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Application of trilobatin in preparing medicine for treating alzheimer disease

A technology for Alzheimer's disease and trilobatin, which is applied in the field of pharmacy to achieve the effect of easy access, wide source and good therapeutic effect

Inactive Publication Date: 2018-08-17
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no report of anti-AD

Method used

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  • Application of trilobatin in preparing medicine for treating alzheimer disease
  • Application of trilobatin in preparing medicine for treating alzheimer disease
  • Application of trilobatin in preparing medicine for treating alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of application of trilobatin in the preparation of medicine for treating Alzheimer's disease, take trilobatin 5g, medicinal starch 75g, microcrystalline cellulose 20g, medicinal starch is first dried, crosses 120 mesh sieves, and three Leaf glycosides and microcrystalline cellulose are mixed, passed through a 120-mesh sieve twice, and filled into hard capsules to make 1000 capsules of the present invention; each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0030] A kind of application of trilobatin in the preparation of medicine for treating Alzheimer's disease, get trilobatin 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, hard Magnesium stearate 1g; fully mix trelobatin with hypromellose, sodium starch glycolate, microcrystalline cellulose, lactose, starch, magnesium stearate and put it into a high-speed blender, spray with appropriate amount of water, Controlled at 3-4%, then compressed into tablets, made into 1000 tablets, coated with film.

Embodiment 3

[0032] An application of trilobatin in the preparation of medicines for treating Alzheimer's disease. Take 5g of trilobatin, add 400ml polyethylene glycol 200 to dissolve, then add appropriate amount of distilled water to dilute, then add appropriate amount of sucrose and adjust the volume to 1000ml , stir well, filter, fill into 10ml or 20ml each, and sterilize the package.

[0033] The invention adopts the Alzheimer's disease rat model induced by Aβ25-35 to study the therapeutic effect of trilobatin on the Alzheimer's disease. After the rat model of Alzheimer's disease was established by bilateral hippocampal injection of Aβ25-35, trilobatin (10 mg / kg) was given for 15 days. It was found that trelobatin has therapeutic effect on Alzheimer's disease, and can significantly reduce the release of pro-inflammatory factors (TNF-α and IL-1β) and the expression of TLR4, MyD88, and NF-κB.

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Abstract

The invention relates to application of trilobatin in preparing a medicine for treating an alzheimer disease. The medicine is prepared through the steps of adopting 5g of trilobatin, 75g of medicinalstarch and 20g of microcrystalline cellulose; firstly drying the medicinal starch, screening through a 120-mesh sieve, then mixing the trilobatin and the microcrystalline cellulose, screening throughthe 120-mesh sieve for two times, filling in a hard capsule, and obtaining 1000 pcs of capsules, wherein each hard capsule contains 0.5mg of main medicine component. According to the application of the trilobatin in preparing the medicine for treating the alzheimer disease provided by the invention, the trilobatin is adopted to prepare the re-perfused medicine for treating the alzheimer disease, and through animal experimental verification, the prepared medicine composition can be used for treating the alzheimer disease. The materials are wide in source, easy to get, simple and practical to prepare the medicine, and good in treatment effect.

Description

technical field [0001] The invention relates to the application of trelobatin in the preparation of medicines for treating Alzheimer's disease, belonging to the technical field of pharmacy. Background technique [0002] Alzheimer's disease (Alzheimer disease, AD) is one of the most common types of dementia, accounting for more than 60% of the incidence of dementia. The typical pathological features of AD are the formation of senile plaques (SP) caused by the deposition of extracellular β-amyloid (Aβ) and the formation of neurofibrillary tangles caused by hyperphosphorylation of tau protein , NFTs) and neuron loss accompanied by obvious synaptic loss, etc. These pathological changes lead to memory loss, mental disorders and movement disorders in patients, which seriously affect the daily life of patients and bring heavy burdens to families and society. [0003] Alzheimer's disease is a heterogeneous disease with multiple causes. Its etiology and pathogenesis have not been fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/48A61K9/28A61K9/20A61K9/08A61P25/28
CPCA61K31/7034A61K9/08A61K9/2059A61K9/28A61K9/4866A61K47/26A61P25/28
Inventor 龚其海高健美韦余
Owner ZUNYI MEDICAL UNIVERSITY
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