A kind of method for preparing phloridzin mixed hypoglycemic preparation

A phloridzin and hypoglycemic technology, applied in the directions of drug combination, pill delivery, pharmaceutical formulation, etc., can solve problems such as loss of activity, and achieve the effects of prolonging shelf life, preventing inactivation and good stability

Active Publication Date: 2022-08-05
GUANGXI FORESTRY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when phloridzin is administered orally, it will be hydrolyzed into phloretin and glucose by β-glucosidase in the intestine, thereby losing its activity

Method used

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  • A kind of method for preparing phloridzin mixed hypoglycemic preparation
  • A kind of method for preparing phloridzin mixed hypoglycemic preparation
  • A kind of method for preparing phloridzin mixed hypoglycemic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing a mixed hypoglycemic preparation of phloridzin, comprising the steps of: microencapsulating phloridzin and trilobulin, and then adding xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate as auxiliary materials Made into tablets or capsules. The mass ratio of phloridzin, trilobatin, xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate is 0.1:0.15:1.5:0.3:2.7:0.03.

[0035] The microencapsulation treatment comprises the following steps:

[0036] (1) Pulverize phloridzin and trilobitin into fine powder, pass through a 100-mesh sieve, add 5 times of the fine powder with warm water at 60°C, and add 1% mannooligosaccharide and 1.5% sucrose fatty acid by mass of the fine powder. Glycerides were sonicated for 20 min to obtain a core material system;

[0037] (2) Mix the soybean lecithin, linseed gum and chitosan with a mass ratio of 6:2:1 evenly, then add the mixture to the core material system, stir evenly, and ...

Embodiment 2

[0040] A method for preparing a mixed hypoglycemic preparation of phloridzin, comprising the steps of: microencapsulating phloridzin and trilobulin, and then adding xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate as auxiliary materials Made into tablets or capsules. The mass ratio of phloridzin, trilobatin, xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate is 0.1:0.17:2:0.4:2.3:0.05.

[0041] The microencapsulation treatment comprises the following steps:

[0042](1) Pulverize phloridzin and trilobitin into fine powder, pass through a 100-mesh sieve, add 6 times of fine powder with warm water at 70°C, and add 0.9% mannooligosaccharide and 0.9% sucrose fatty acid by mass of fine powder Glycerides were sonicated for 30 min to obtain a core material system;

[0043] (2) Mix the soybean lecithin, linseed gum and chitosan with a mass ratio of 8:2:2 evenly, then add the mixture to the core material system, stir evenly, and the mass r...

Embodiment 3

[0046] A method for preparing a mixed hypoglycemic preparation of phloridzin, comprising the steps of: microencapsulating phloridzin and trilobulin, and then adding xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate as auxiliary materials Made into tablets or capsules. The mass ratio of phloridzin, trilobatin, xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate is 0.1:0.20:1.5:0.5:2.5:0.04.

[0047] The microencapsulation treatment comprises the following steps:

[0048] (1) Pulverize phloridzin and trilobitin into fine powder, pass through a 100-mesh sieve, add 7 times of the fine powder with warm water at 70°C, and add 0.5% mannooligosaccharide and 1.0% sucrose fatty acid by mass of the fine powder. Glycerides were sonicated for 20 min to obtain a core material system;

[0049] (2) Mix soybean lecithin, flaxseed gum and chitosan with a mass ratio of 6:3:1, then add the mixture to the core material system, stir evenly, and the mass...

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Abstract

The invention discloses a method for preparing a mixed hypoglycemic preparation of phloridzin. The auxiliary materials are made into tablets or capsules; the mass ratio of described phloridzin, trilobatin, xylitol, microcrystalline cellulose, maltodextrin and magnesium stearate is 0.1:0.15‑0.2:1‑2: 0.2‑0.4:2‑3:0.2‑0.5. In the present invention, phloridzin and trilobulin are mixed in an optimal ratio, and combined with a microcapsule process to prepare an oral tablet or capsule administration preparation, so as to exert the protective effect of trilobin on phlorizin and make phlorizin pass through Intestinal absorption, inhibiting SGLT increases the excretion of glucose from the urine, and thus uses this new target and mechanism to treat type II diabetes.

Description

technical field [0001] The invention relates to the technical field of medicines and health products, in particular to a phloridzin mixed hypoglycemic preparation and a preparation method thereof. Background technique [0002] SGLTs (sodium-dependent glucose cotransporters) are a family of glucose transporters found in the intestinal mucosa (enterocytes) of the small intestine and in the proximal tubules of the nephron. SGLT aids in renal glucose reabsorption. In the kidney, 100% of the filtered glucose in the glomerulus must be reabsorbed along the nephron. In situations where plasma glucose concentrations are too high (hyperglycemia), glucose is excreted in the urine because SGLT is saturated with filtered monosaccharides. Inhibition of SGLT2 results in lower blood glucose levels. Therefore, SGLT2 inhibitors can be used to treat type II diabetes. [0003] Phloridzin, English name: phloridzin dihydrate, alias 1-(2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/48A61K47/38A61K47/10A61K47/36A61K47/12A61K9/50A61K47/24A61K47/14A61K47/32A61K31/7034A61P3/10
CPCA61K9/2054A61K9/2018A61K9/2059A61K9/2013A61K9/4858A61K9/4866A61K9/5015A61K9/5036A61K9/5089A61K31/7034A61K47/32A61P3/10A61K2300/00
Inventor 杨漓周丽珠谷瑶李桂珍
Owner GUANGXI FORESTRY RES INST
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