The invention discloses a
metoprolol tartrate sustained-release tablet and a preparation method thereof. The
metoprolol tartrate sustained-release tablet is prepared from the following components in percentage by weight: 39-57 percent of
metoprolol tartrate, 17-31 percent of retardant, 4-15 percent of
adhesive, 9-24 percent of filler, 1-3 percent of
lubricant, 1-2 percent of flow aid and 1-4 percent of
coating premix. According to the preparation method, a method of twice separately granulating
metoprolol tartrate and partial medicinal auxiliaries is adopted, and a
fluidized bed is adopted for granulating. Compared with a traditional wet
granulation method, the preparation method has the advantages that raw and auxiliary materials are separately granulated by the
fluidized bed according to different properties, and play roles in improving particle fluidity, in particular resisting
viscosity. The preparation is good in stability, good in releasing rate, and is beneficial to clinical use. The method is easy to operate, is suitable for large-scale industrial production, and has a higher application value.