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82 results about "Physiological actions" patented technology
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Physiological actions of opiates. Opiates (e.g., morphine, codeine, and thebaine) exert their main effects on the brain and spinal cord. Their principal action is to relieve or suppress pain. The drugs also alleviate anxiety; induce relaxation, drowsiness, and sedation; and may impart a state of euphoria or other enhanced mood.
Method and sysem for non-ablative acne treatment and prevention
InactiveUS20080294073A1Reduce acneReduce sebum productionUltrasonic/sonic/infrasonic diagnosticsUltrasound therapyNon ablativeApoptotic programmed cell death
A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
Owner:GUIDED THERAPY SYSTEMS LLC
Chinese medicinal herb antistaling agent for stem vegetables
ActiveCN101427705AExtended shelf lifeReduce the impactFruit and vegetables preservationPreservativeFilm-forming agent
The invention provides a preparation method and application technique of Chinese herbal medicine preservative for vegetables, especially a preserving method of stalk vegetables such as wormwood at normal-temperature condition, comprising a concrete composition of Chinese herbal medicine preservative and application method. The Chinese herbal medicine preservative comprises a Chinese herbal medicine extracting solution, a film-forming agent and a solvent. The growth of the microbe on the surface of the stalk vegetables such as wormwood is inhibited using the sterilization and antiseptic action of the Chinese herbal medicine extracting solution, at the same time a layer of film is formed on the surface of the vegetable using the film-forming agent and the vegetables respiration and other physiological action are reduced, therefore the shelf life can be prolonged and the storage period of stalk vegetables such as wormwood can be prolonged to above two times than the prior technique.
Owner:北京航天农业生物科技有限公司
Two-photon formaldehyde fluorescent probe and preparation and application thereof
ActiveCN105924394AStrong specificityReduce autofluorescence backgroundOrganic chemistryFluorescence/phosphorescenceFluorescenceCell membrane
The invention discloses a two-photon formaldehyde fluorescent probe and preparation and application thereof. The probe is a novel formaldehyde probe taking 1,8-naphthalimide as a two-photon fluorogen on the basis of an intramolecular charge transfer mechanism. Probe molecules have good light stability and a large Stoke's shift, the probe can well detect the formaldehyde concentration in a neutral buffer solution, and meanwhile compared with other aldehyde compounds, the probe has good specificity on formaldehyde. It is well proved through two-photon confocal fluorescence microscopic imaging experiments that the probe can permeate through a cell membrane to enter cells and can detect a change of the formaldehyde concentration in the cells, and an effective research tool for researching the physiological action of formaldehyde in the cells is provided.
Owner:ZHEJIANG UNIV OF TECH
Method of treating migraine headache without aura
InactiveUS7214711B2Function increaseUseful in treatmentBiocideNervous disorderNervous systemTreatment pain
The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neurophsyciatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and / or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed. The present invention also relates to methods and compositions for treating pain by administering ion-dependent cotransporter antagonists. Methods and compositions for enhancing cortical function, for example, in centers of cognition, learning and memory, by administering ion-dependent cotransporter agonists are disclosed.
Owner:NEUROTHERAPEUTICS PHARMA
Small peptide additive for porcine feed and preparation method thereof
InactiveCN102318779AEasy feedingPromote absorptionAnimal feeding stuffAccessory food factorsNutritional statusRapeseed
The invention provides a small peptide additive for porcine feed and a preparation method thereof; the small peptide additive for porcine feed is characterized in that the additive is prepared by mixing base materials, saccharomyces cerevisiae liquid, lactobacillus acidophilus liquid, bacillus subtilis liquid and water according to a weight ratio of 100:3-4:3-4:5-7:35-4, and performing solid fermentation; the base materials comprise 50-70 wt% of soybean meal, 4-5 wt% of rapeseed meal, 10-15 wt% of fish meal, 5-8 wt% of vinasse, 2-5 wt% of corn starch, 1-3 wt% of wheat bran, 1-3 wt% of molasses, 1-3 wt% of yellow mealworm, and 0.5-1 wt% of sodium carbonate. The small peptide additive for porcine feed of the invention can increase the synthesis speed of protein for pig body, promote food ingestion of pigs, increase appetite, improve immunity, promote the absorption of mineral elements by pig body, regulate various physiological actions of the body, reduce stress, and improve the nutritional status of pig body.
Owner:SHANGHAI CHUANGBO ECOLOGICAL ENG
Phellinus igniarius juice health-care food and preparation method thereof
InactiveCN105639627AImprove immunityEasy to operateFood ingredient functionsFruit juiceAdditive ingredient
The invention provides a phellinus igniarius juice health-care food and a preparation method thereof. The preparation method comprises the following steps of firstly, preparing a liquid fermentation medium; secondly, performing liquid fermentation on a phellinus igniarius strain; thirdly, collecting fermentation liquor obtained by fermenting phellinus igniarius liquid, and performing clarification or homogenization treatment on the fermentation liquor; fourthly, performing sterilizing, filling or spray drying treatment on the clarified or homogenized fermentation liquor. According to the phellinus igniarius juice health-care food and the preparation method thereof provided by the invention, juice is utilized to directly serve as a carbon source for fermenting phellinus igniarius, and nutritional ingredients and health-care ingredients obtained by fermenting the phellinus igniarius directly infiltrate into the juice to prepare the healthy food with the function of enhancing the physiological actions such as immunity and the like. The phellinus igniarius juice health-care food and the preparation method thereof have the advantages of simple technical operation, safety, reliability and suitability for industrialized large-scale production.
Owner:TIANJIN TIANLIN XINRAN BIOTECH CO LTD
Cyanin-based organic compound and application thereof
ActiveCN104119263AUnderstand the physiological roleReduce distractionsOrganic chemistryMethine/polymethine dyesBiological bodyUltraviolet absorption
The invention relates to a fluorescence probe, and particularly relates to a cyanin-based organic compound and an application thereof. A structural formula of the cyanin-based organic compound is as shown in the formula I in the specification. According to the compound serving as a cysteine fluorescent probe, the corresponding fluorescence intensity obviously changes under the existence of cysteine, the compound can be applied to cysteine detection, the interference of an external detection condition can be greatly reduced, and the detection accuracy is improved. According to the compound serving as the cysteine fluorescent probe, ultraviolet absorption obviously changes under the existence of cysteine, and the compound serving as the cysteine fluorescent probe can be simultaneously used for detection by using an ultraviolet spectrophotometer and naked eyes. The compound can be applied to detection of cysteine levels inside and outside a cell as the fluorescent probe, and the compound has important biomedical significance on intensive study of dynamics mechanism of the processes of cysteine generation, transportation and accumulation inside a living body, particularly study of physiological action of cysteine in mitochondria.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Functional edible oil containing lycoypene
The invention relates to functional edible oil containing lycoypene. According to the invention, plant edible oil contains lycoypene and vitamin E. The invention is characterized in that 100g of the plant edible oil contains 12-200mg of lycoypene and 2-20mg of vitamin E, the lycoypene and the plant edible oil form a uniform and clear mixture, and precipitation capacity of the lycoypene is not more than 5 percent after the functional edible oil stands still for 120-168 hours. The function edible oil does not contain chemical antioxidants and has natural oxidation resistance. On the basis of research on the property and function of lycoypene, a proper amount of lycoypene is added to plant edible oil and can be ingested by people through cooking, the physiological action of lycoypene can be fully played, and the functional edible oil has health-care and treatment effects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Building method of two-level fitting quantitative structure-activity relationship (QSAR) model for forecasting compound activity
InactiveCN102930113APredict biological activityTight fitBiological neural network modelsSpecial data processing applicationsEngineeringLinear model
The invention discloses a building method of a two-level fitting quantitative structure-activity relationship (QSAR) model for forecasting compound activity. The building method includes following procedures: 1 a plurality of compounds with the same frames are utilized as a training set, and the train set compounds are divided into substituent groups and are coincided; 2 a linear regression method is utilized to calculate local physiological action produced by each substituent group, and a preceding-stage fitting model is built; 3 according to the local physiological action which is obtained in calculating mode in the procedure 2, a neural network method is utilized to calculate the whole biological activity, and a backward-stage fitting model is built; and 4 the preceding-stage fitting model and the backward-stage fitting model are combined to form the front-and-back two-stage QSAR model. According to the building method, the linear regression method and the neural network method are combined to build the model, the neural network method has good fitting performance, and compared with a traditional linear model, the built model can accurately forecast the biological activity of the compounds.
Owner:SOUTH CHINA AGRI UNIV
Methods for treating a variety of diseases and conditions, and compounds useful therefor
In accordance with the present invention, there are provided novel compounds that have a variety of properties, i.e., antioxidant, anti-inflammatory, antiviral, antibacterial, and antifungal properties. Invention compounds, therefore, have the ability to impart a variety of beneficial physiological effects, e.g., to protect neurons and / or to promote neuroregeneration and / or to promote memory formation and / or to act as protein phosphatase or kinase inhibitors and / or to act as lipoxygenase inhibitors. Such compounds are useful for treatment of a variety of indications, including neurodegenerative diseases and conditions, diabetes, ischemia associated with heart disease, and memory deficit. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and / or adjuvants to facilitate delivery thereof across the blood / brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e.g., acute neural injuries, chronic injuries, promoting memory formation, and the like.
Owner:SALK INST FOR BIOLOGICAL STUDIES
Recombinant gland related virus expressing human kallikrein, its preparation method and application
InactiveCN1412303AFunction increaseHigh infection efficiencyViruses/bacteriophagesAntibody medical ingredientsDiseaseHuman body
The present invention provides a recombinant glandular related virus capable of expressing human kallikrein, its preparation method and application, and medicine composition containing said recombinant glandular related virus. Said recombinant glandular related virus can drive the human kallikrein gene to make long-period expression in human body, and possesses good physiological and pathologic physiological action for effectively reducing blood pressure, improving renal function and preventing apoplexy, and can be used for clinical curing the above-mentioned diseases.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
Preparation method and applications of enhanced type fluorescent probe for detecting hydrogen sulfide
InactiveCN104479669AGood optical stabilityImprove solubilityOrganic chemistryFluorescence/phosphorescencePotassium carbonateNile red
The invention provides an enhanced type fluorescent probe for detecting hydrogen sulfide. The fluorescent probe is an NRS fluorescent probe, the structural general formula of the NRS fluorescent probe is shown as (I), the preparation method comprises the following steps: adding nile red, 2,4-dinitrofluorobenzene and potassium carbonate into dimethylformamide, heating to 70-80DEG C, performing reflux reaction for 3 hours, extracting the reaction liquor by dichloromethane and collecting an organic phase, drying the organic phase with anhydrous magnesium sulfate, and purifying through silica column chromatography to obtain a target product. The probe has a mitochondrial location function, can perform real-time and on-site online detection to mitochondria, and can help us to further master the physiological function of the hydrogen sulfide and promote the understanding of physiological action of H2S, and provide a visible detection tool for research and development of novel cardiovascular drugs.
Owner:LIAONING UNIVERSITY
Neutralization-free furfural wastewater biochemical treatment process
InactiveCN101439914AReduce processing costsImprove decomposition abilityTreatment with aerobic and anaerobic processesMultistage water/sewage treatmentActivated sludgeSequencing batch reactor
The invention relates to biochemical treatment technology for unneutralized furfural wastewater. The furfural wastewater enters into an emergency reservoir first; partial furfural wastewater produced during production of furfural each day enters into a regulating reservoir, and the other part of the furfural wastewater enters into the emergency reservoir; the furfural wastewater in the emergency reservoir is extracted and pumped into the regulating reservoir by a temperature adjusting pump, and the temperature of the furfural wastewater in the regulating reservoir is adjusted to be between 35 and 40 DEG C; the furfural wastewater is lifted by a sewage pump into an anaerobic sequencing-batch reactor, and is fully mixed with anaerobe; a large part of organic pollutant is decomposed into methane and water under the physiological action of the anaerobe; when the pH of a solution in the anaerobic sequencing-batch reactor is raised to be between 7.0 and 7.2, operation of a circulating pump and a pulse feeder is stopped for entering into a precipitation stage; after precipitation, the water flows into an intermediate reservoir through a siphonic decanting drainer; and the wastewater in the intermediate reservoir is lifted by an intake pump of a sequencing-batch activated sludge process, enters into a reservoir of the sequencing-batch activated sludge process according to operation rules of the sequencing-batch activated sludge process, is purified, enters into a clean water reservoir, is subjected to strong oxidation treatment of ozone, and is released after reaching the standard.
Owner:张动科
Pharmaceutical composition capable of improving sleep as well as preparation and application thereof
InactiveCN107456531AGood analgesic effectInhibition of central excitabilityOrganic active ingredientsNervous disorderConvulsionPalpitations
The invention relates to a pharmaceutical composition capable of improving sleep as well as a preparation and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 5-50 parts of theanine, 5-20 parts of gamma-aminobutyric acid, 50-100 parts of spina date seeds and 50-100 parts of gastrodia elata. A pharmaceutical preparation comprises the previous pharmaceutical composition. The invention further provides application of the pharmaceutical composition in preparation of a medicine with an effect of improving the sleep. According to the pharmaceutical composition in the invention, the theanine has the effects of resisting depression, calming the mind, regulating changes of neurotransmitters in the brain, improving the learning ability and memory and resisting fatigue; the gamma-aminobutyric acid has physiological effects of calming, promoting hypnosis, resisting convulsion and reducing blood pressure; the spina date seeds have the effects of nourishing the liver, calming heart, soothing nerves, arresting sweating, and treating various symptoms such as dysphoria and egersis, palpitation, polydipsia, abnormal sweating and the like; and the gastrodia elata has the effects of calming, resisting convulsions and reducing the blood pressure. According to the synergistic effects of the previous components, the aim of improving the sleep is achieved.
Owner:JIANGSU DEHE BIOTECH
Chinese medicinal herb antistaling agent for stem vegetables
The invention provides a preparation method and application technique of Chinese herbal medicine preservative for vegetables, especially a preserving method of stalk vegetables such as wormwood at normal-temperature condition, comprising a concrete composition of Chinese herbal medicine preservative and application method. The Chinese herbal medicine preservative comprises a Chinese herbal medicine extracting solution, a film-forming agent and a solvent. The growth of the microbe on the surface of the stalk vegetables such as wormwood is inhibited using the sterilization and antiseptic action of the Chinese herbal medicine extracting solution, at the same time a layer of film is formed on the surface of the vegetable using the film-forming agent and the vegetables respiration and other physiological action are reduced, therefore the shelf life can be prolonged and the storage period of stalk vegetables such as wormwood can be prolonged to above two times than the prior technique.
Owner:北京航天农业生物科技有限公司
Method for producing and preparing selenium-enriched chicken feed through yeast fermentation
InactiveCN107960557AIncrease selenium contentPromote absorptionFood processingAnimal feeding stuffBiotechnologyHigh absorption
The invention discloses a method for producing and preparing a selenium-enriched chicken feed through yeast fermentation. The method comprises the following steps of performing inoculating with yeaston a culture solution with sodium selenite for domesticizing, screening out selenium-enriched yeast strains, using selenium-enriched peanut shells, stalks and selenium-enriched corn as main raw materials of a fermentation substrate, and performing fermentation production of the selenium-enriched feed. Through the physiological action of the strains, the process of converting inorganic selenium inthe raw materials of the feed into organic selenium is promoted, and absorption of selenium by chicken bodies is facilitated, so that the enrichment of the selenium in the chicken bodies is promoted,the immunity of animals is improved, and the economic benefits are increased; and besides, through aerobic-anaerobic fermentation treatment, the fermentation efficiency is improved, the palatability of the feed is improved, high absorption rate of a selenium yeast feed by the chicken bodies is guaranteed, and daily feed nutrients are supplemented and improved.
Owner:MAANSHAN WUGU POULTRY IND SPECIALIZED COOP
Composite anti-aging composition containing plant extract and application thereof
ActiveCN109303727APromote hydrationEnhanced barrier functionCosmetic preparationsToilet preparationsAdditive ingredientBarrier function
The invention discloses a composite anti-aging composition containing a plant extract and application thereof. An effective component of the anti-aging composition is formed by compounding hyalurate,polypeptide and an anti-aging plant extract. The anti-aging composition simultaneously contains the hyalurate, the polypeptide and the anti-aging plant extract in 3 types of molecular weights. The three parties can achieve the effect together under the skin physiological action of hydration, a barrier function, oxidation and inflammation and the like, have coordinated synergism, and are capable ofachieving the good anti-aging effect. In addition, the anti-aging composition is simple in component type, easy to prepare, and easy to be mixed in cosmetics with other components, and has the apparent advantage of being capable being easily added into various types of formulas.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD
Coffee partner containing octacosanol and manufacture method thereof
InactiveCN101204216AIncrease physical strengthRegulate metabolismHydroxy compound active ingredientsMetabolism disorderSucroseAdditive ingredient
The invention relates to a coffee mate which contains octacosanol and a preparation method thereof, belogning to the beverage field. The coffee mate which contains octacosanol can adopt the microcapsule form, the sucrose and the Beta-cyclodextrin are the materials of the wall, the octacosanol and the palm oil and other components are the core materials. The invention is characterized in that the invention does not contain trans fatty acid; the added natural active ingredient which is the octacosanol has the physiological actions of anti-fatigue, building up body strength and reducing blood cholesterol, etc. By drinking the coffee mate, the physical fitness of the tired person can be recovered quickly, and the speed of getting rid of fatigue is quick; the body metabolism can be adjusted and the physique can be improved by drinking the coffee mate chronically. The invention caters to the consumption demands of health and nutrition of modern consumers, and the invention also corresponds with the development direction of the prior beverage industry, and the market prospect is very bright.
Owner:TIANJIN UNIV OF SCI & TECH
Fusion protein containing glicetin-1 as well as preparation method and application
ActiveCN102585015AAdvantages of hypoglycemic effectProlonged plasma half-lifePeptide/protein ingredientsMetabolism disorderNucleotideGlucagon-like peptide-1
The invention discloses a fusion protein containing glicetin-1 (GLP-1) as well as a preparation method and application. The fusion protein has the amino acid sequence shown in SEQ ID NO.1. According to the invention, an amino acid with known sequence is mutated by a gene engineering method to obtain the nucleotide sequence encoding the fusion protein provided by the invention, then the nucleotide sequence is cloned to an expression carrier, and expression and purification are carried out to obtain the fusion protein. By adopting the fusion protein containing GLP-1, the GLP-1 has better stability and duration in physiological action; furthermore, pharmacodynamic result shows that the fusion protein has significant effect of reducing blood sugar; and in addition, by long-term injection of the fusion protein, the sugar tolerance is significantly improved, the insulin secretion is stimulated, pancreatic island beta cells are protected and the development of the diabetes course is delayed. Therefore, the GLP-1 fusion protein has extraordinary advantages and potential to be applied to clinical treatment.
Owner:JINAN UNIVERSITY
Spinous process and vertebral plate stabilizer
The invention relates to a spinous process and vertebral plate stabilizer, and belongs to the technical field of an elastomer for vertebral plate dynamic fixation. The spinous process and vertebral plate stabilizer includes a first fixing portion, a second fixing portion, and an elastic device; the first fixing portion is connected to the second fixing portion through the elastic device; a first fixing portion is of a clamp-shaped structure formed by two side wings a and a bottom plate; the second fixing portion is of a clamp-shaped structure formed by two side wings b and an arc bottom plate; and the elastic device consists of a first elastic structure, a second elastic structure and a third elastic structure. The spinous process and vertebral plate stabilizer fully considers the demands of physiological actions of a human body, can achieve maximum matching with the activity in all the directions, is reasonable in structure, is strong in vertical support force, is small in size, is reliable in fixation, and is high in elasticity attenuation resistance ability and can be used for the human body in a long term; rotation centers of a coronal view and a sagittal view of a prosthesis are close to rotation centers of a coronal view and a sagittal view of a spine of the human body after the stabilizer is implanted; and the spinous process and vertebral plate stabilizer is conductive to postoperative recovery of a patient, is easy to operate, and can lower the difficulty and risks of an operation.
Owner:李照文
Making method of blood replenishing and qi regulating health care nutrient drinks
The invention discloses a making method of blood replenishing and qi regulating health care nutrient drinks, belonging to the technical field of special purpose drinks. The making method comprises the following steps of: 1, carrying out superfine grinding, carrying out ultrasonic water leaching of effective components, ultra-filtering to respectively obtaining extracting solutions of dangshen, fleece-flower root and Chinese angelica; 2, mixing the following components in parts by weight: 1.9-2.1 parts of dangshen extracting solution, 1.9-2.1 parts of fleece-flower root, 0.9-1.1 parts of Chinese angelica, 0.038-0.040 part of vitamin C, 0.011-0.013 part of iron lactate and 0.009-0.011 part of citric acid; and 3, adding brown sugar and water to be blended to obtain a blending solution, ultra-filtering the blending solution by using an ultra-filtering device, carrying out sterile cold filling by using a sterile cold filing device, and finally, carrying out ultra-high temperature instant sterilization by using an ultra-high temperature instant sterilization device. The blood replenishing and qi regulating health care nutrient drinks have important physiological functions of replenishing blood, regulating qi, promoting secretion of saliva or body fluid, and enhancing organism immunity, are especially suitable for puerperae suffering from weakness, qi deficiency and ischemia, and also has physiological actions of resisting oxidization, eliminating toxicant and nourishing skin, delaying ageing and the like.
Owner:YUNNAN ZHIWEIYUAN FOOD
Method for preparing microbial ecological agent for treating infertility
InactiveCN106974941AAids in treatmentImprove the chances of conceptionBacteriaMicroorganism based processesMicrobial agentTherapeutic effect
The invention studies the physiological action between vagina microorganisms and sperm cells with experimental means, and finds that certain vagina microorganisms can be specifically combined with sperms, so as to make sperms swim slower or even stop moving, or cause change in protein generation level of sperms to further affect the ability of sperms to be combined with eggs. Based on the findings, the invention determines a technical route for improving sperm motility by interfering with vaginal flora; microorganisms which can be well combined with sperms and do not affect basic physiological characters of sperms are selected out, adhesion of microorganisms harmful to sperms is prevented by means of the occupying function of the selected microorganisms, and therefore sperm motility can be improved, so as to relieve or treat infertility. Furthermore, probiotics microorganisms in a microbial agent are helpful for treatment of various diseases caused by vaginal flora dysbacteriosis, the treatment effect is remarkable, relapse probability is low, and popularization prospects are broad.
Owner:NANCHANG UNIV
Composition comprising multiple vitamins and hyalurate and application of composition
ActiveCN109330911ASimple ingredientsProvide comprehensivelyCosmetic preparationsToilet preparationsBULK ACTIVE INGREDIENTBarrier function
The invention discloses a composition comprising multiple vitamins and hyalurate and application of the composition, and the composition comprises the effective ingredients of the compound hyalurate,a small molecule peptide and the vitamins. The composition comprises the hyalurate, the ingredient of the small molecule peptide and the vitamins having three molecular weights at the same time, the hyalurate, the small molecule peptide and the vitamins work together under the physiological actions of the skin like hydration, barrier function, oxidation and inflammation, have a synergistic interaction, and achieves an excellent anti-aging effect. In addition, the composition is simple in ingredients, and relatively and comprehensively provides the anti-aging effect for the skin, the active ingredients have a synergistic interaction, and the safety is high.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD
Targeting vector for pig GHR gene knock-out and applications thereof
The invention belongs to the technical field of biology, and specifically discloses a targeting vector for pig GHR gene knock-out and applications thereof. The targeting vector is a sgRNA expression vector based on a CRISPR / Cas system; wherein the target sequences of sgRNA are arranged on the 10th exon and 3'UTR of a pig GHR gene. The provided targeting vector is applied to targeting knock-out ofpig GHR gene, and the knock-out efficiency can reach 12.7%. After the GHR gene is successfully knocked out, somatic cells can be used to establish a GHR gene knock-out pig model by a somatic cell nuclear transplanting technology, and materials are provided for the research of physiological action and molecular mechanism of GHR gene.
Owner:CHINA AGRI UNIV
Antihypelipidemic compound formulation
ActiveCN101406642AEliminate symptomsLower blood sugarMetabolism disorderPlant ingredientsAcute toxicity testingSide effect
The invention relates to a compound preparation for reducing blood sugar and belongs to the technical field of oral preparation. The product is characterized in that the compound preparation is prepared from the following traditional Chinese medicine materials in weight portion: 5 to 25 portions of polygonatum, 5 to 25 portions of herba lophatheri and 3 to 12 portions of balsam pear. Oral liquid is the preferred preparation form; and the compound preparation can also be prepared into different preparation forms. The product has a refined formula, can effectively reduce blood sugar of diabetic patients without causing hypoglycemia reaction, has prevention function, and is mainly used for diabetic prevention and treatment. A safety test, a pharmacodynamic test, an acute toxicity test and a clinical test prove that the product can improve the activity of insulin and reduce the production of mutant insulin so that the product realizes physiological action with higher efficiency, promotes the ingestion and utilization of glucose by tissues and cells, and balances the energy metabolism of organism, thereby removing the symptoms of the diabetic patients. The product has remarkable effect, stability, safety, no toxicity, no side effect and can be taken for a long time.
Owner:赛灵药业科技集团股份有限公司
Organic compound based on gallocyanine and application thereof
ActiveCN107722057AGroup 5/15 element organic compoundsFluorescence/phosphorescenceBiological bodyFluorescence
The invention relates to a fluorescence probe, in particular to an organic compound based on gallocyanine and application thereof. The structural formula of the organic compound based on the gallocyanine is shown in a first formula, and the compound is used for carrying out linkage detection on a mitochondrial outer membrane. The compound can be taken as the fluorescence probe for detecting MAO-Blevels in and out of cells so as to have an important biomedicine meaning on deeply researching the kinetic mechanisms of the way of MAO-B for catalyzing monoamine substances in a living body, and theproduction and accumulation process of catalysate and especially have an important biomedicine meaning on the physiological action of MAO-B in the living body and the influence of the catalysate to the living body. The formula is shown in the specification.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Topical agent for muscle treatment
A topical liposomal base delivery agent for physiologically enhancing muscle efficiency and relaxation, which combines the physiological effects of guaifenesin, magnesium, and methylsulfonylmethane. The resulting physiological reaction reduces muscle and joint soreness in the host. The present invention is an improvement over existing methods that deliver magnesium to muscle tissue.
Owner:HOLGATE ERIC
Treatment of sepsis and inflammation with alpha2A Adrenergic antagonists
InactiveUS20090202518A1Prevent reduce physiologic effectReducing and preventing effectBiocideOrganic active ingredientsAdrenergic antagonistAdrenergic receptor antagonists
Provided are methods for treating a mammal undergoing sepsis, or at risk for sepsis. Also provided are methods of preventing or treating a physiological effect of sepsis in a mammal. Additionally provided are methods of inhibiting an inflammatory response in a mammal. Further provided is the use of an α2A-adrenergic antagonist for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of an α2A-adrenergic antagonist for the treatment of a mammal having sepsis or at risk for sepsis.
Owner:THE FEINSTEIN INST FOR MEDICAL RES
Increasing cancer patient survival time by administration of dithio-containing compounds
ActiveUS9023805B2High activityHigh expressionOrganic active ingredientsHeavy metal active ingredientsDiseasePatient survival
Owner:LANTERN PHARMA INC
Chitosan gelatin having physiological response properties and application of chitosan gelatin to prevention adhesion in uterine cavity
InactiveCN110755695APhysiologically responsiveWith hemostasisSurgeryPharmaceutical delivery mechanismUterus operationsSterile water
The invention discloses chitosan gelatin having physiological response properties and an application of the chitosan gelatin to prevention adhesion in uterine cavity, and belongs to the technical field of pharmaceutics. The chitosan gelatin is prepared through the steps of adding active components having functions of stopping bleeding, resisting bacteria, promoting healing and the like to a non-chemical crosslinking thermo-sensitive bacteria-free water gelatin substrate, wherein under the room-temperature condition, the gelatin being favorable in flowing properties and being in the state of sol is convenient for medication in the uterine cavity, at the physiology temperature of wombs, the gelatin rapidly gelate and is solidified, physical isolation on wound parts after an intrauterine operation is completed, adhesion is avoided, besides, the functions of a biologicalactivity material are exerted, and quick healing of wound parts is promoted. After the wombs are restored, under the physiological action of proliferation and secretion, corrosion and erosion of the gelatin are completed, the gelatin is discharged outside the bodies along with secretion, and human intervention is not needed. The gelatin has the advantages of being simple to apply, capable of predicting effects, free from secondary intervene and the like, and can be used for preventing adhesion after intrauterine operations.
Owner:XI AN JIAOTONG UNIV +1
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