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Preparation method of metoprolol tartrate sustained release tablets

A technology for metoprolol tartrate and torolol sustained-release tablets is applied in the field of preparation of metoprolol sustained-release tablets, and can solve the problems of low reproducibility of the prescription process, unstable quality and the like

Inactive Publication Date: 2014-09-17
NANJING REAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the open literature reports that the reproducibility of the prescription process for the preparation of metoprolol tartrate sustained-release tablets is not high, and the quality is unstable

Method used

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  • Preparation method of metoprolol tartrate sustained release tablets
  • Preparation method of metoprolol tartrate sustained release tablets
  • Preparation method of metoprolol tartrate sustained release tablets

Examples

Experimental program
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Embodiment 1

[0028]

[0029] Process:

[0030] Sieving: pass the metoprolol tartrate, microcrystalline cellulose, and HPMCK15 through an 80-mesh sieve respectively, and set aside.

[0031] Weighing: Metoprolol tartrate, microcrystalline cellulose, and HPMCK15 were weighed according to the prescription amount.

[0032] Powder mixing: Pour metoprolol tartrate, microcrystalline cellulose, and HPMCK15 into a granulator and mix for 30 minutes.

[0033] Granulation: 10% PVP-K30 ethanol solution is made into a soft material, and granulated with a 20-mesh nylon sieve.

[0034] Drying: Dry the prepared granules in an oven at 60°C.

[0035] Grain sizing: The dried granules are sieved with a 20-mesh stainless steel sieve.

[0036] Blending: adding silicon dioxide and magnesium stearate for blending.

[0037] Intermediate inspection: take a sample to determine the percentage of metoprolol tartrate in the mixed powder, and calculate the tablet weight from the following formula:

[0038] Tablet ...

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Abstract

The invention provides a preparation method of metoprolol sustained release tablets and in particular relates to a preparation method of metoprolol tartrate sustained release tablets. A framework material of a specific model number is adopted and the sustained release tablets are prepared according to a fixed ratio; the obtained sustained release tablets are stable and reliable in quality.

Description

technical field [0001] The invention relates to a preparation method of metoprolol sustained-release tablets, in particular to a preparation method of metoprolol tartrate sustained-release tablets. Background technique [0002] Metoprolol is a long-acting preparation of a cardioselective β1-blocker. For hypertensive patients, it can significantly lower blood pressure, but it does not cause orthostatic hypotension and electrolyte disturbance; for patients with angina pectoris, it can reduce the number of attacks and improve exercise tolerance. Metoprolol tartrate has ordinary tablets, controlled-release tablets and sustained-release tablets. Due to different dosage forms, the drug release speed and absorption mode after taking are different. Sustained-release preparations refer to preparations that can continuously release drugs for a long period of time after administration to achieve long-acting effects. The drug release of sustained-release tablets is mainly a first-order...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/138A61K47/38A61P9/12
Inventor 张斌于居超李玉凤相文杰
Owner NANJING REAL PHARMA
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