The invention discloses a preparation method of
neohesperidin dihydrochalcone. The preparation method comprises 1, adding
neohesperidin and an alkaline solution into a reactor, carrying out stirring
dissolution, adding a
palladium-carbon catalyst into the reactor, enclosing the reactor, replacing air in the reactor with
nitrogen gas, feeding
hydrogen into the reactor at the normal temperature to replace
nitrogen gas, carrying out a stirring reaction process under normal pressure, after the reaction is finished, replacing the
hydrogen gas in the reactor with
nitrogen gas, stopping the reaction and pumping out the reaction solution, and 2, adjusting pH of the reaction solution to 5-6, carrying out
crystallization at the normal temperature, carrying out
filtration to obtain crystals A, adsorbing the filtrate through a
macroporous resin, then carrying out
elution through
purified water to remove the salt in the filtrate, carrying out
elution through
ethanol, collecting the eluate, carrying out condensation and
crystallization, carrying out
filtration to obtain crystals B, merging the crystals A and B, and carrying out
freeze drying to obtain
neohesperidin dihydrochalcone. The preparation method realizes synthesis of
neohesperidin dihydrochalcone at the normal temperature under normal pressure through one kettle way, has simple processes and realizes a low production cost and high product
neohesperidin dihydrochalcone purity.