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Application of trilobatin to preparation of anti-HIV virus infection medicines

A virus infection, trelobatin pharmaceutical technology, applied in the field of medicine, to achieve the effect of wide source, long application history, high use value and safety

Inactive Publication Date: 2018-08-10
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies have shown that trelobatin has anti-HIV infection activity

Method used

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  • Application of trilobatin to preparation of anti-HIV virus infection medicines
  • Application of trilobatin to preparation of anti-HIV virus infection medicines
  • Application of trilobatin to preparation of anti-HIV virus infection medicines

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Experimental program
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Embodiment Construction

[0025] The present invention will be further described below in conjunction with experiments, but the protection scope of the present invention is not limited thereto.

[0026] Experiment 1: In vitro cloned virus infection model to detect the inhibitory effect of trilobatin on HIV cloned virus

[0027] experimental method:

[0028] 1) Gradual dilution of trilobatin, with HIV-1 SF162 , HIV-1 NL4-3 and HIV-1 81A and NL4-3 Equal volumes of the virus solution were mixed and co-incubated for 30 minutes, then added to the pre-inoculated TZM-b1 cell culture plate, and the virus control well and the cell blank control well were set;

[0029] 2) 48 hours after virus infection, the expression of luciferase in TZM-b1 cells was detected with a luciferase detection kit.

[0030] Experimental results such as figure 1 As shown, trilobatin can dose-dependently inhibit the activity of three HIV infectious clones, against HIV-1 SF162 , HIV-1 NL4-3 and HIV-1 81A and NL4-3 virus IC 50T...

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Abstract

The invention discloses application of trilobatin to preparation of anti-HIV virus infection medicines. According to researches, the trilobatin has broad-spectrum anti-HIV-1 activity and low cytotoxicity, and a possible mechanism includes that the trilobatin is capable of specifically targeting at a gp41 N-terminal repeat sequence area to further inhibit HIV entering. The trilobatin is expected tobe developed into excellent anti-HIV small molecule entering inhabitants.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of trilobatin in the preparation of anti-HIV virus infection drugs. Background technique [0002] AIDS (Acquired Immunodeficiency Syndrome, AIDS), also known as Acquired Immunodeficiency Syndrome, is a serious single-cause disease caused by Human Immunodeficiency Virus (Human Immunodeficiency Virus, HIV) infection. As of 2016, about 36.7 million people were infected with HIV worldwide, and 1 million people died of AIDS and related diseases. AIDS mainly includes the following three transmission routes: blood transmission, sexual transmission and vertical transmission from mother to child. Among them, sexual transmission between homosexuals and heterosexuals has become the most important way of AIDS transmission, with a proportion of 80%, and even as high as 90% in some African countries. At present, AIDS has become the largest infectious disease in human beings, seriously...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P31/18
CPCA61K31/7034
Inventor 李琳殷淑文赖芳圆梁太珍刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
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