151 results about "Penicillium citrinum" patented technology

The invention relates to novel anti-tumor application of an alkaloid compound penicillium enol B1 from penicillium citrinum. The penicillium citrinum IBPT-5 is collected in the China Center for Type Culture Collection (CCTCC), which is located in Wuhan University and has the collection number of CCTCC NO:M2013713, on December 25, 2013. The compound has good anti-tumor activity to various tumor cells, and can be used for preparing cell proliferation inhibition medicines or anti-tumor medicines for anti-tumor study, wherein tumor cells comprise human colon cancer cells SW620, human hepatoma cells Huh7, human gastric carcinoma cells SGC-7901, human gastric carcinoma cells BGC-823, human colon cancer cells SW480, human esophageal cancer cells EC9706, human highly metastatic lung carcinoma cells 95-D, human hepatoma cells PLC, human gastric carcinoma cells HGC-27 and human lymphoma cells RAJI.

The invention relates to a citrinin compound penicitrinol M derived from Penicillium citrinum, a preparation method and application of the citrinin compound penicitrinol M. The compound has the effects of inhibiting tumor cell proliferation and has antineoplastic activity. The structural formula of the citrinin compound is shown in the formula (refer to the Specification). Through performing fermental cultivation on Penicillium citrinum ((i)Penicillium citrinum ( / i)) IBPT-5 to obtain a yeast and conducting separation and purification on the yeast, the compound is obtained. The experiment confirms that the compound has a better antineoplastic activity to human cervical carcinoma cell line hela, so that the citrinin compound penicitrinol M can be used for preparing cell proliferation suppressing drugs or antineoplastic drugs and used in antineoplastic researches.

The invention relates to a method for preparing an alkaloidal compound penicillium enol D2 derived from Penicillium citrinum and an application of penicillium enol D2. The compound has an effect of inhibiting proliferation of tumor cells and has antitumor activity. The structural formula is as shown in the specification. The compound is prepared by the steps: performing fermentation cultivation on Penicillium citrinum IBPT-5, and separating and purifying the compound from the fermented product. The experiment proves that the compound has high antitumor activity on the human lung carcinoma cell line A549. The compound can serve as a medicine for inhibiting cell proliferation or an antitumor drug to be used for antitumor research.

The invention relates to Penicillium citrinum CR-2CGMCC 3024 and an application thereof. The bacterium is Penicillium fungus, which has short cultivating period and high propagation speed. An abundant of uniform cellulose degradation enzymes can be cultivated at short time for generating fungus culture solution. The invention also provides a method for generating endoglucanase and exoglucanase by fermenting the bacterial strain in the liquid enzyme culture medium, which can produce endoglucanase and exoglucanase with higher vigor at short time, with simple and stable fermenting technique, low cost and high yield.

The invention discloses a method for preparing gamma-linolenic acid-rich grease through sea squirt-associated Penicillium citrinum Asc2-4 fermentation. The method comprises inoculating a fermentation medium with sea squirt-associated Penicillium citrinum Asc2-4, carrying out fermentation under the oxygen condition to obtain Penicillium citrinum mycelia, and extracting gamma-linolenic acid-rich grease from the Penicillium citrinum mycelia. The sea squirt-associated Penicillium citrinum Asc2-4 is preserved in the Guangdong microbiology culture center (GDMCC) On July 16, 2016 and has a preservation number of GDMCC NO: 60059. The method utilizes an easily available medium, has stable fermentation conditions and has simple processes and a high yield. The produced grease has high unsaturated fatty acid oil content and especially has high gamma-linolenic acid content. The gamma-linolenic acid can be used for production of foods, medicines and cosmetics, has a wide application range and has a good promotion and application prospect.

The invention relates to antifungal application of an essential oil composition to mildew fungi.The essential oil composition is a composition obtained after reforming and compounding natural plant essential oil. The essential oil composition mainly comprises limonene, 1,8-cineole, p-cymene, terpilenol and the like. Verticillium fusarium, aspergillus flavus, penicillium citrinum, bacillus subtilis, saccharomycetes and lactobacillus paracasei in the mildew fungi are selected, an antifungal activity test on the essential oil composition is conducted, and it is shown through the result that the essential oil composition has a good antifungal effect on the six kinds of fungi within a certain concentration range.When the essential oil compositon shows the obvious inhibition effect on the six kinds of fungi, the concentration of the essential oil composition ranges from 0.075 microliter per milliliter to 0.240 microliter per milliliter, and the concentration of propionic acid ranges from 0.045 microliter per milliliter to 0.263 microliter per milliliter. The effective concentration range of the essential oil composition is in the propionic acid range, and good application potential is achieved for antifungal operation of the mildew fungi.