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Compound preparation containing benidipine hydrochloride and metoprolol tartrate and application thereof

A technology of metoprolol tartrate and benidipine hydrochloride, which is applied in the field of biomedicine, can solve the problems of inaccurate dosage, increased side effects of drugs, and influence on drug efficacy, so as to improve the antihypertensive effect, reduce the dosage of drugs, Enhanced effect of treatment

Inactive Publication Date: 2012-03-21
山东新宝医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] When using benidipine hydrochloride or metoprolol tartrate clinically now, there are often the following problems: 1. When a single drug is used, the dosage of the drug must be increased to ensure the curative effect, which will inevitably lead to a significant increase in the side effects of the drug; 2. When taking medication, because there is no pharmaceutical preparation that meets the dosage of the combined medication, the dosage used for clinical use is inaccurate, which affects the efficacy of the medication

Method used

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  • Compound preparation containing benidipine hydrochloride and metoprolol tartrate and application thereof
  • Compound preparation containing benidipine hydrochloride and metoprolol tartrate and application thereof
  • Compound preparation containing benidipine hydrochloride and metoprolol tartrate and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0020] 1 part by weight of benidipine hydrochloride, 25 parts by weight of metoprolol tartrate, 30.5 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 100 parts by weight of pregelatinized starch, 15 parts by weight of sodium starch glycolate, croscarmellose 10 parts by weight of sodium cellulose, 2.5 parts by weight of hypromellose, and 1 part by weight of magnesium stearate.

[0021] The raw materials and auxiliary materials are respectively pulverized through 80-mesh sieves, and the hypromellose is prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, mix other raw and auxiliary materials uniformly by the method of equal incremental dilution, use the prepared adhesive to make a soft material, pass through a 18-mesh sieve for granulation, fully dry at 60°C, and granulate with an 18-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat. ...

Embodiment 2

[0023] 2 parts by weight of benidipine hydrochloride, 25 parts by weight of metoprolol tartrate, 30 parts by weight of microcrystalline cellulose, 43 parts by weight of pregelatinized starch, 20 parts by weight of sodium carboxymethyl starch, 3 parts by weight of povidone K30, hard 2 parts by weight of magnesium fatty acid.

[0024] The raw materials and auxiliary materials were crushed through an 80-mesh sieve, and the povidone K30 was prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed uniformly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 20-mesh sieve, fully dried at 65°C, and granulated with a 20-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat. Each tablet contains 2 mg of benidipine hydrochloride and 25 mg of metoprolol tartrate.

Embodiment 3

[0026] 2 parts by weight of benidipine hydrochloride, 25 parts by weight of metoprolol tartrate, 30 parts by weight of lactose, 25 parts by weight of microcrystalline cellulose, 10.5 parts by weight of pregelatinized starch, 10 parts by weight of sodium carboxymethyl starch, croscarmellose 18 parts by weight of sodium cellulose, 3 parts by weight of hypromellose, and 1.5 parts by weight of magnesium stearate.

[0027] The raw materials and auxiliary materials are respectively crushed through an 80-mesh sieve, and the hypromellose is prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed evenly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 18-mesh sieve, fully dried at 70°C, and granulated with an 18-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and co...

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Abstract

The invention discloses a compound preparation containing benidipine hydrochloride and metoprolol tartrate and an application thereof; for the preparation, the benidipine hydrochloride and the metoprolol tartrate are taken as active pharmaceutical ingredients. The compound pressure-reducing preparation adopts drug combination and is good in efficacy, less in side effects and high in performance-price ratio; the compound preparation is taken once per day, the administration is convenient and the drug compliance of a patient can be improved. The preparation can be prepared into oral formulations in different forms, thereby realizing synergic and complementary action of drugs and enhancing the treatment effect of the compound preparation. The compound preparation has significant effects for treating hypertension and can also be used for treating angina pectoris, myocardial infarction and arrhythmia, as well as hypertrophic cardiomyopathy, aortic dissection, hyperthyroidism, cardiac neurosis, chronic stable heart failure and other symptoms. The compound preparation is low in price, simple to prepare and convenient to popularize and apply.

Description

technical field [0001] The invention relates to a compound preparation and an application thereof, in particular to a compound preparation containing benidipine hydrochloride and metoprolol tartrate and an application thereof, belonging to the technical field of biomedicine. Background technique [0002] Hypertension is the most prevalent disease in the world today, known as the "silent killer". Due to the development of social economy and the change of people's life style, the prevalence of hypertension in our country shows a continuous growth trend, and it has become one of the important public health problems in our country. The task of prevention and treatment of hypertension in our country is arduous. In the third national sample survey in 1991, a total of more than 900,000 people over the age of 15 were surveyed. The results showed that the crude prevalence rate of hypertension was 13.58%. During the 10 years from 1980 to 1991, the prevalence of hypertension in the Ch...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K31/138A61P9/12
Inventor 马全龙初茂忠王浩骅许东升孙山王淑云梁海勇
Owner 山东新宝医药有限公司
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