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95 results about "Acute ischemic stroke" patented technology
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Devices and methods for embolus removal during acute ischemic stroke
Devices, methods, and systems facilitate and enable treatment of ischemic stroke. More specifically, a tethered basket-like system operates in conjunction with a microcatheter system, to provide arterial support and capture emboli.
Owner:TYCO HEALTHCARE GRP LP
Method for providing progressive therapy for thrombus management
ActiveUS20110160742A1Avoid damageFacilitates natural lysisStentsIncision instrumentsLysisDistal embolization
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and / or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
Owner:TYCO HEALTHCARE GRP LP
Method of treating stroke with thrombolytic agent
A method for treating acute ischemic stroke in a human comprises administering tenecteplase to the human in a total dose of about 0.05 to 0.5 mg / kg, given as (a) an initial bolus dose of about 0.015 to 0.15 mg / kg, followed by infusion of an amount equaling the total dose minus the initial dose over a period of about 50-90 minutes, or (b) a bolus. Also described are kits for carrying out this method.
Owner:GENENTECH INC
Non-invasive reperfusion system by deformation of remote, superficial arteries at a frequency much greater than the pulse rate
InactiveUS20130281897A1Effective researchEffective clinical toolUltrasound therapyOrgan movement/changes detectionPULMONARY EMBOLUSThrombus
Preferred systems for assisting clearance of an acutely thrombosed artery substantially surrounded by boney external body surfaces which are resistant to deformative displacement relative to the thrombosed artery by the application of external percussive force are described. The method consists of applying targeted, localized, non-invasive, high infrasonic to low sonic frequency vibratory percussion with a serial impact frequency much greater than the pulse rate of a patient being treated, the percussion directed towards a remote, preferably superficial “target vessel” residing palpably close to the skin surface. Marked vessel deformations with resultant blood pressure and flow fluctuations are thereby induced by the percussion within the target vessel which propagate to the acutely thrombosed artery to provide localized agitation and turbulence to assist thrombolytic and / or IV microbubble delivery and effectiveness in facilitating reperfusion. Preferred apparatus for treatment of ST elevation myocardial infarction, acute ischemic stroke and acute pulmonary embolus are presented.
Owner:AHOF BIOPHYSICAL SYST
Thrombus management device
InactiveUS20120041475A1Facilitate natural lysis and fragmentationRestore blood flowStentsIncision instrumentsLysisDistal embolization
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and / or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and / or removal.
Owner:TYCO HEALTHCARE GRP LP
Method of treating stroke with thrombolytic agent
A method for treating acute ischemic stroke in a human comprises administering tenecteplase to the human in a total dose of about 0.05 to 0.5 mg / kg, given as (a) an initial bolus dose of about 0.015 to 0.15 mg / kg, followed by infusion of an amount equaling the total dose minus the initial dose over a period of about 50-90 minutes, or (b) a bolus. Also described are kits for carrying out this method.
Owner:GENENTECH INC
Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia
InactiveUS20060276455A1Influence permeabilityIncrease the number ofBiocideAnimal repellantsCardiorespiratory arrestSubarachnoid hemorrhage
The invention concerns the use of a mast cell activation- or degranulation-blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia. The invention also relates to treatment of patients suffering from acute ischemic stroke, acute hemorrhagic stroke, subarachnoid hemorrhage, cerebral venous thrombosis or global cerebral ischemia associated with cardiac arrest. Further, the invention provides compositions of contrast media or similar exogenous media, which are intended for use in diagnostic or therapeutic applications for introduction into the intravascular, intrathecal or the intracranial space, comprising a mast cell degranulation-blocking and / or mast cell activation-blocking agent.
Owner:LICENTIA OY
Vibration method for clearing acute arterial thrombotic occlusions in the emergency treatment of heart attack and stroke
InactiveUS8870796B2Improve efficiencyImprove vibrationUltrasound therapyOrgan movement/changes detectionEmergency treatmentThrombotic occlusion
Owner:PARALLEL BIOTECH LLP
Method and device for segmenting cerebral ischemia areas in diffusion-weighted images
ActiveCN108122221AImprove Segmentation AccuracyResolve identifiabilityImage enhancementImage analysisSupport vector machineFeature vector
The invention provides a method and device for segmenting cerebral ischemia areas in diffusion-weighted images. The method comprises the following steps of: dividing diffusion-weighted images of a plurality of super-acute ischemic stroke patients into test images and training images; training a random forest model, a learning dictionary and a support vector machine model according to the trainingimages; carrying out initial cerebral ischemia area segmentation by utilizing the trained random forest model according to grey features of voxels in the test images; determining a sparse encoding matrix of a local image block feature vector of each voxel in connected regions on the basis of the trained learning dictionary; and classifying each connected area by utilizing the trained linear support vector machine model according to a package feature of each connected area, and deleting the connected areas, in which non-ischemic tissues are located, from a first initially segmented image so asto obtain an optimal segmented image. According to the method and device, automatic recognition and segmentation of super-acute cerebral ischemia areas can be solved, and the ischemia area segmentation precision is improved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Antithrombotic Neurovascular Device Containing a Glycoprotein IIB/IIIA Receptor Inhibitor for The Treatment of Brain Aneurysms and/or Acute Ischemic Stroke, and Methods Related Thereto
InactiveUS20100280594A1Preventing thromboembolismPrevent thrombosisStentsPharmaceutical containersWhole bodyThrombus
Disclosed is an antithrombotic neurovascular device useful for the treatment of brain aneurysms and / or acute ischemic stroke. The device comprises a mechanical structure, which may be a stent, stent-like structure, or flow diverter, and a drug-eluting coating. This device is designed for local delivery of antiplatelet medication to the site of device implantation in order to improve outcomes for the population of brain aneurysm and / or acute ischemic stroke patients currently being treated with stents, and for use with patients presenting with ruptured aneurysms, in whom systemic dual antiplatelet therapy is contraindicated. The coating comprises an antiplatelet drug, preferably, a GPIIb / IIIa receptor inhibitor, more preferably, abcixmab, and optionally comprises a polymeric binder that functions as a drug modulating polymer. Also disclosed are methods for producing the antithrombotic neurovascular device, and using the device for the treatment of brain aneurysms and / or acute ischemic stroke.
Owner:MEDISOLVE
Biomarkers for acute ischemic stroke
ActiveUS20130189243A1Convenient treatmentAdditional diagnostic and/or prognostic indicatorsPeptide librariesPeptide/protein ingredientsBiomarker (petroleum)Ischemic stroke
The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.
Owner:UNITED STATES OF AMERICA +1
Systems And Methods For Deciding Management Strategy in Acute Ischemic Strokes Using Rotational Angiography
InactiveUS20190117179A1Rapid diagnosisQuick treatmentHealth-index calculationSurgeryRisk strokePatient status
The invention relates to systems and methods for diagnosing strokes. In particular, systems and methods for acquiring timely patient status information are described that enable a physician to make diagnostic and treatment decisions relating to strokes. The systems and methods enable the efficient and quantitative assessment of arterial collaterals within the brain for aiding these decisions in the case of ischemic strokes.
Owner:MG STROKE ANALYTICS INC
A method and apparatus for image region segmentation of ischemic stroke
ActiveCN109242863AEffective segmentationAvoid errorsImage enhancementImage analysisImage segmentationCerebral infarction
A method and apparatus for image region segmentation of ischemic stroke are disclosed. The method comprises the following steps: preprocessing the CTP sequence diagram of the first intracranial computed tomography perfusion imaging to obtain the CTP sequence diagram of the intracranial after preprocessing; Inputting the preprocessed intracranial CTP timing diagram into a first network for processing to obtain a first nuclear magnetic resonance MRI image corresponding to the preprocessed intracranial CTP timing diagram; inputting the first MRI image into a second network for processing to obtain a region segmentation image of ischemic stroke. A corresponding device is also disclosed. Through a series of convolution operations on the CTP timing diagram, the CTP timing diagram is automatically and efficiently divided into cerebral infarction region, penumbra region and background region. The whole process does not require manual participation, which can effectively avoid the error causedby manual participation, save human cost, and can efficiently and fast complete the CTP timing diagram distinction.
Owner:BEIJING SENSETIME TECH DEV CO LTD
Aspilrin slow release tablet
A slow-releasing aspirin table for treating acute ischemic apoplexy and cerebrovascular and cardiovascular diseases is prepared from aspirin and auxiliaries through proportionally mixing hydroxypropyl methylcellulose, polyacrylic resin II and aspirin, mixing with the solution of hydroxypropyl methylcellulose in alcohol to obtain soft material, granulating by nylon sieve, drying, and loading in capsules, or further mixing with talc powder and tabletting. Its advantages are stable concentration in blood and durable curative effect.
Owner:郑州市协和制药厂
Application of lncRNA (long non-coding ribonucleic acid) to diagnosing cerebral ischemic stroke
ActiveCN106319089AImprove accuracyMicrobiological testing/measurementDNA/RNA fragmentationIschemic brainAcute ischemic stroke
The invention discloses application of lncRNA (long non-coding ribonucleic acid) to diagnosing cerebral ischemic stroke. The lncRNA is LOC101929707. The application has the advantages that correlation between LOC101929707 genes and occurrence and development of the cerebral ischemic stroke is discovered, and accordingly the LOC101929707 can be used as a possible detection target to be applied to early diagnosing the cerebral ischemic stroke on the basis of the correlation.
Owner:THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIV MEDICAL COLLEGE
Analyzing and processing method for analyzing and processing magnetic resonance image of acute ischemic stroke
ActiveCN105787918AAccurate segmentationImprove Segmentation AccuracyImage analysisCharacter and pattern recognitionFeature vectorPositive sample
The invention provides an analyzing and processing method for analyzing and processing the magnetic resonance image of the acute ischemic stroke the method specifically comprises the steps of according to the data of a magnetic resonance image, acquiring the data of the magnetic resonance image, conducting the gold standard treatment on the data of the magnetic resonance image, setting the data of the image after the gold standard treatment as a positive sample set, obtaining a negative sample based on the data of the image after the gold standard treatment, obtaining a negative sample based on the data of the image in an initial ischemic region, obtaining a negative sample set, extracting the feature vectors of the positive sample set and the negative sample set, combining the extracted feature vectors as a training dictionary, obtaining to-be-segmented voxels based on the data of the image in an initial ischemic candidate region, and judging whether to-be-segmented voxels are ischemic voxels or not according to the training dictionary. According to the technical scheme of the invention, based on the analyzing and processing method for analyzing and processing the magnetic resonance image of the acute ischemic stroke, an ischemic region can be segmented more accurately. Meanwhile, the segmentation accuracy is high and the influence of noises or artifacts is small.
Owner:SHENZHEN INST OF ADVANCED TECH
Biomarkers for acute ischemic stroke
ActiveUS9200322B2Convenient treatmentAdditional diagnostic and/or prognostic indicatorsPeptide librariesPeptide/protein ingredientsRisk strokeBiomarker (petroleum)
The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.
Owner:UNITED STATES OF AMERICA +1
Acute ischemic stroke focus automatic segmentation method and system, terminal and medium
PendingCN113077479AAccurate segmentationImprove performanceImage enhancementImage analysisVoxelFeature Dimension
The invention discloses an acute ischemic stroke focus automatic segmentation method and system. The method comprises the following steps of: registering a head CT (Computed Tomography) image; removing the skull to obtain a brain parenchyma three-dimensional mask; performing ellipse fitting on the brain parenchyma three-dimensional mask through PCA feature dimension reduction to obtain median sagittal plane data; calculating left and right symmetric parameter diagrams of the brain; setting different window widths and window levels for the median sagittal plane data to obtain multi-level window width and window level image data; marking training data; training a segmentation convolutional neural network model; inputting test data into the trained segmentation model for segmentation to obtain a segmentation probability graph of the brain parenchyma, the cerebrospinal fluid and the stroke focus of the corresponding voxel and a prediction probability of whether the stroke focus exists in the corresponding two-dimensional image; and outputting different segmentation results according to different prediction probabilities. According to the method, multi-task training is carried out in combination with brain anatomy priori knowledge, the performance of the convolutional neural network in the NCCT stroke focus automatic segmentation method is improved, and the acute ischemic stroke focus can be accurately segmented.
Owner:深圳市铱硙医疗科技有限公司
Transcranial laser therapy for treatment of acute ischemic stroke
ActiveUS20190070431A1Level of easeIncrease exposureLighting heating/cooling arrangementsPrinted circuit aspectsLighting spectrumLight-emitting diode
An apparatus and method of use for a comprehensive transcranial low-level light therapy for use with ischemic brain tissue using a multitude of polychromatic Light Emitting Diodes (LEDs) embedded into a flexible head covering that stretches securely around the patient's cranium to bath the entire cranium cavity in a variable frequency, variable power density light spectrum, maximizing all beneficial effects to the cellular tissues whether or not they are specifically deprived of blood from the ischemic stroke event. The bulbs covering the n-p junction of the semiconductor LEDs directly contact the patient's cranial skin to maximize the depth of penetration of the wavelengths into the brain's cortex cells. By using many individual point-source LEDs emitting all around the cranium, greater therapeutic benefit can be achieved as more of the cortex tissues are irradiated.
Owner:ZIVIN RENI ZOE
Compositions and methods for treatment of stroke and other CNS disorders
InactiveUS20200255530A1Pharmaceutical delivery mechanismImmunoglobulins against cell receptors/antigens/surface-determinantsDiseaseArachnoids
The invention relates to methods of treating stroke comprising administration of a VLA-4 antagonist to a subject after the onset of the stroke, e.g., ischemic stroke (e.g., acute ischemic stroke) or hemorrhagic stroke (e.g., intracerebral hemorrhage), sub-arachnoid hemorrhage, or traumatic brain injury. Kits and articles of manufacture are also described herein.
Owner:BIOGEN MA INC
Use of racemates of pinocembrin in preparing medicaments for treating stroke
Use of a racemate of pinocembrin, a racemate of pinocembrin salt, a racemate of pinocembrin precursor or a racemate of pinocembrin hydrate in manufacture of a medicament for prophylaxis and treatment of stroke. Particularly, use of pinocembrin racemate in manufacture of a medicament for treatment of acute ischemic stroke.
Owner:CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy
ActiveCN101744806AImprove behavioral changesDecreased cerebral blood flowOrganic active ingredientsCardiovascular disorderMedicinePinocembrin
The invention relates to the medical field, discloses applications of racemes of pinocembrin, racemes of pinocembrin salt, racemes of pinocembrin precursors or racemes of pinocembrin hydrate in preparation of medicals for preventing and treating cerebral apoplexy, and further discloses the application of racemes of pinocembrin in prevention and treatment of acute ischemic stroke.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Intracranial hemorrhage transformation model after acute cerebral ischemia mechanical recanalization and microRNA screening method and application thereof
InactiveCN109006662AIncrease success rateImprove stabilityAnimal husbandryAcute hyperglycaemiaReperfusion injury
The invention provides an intracranial hemorrhage transformation model after acute cerebral ischemia mechanical recanalization and a microRNA screening method and application thereof. The intracranialhemorrhage transformation model after acute cerebral ischemia mechanical recanalization is established by using a hyperglycemia combined suture-occluded method MCA for occlusion for 5 hours and thenrecanalization for 19 hours. The intracranial hemorrhage transformation model has 33 microRNAs expressions with significant difference. A new method for the study of intracranial hemorrhage transformation after acute cerebral ischemia mechanical recanalization, and an innovative means for the diagnosis and treatment of reperfusion injury after endovascular interventional recanalization in acute ischemic stroke is provided.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Indexes and system for predicting prognosis of acute ischemic stroke patients undergoing vascular recanalization treatment
ActiveCN111513704AProof of relevanceDiagnostic signal processingMedical automated diagnosisCorrelation analysisCerebral arterial thrombosis
The invention discloses indexes and a system for predicting prognosis of an acute ischemic stroke patient undergoing vascular recanalization treatment. The indexes comprise PAC variability and parameters thereof. Correlation analysis proves that the PAC variability and the parameters thereof are related to prognosis of cerebral arterial thrombosis patients. According to the research results, the invention develops the system and a method for predicting prognosis of the acute ischemic stroke patient undergoing vascular recanalization treatment, and provides a new strategy for clinical prediction of prognosis of the patients.
Owner:BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Biomarkers for predicting risk of acute ischemic stroke and methods of use thereof
Biomarkers useful for the diagnosis and treatment of acute ischemic stroke are disclosed. Also provided is a quantitative assay method for accurately identifying transcript number in a biological sample.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Application of circular RNA circ-FoxO3 in preparation of products for preventing and treating cerebral arterial thrombosis
ActiveCN112156103AImprove permeabilityPromote apoptosisOrganic active ingredientsNervous disorderCerebral arterial thrombosisAcute ischemia
The invention belongs to the field of biotechnology and cerebral arterial thrombosis, and particularly relates to application of circular RNA circ-FoxO3 in preparation of products for preventing and treating cerebral arterial thrombosis. The circular RNA is highly conservative and has the same reverse shearing site in human-derived or mouse-derived species. The application proves that the circ-FoxO3 is highly expressed in cerebrovascular endothelial cells of a MCAO / R mouse and the cerebrovascular endothelial cell line subjected to OGD / R treatment; A certain effect of the circ-FoxO3 in the endothelial barrier treated by OGD / R is shown by knockdown or over-expression of the circFoxO3. The application of the circular RNA circ-FoxO3 provides a new thought for prevention of hemorrhagic transformation after acute ischemic stroke, and provides a new target for development of a neurovascular protective agent.
Owner:THE FIRST AFFILIATED HOSPITAL OF JINAN UNIV
Thrombus extraction scaffold
The invention discloses a thrombus extraction scaffold. Specifically, the thrombus extraction scaffold comprises a scaffold body and a push rod; the scaffold body is formed by cutting a metal tube, and the cut metal tube is in a shape of helical crossing of a plurality of strands of metal ribs; the metal ribs are gathered to form a first gathering point at the far end of the scaffold body, the near end of the scaffold body is in a diagonal shape, and the metal ribs are gathered to form a second gathering point at the near end of the scaffold body; developing wires are attached to any strand ofthe metal ribs, and the developing wires are attached to the metal ribs; a notch is formed in the second gathering point, the far end of the push rod is provided with an insert matched with the notch, the notch and the insert are assembled and fixed through embedding, and the scaffold body and the push rod are connected to form a whole. The thrombus extraction scaffold is used for mechanically extracting thrombi blocking intracranial vessels when acute ischemic stroke of a patient happens, so that the treatment purposes of revascularization and blood flow recovery are achieved.
Owner:ENEIDE MEDICAL TECH SHANGHAI CO LTD
Novel KCNQ potassium channel agonist and preparation method and application thereof
ActiveCN105017085ANot easy to oxidize and deteriorateNot easy to oxidize and change colorUrea derivatives preparationNervous disorderConvulsionEfficacy
The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutically acceptable salt thereof in the preparation of medicaments for treating nervous system diseases, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke or neurodegenerative diseases. Compared with Retigabine, the compound of the present invention has better brain tissue absorption. Moreover, the compound provided by the present invention not only has greatly improved efficacy, but also has far fewer neurological side effects than Retigabine, and therefore has a wider safe window.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Chinese medicinal preparation for treating acute ischemic stroke
InactiveCN104383038AGood treatment effectImprove securityAnthropod material medical ingredientsDispersion deliveryTreatment effectNeurological impairment
Owner:胡万华
SNP marker relevant with treatment of ischemic stroke through antiplatelet drug clopidogrel and application thereof
ActiveCN106701923AEasy to detectIncreased sensitivityMicrobiological testing/measurementDNA/RNA fragmentationGeneticsAntiplatelet drug
The invention discloses a SNP marker relevant with treatment of ischemic stroke through antiplatelet drug clopidogrel and application thereof, as well as a special amplification primer and a special extension primer for detecting the marker. The SNP marker is combination of rs6686001, rs2302429, rs2242480, rs4244285 and rs2046934. Sequences of each marker, the special amplification primer and the special extension primer are sequentially respectively as shown in SEQ ID No. 1-20. According to the SNP marker combination, clopidogrel-resistant and clopidogrel-effective ischemic stroke people can be distinguished well. The SNP marker, the amplification primer thereof and a relevant kit can be used for clinical medication guidance for adopting the antiplatelet drug clopidogrel to treat ischemic stroke patients, medicine resistance is prevented, and a treatment effect is enhanced.
Owner:SUN YAT SEN UNIV +1
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