The invention discloses mesoporous ZSM-5 zeolite, a mesoporous ZSM-5 zeolite-loaded metal sulfide catalyst and an application. The synthesizing method of the mesoporous ZSM-5 zeolite comprises the following steps: (1) after uniformly mixing diallylamine and concentrated hydrochloric acid, adding dimethyl diallyl ammonium chloride, uniformly stirring and reacting for 1-6 hours at 60-120 DEG C, and cooling to obtain a template agent DMMC (Dimethylol Methyl Carbamate); (2) preparing acidified aluminum sulfate liquor by aluminum sulfate, concentrated sulfuric acid and water; (3) adding water into water glass, uniformly stirring, adding NaOH, adding the template agent DMMC after cooling to room temperature, continuously stirring for 2-5 hours, then adding the acidified aluminum sulfate liquor under stirring, and stirring for 2-8 hours to obtain a gel in a final state; (4) crystallizing the gel in the final state obtained in the step (3), filtering, drying and calcining to obtain the mesoporous ZSM-5 zeolite. The mesoporous ZSM-5 zeolite-loaded metal sulfide catalyst prepared by taking the mesoporous ZSM-5 zeolite as a carrier is applied to hydrodesulfurization of 4, 6-dimethyl dibenzothiophene and hydrocracking reaction of n-decane, thereby greatly improving the raw material conversion ratio.