37 results about "Trilobatin" patented technology

The invention discloses an active extract which is extracted from fagaceae and other plants by using 5 to 95% alcohol aqueous solution serving as a solvent, wherein the content of the trilobatin in the active extract is between 30 and 99.9%. The invention also discloses a preparation method for the active extract and application thereof in preparing a medicament for treating diabetes mellitus, diabetes nephropathy and hepatic edema.

The invention discloses a functional sweetener and an extraction method thereof. The functional sweetener should contain a trilobatin component and is extracted from a malus plant. The extraction method comprises the following six main steps: digestion; extraction; preliminary separation; fine separation; concentration; and drying and crystallization. The eventually extracted functional sweetener is great in output and controllable in cost.

The invention discloses a method for preparing a mixed hypoglycemic preparation of phloridzin. The auxiliary materials are made into tablets or capsules; the mass ratio of described phloridzin, trilobatin, xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate is 0.1:0.15‑0.2:1‑2: 0.2‑0.4:2‑3:0.2‑0.5. In the present invention, phloridzin and trilobulin are mixed in an optimal ratio, and combined with a microcapsule process to prepare an oral tablet or capsule administration preparation, so as to exert the protective effect of trilobin on phlorizin and make phlorizin pass through Intestinal absorption, inhibiting SGLT increases the excretion of glucose from the urine, and thus uses this new target and mechanism to treat type II diabetes.

The present disclosure provides a first sweetening composition comprising a) a natural sweet-tasting carbohydrate, b) a stevia compound, c) rubusoside, a rubusoside derivative, neohesperidin, thaumatine, phloretin, trilobatin, monatin, hesperetin, an enzyme-treated steviol glycoside or any combination thereof, and d) tannin, wherein component d) is present in an amount in the range from 1 mg / l to 400 mg / l, or wherein, based on the total weight of components b), c) and d), component b) is present in an amount in the range from 45 to 75 wt-%, component c) in an amount in the range from 2 to 40 wt-%, and component d) in an amount in the range from 2 to 40 wt-%. Furthermore, the present disclosure provides a second sweetening composition comprising a) a natural sweet-tasting carbohydrate, b) a stevia compound, c) rubusoside or a rubusoside derivative, d) tannin and e) oak extract or pomegranate extract. And, the present disclosure provides a third sweetening composition comprising a) acesulfam or aspartame, b) sucralose, a stevia compound, saccharin or cyclamate, c) neohesperidin, thaumatine, rubusoside, a rubusoside derivative, phloretin, trilobatin, monatin and / or hesperetin, and d) tannin in an amount in the range from 1 mg / l to 400 mg / l or wherein, based on the total weight of components a), b), c) and d), the component a) is present in an amount in the range from 10 to 50 wt-%, component b) in an amount in the range from 15 to 65 wt-%, component c) in an amount in the range from 0.1 to 4 wt-%, and component d) in an amount in the range from 5 to 50 wt-%. The present disclosure also provides a fourth sweetening composition comprising a) 0.1 to 50 g / l of a natural sweet-tasting carbohydrate, b) 40 to 120 g / l of a natural sweet-tasting carbohydrate different from a), and c) 30 to 300 mg / l of rubusoside or a rubusoside derivative. Moreover, the present disclosure is about the use of said sweetening compositions for sweetening and preparing beverages as well as for preparing syrups as precursors and for the preparation of such beverages. The disclosure is also about a beverage comprising said sweetening compositions as well as about a process for preparing such beverage.

The invention provides a method for isolating a large amount of natural sweetener trilobatin, by adding ethanol with a volume fraction of 30-90% to the pulverized trilobatin raw material at a solid-to-liquid mass ratio of 1:10-50, and heating to reflux Separating, filtering the separating liquid, separating the filter residue and filtrate, concentrating the filtrate under reduced pressure until it has no alcohol smell, and obtaining the isolate; dissolving the isolate in water, and extracting with ethyl acetate, and concentrating the extract under reduced pressure to obtain ethyl acetate extract; The ethyl acetate extract was separated by high-speed countercurrent chromatography to obtain a natural sweetener. The separation method of the invention is simple and quick, the separation period is short, the monomer preparation amount is large, and the monomer has various pharmacological activities.