and needs to be further improved
Due to the existence of the above-mentioned defects, the practical application value and clinical curative effect of "Zhimi Ling Suppository" have been reduced.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] [embodiment 1] preparation of tablet of the present invention

[0023] Weigh each raw material according to the following weight: Phellodendron 500g, Sophora flavescens 500g, Catechin 500g, Dry alum 400g, Borneolum 100g; The above five flavors, Catechin and dry alum are crushed into powder, Borneolum is ground into fine powder, Phellodendron and Kushen are added to water and decocted Three times, 2 hours for the first time, 1 hour for the second and third times, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the ethanol content in the solution 75%, let it stand for precipitation, and take the supernatant for recovery Ethanol, concentrated to a thick paste, mixed with the above-mentioned dried alum and catechin fine powder, added 100g sodium starch glycolate and 60g starch, mixed evenly, made granules with 5% povidone K30 ethanol solution, dried, and borneol fine powder Add 100g of starch and mix evenly with the abov...

Embodiment 2

[0024] [embodiment 2] preparation of tablet of the present invention

[0025] Weigh each raw material according to the following weight: Phellodendron 500g, Sophora flavescens 500g, Catechin 500g, Dry alum 400g, Borneolum 100g; The above five flavors, Catechin and dry alum are crushed into powder, Borneolum is ground into fine powder, Phellodendron and Kushen are added to water and decocted , combine the decoction, filter, concentrate the filtrate to an appropriate amount, add ethanol, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a thick paste, mix with the above-mentioned dry alum and catechin fine powder, add carboxymethyl starch Mix 50g of sodium and 30g of starch, make granules with 5% povidone K30 ethanol solution, dry, add 100g of borneol fine powder and mix with the above granules, add 20g of microcrystalline cellulose, cross-linked polyvinylpyrrolidone 10g is mixed evenly, added with 0.8% magnesium stearate (amount of ≤ 1%), m...

Embodiment 3

[0026] [embodiment 3] preparation of tablet of the present invention

[0027] Weigh each raw material according to the following weight: Phellodendron 500g, Sophora flavescens 500g, Catechin 500g, Dry alum 400g, Borneolum 100g; The above five flavors, Catechin and dry alum are crushed into powder, Borneolum is ground into fine powder, Phellodendron and Kushen are added to water and decocted , combine the decoction, filter, concentrate the filtrate to an appropriate amount, add ethanol, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a thick paste, mix with the above-mentioned dry alum and catechin fine powder, add carboxymethyl starch Mix 150g of sodium and 100g of starch, make granules with 5% povidone K30 ethanol solution, dry, add 100g of borneol powder and mix with the above granules, add 90g of microcrystalline cellulose, cross-linked polyvinylpyrrolidone Mix 80 g, add 0.8% magnesium stearate (amount of ≤ 1%), mix evenly, and press ...

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PUM

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Abstract

A vaginal tablet for treating cervicitis and cervical erosion is prepared from phellodendron bark, flavescent sophora root, catechu, baked alum and borneol. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a vaginal tablet, in particular to a vaginal tablet for treating cervicitis and cervical erosion and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Cervicitis and cervical erosion are common and frequently-occurring diseases in gynecological clinics. The incidence rate accounts for more than 50% of married women. In recent years, the incidence rate has increased and the age of onset has advanced. Because its illness is lingering, it is not easy to recover, it has brought great inconvenience to the life and work of the majority of women comrades, and has greatly affected the physical and mental health of the majority of women. There are many literature reports that the incidence of cervical cancer is closely related to cervical erosion. Therefore, the treatment of cervical erosion is the main measure to prevent cervical cancer. [0003] Cervical e...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K31/045A61K33/06A61K9/20A61P15/00
Inventor 房凯
Owner 哈尔滨儿童制药厂有限公司
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