39results about How to "System transparency" patented technology

The invention discloses a slippery water fracturing fluid with ultra-low interfacial tension with crude oil after degradation. The slippery water fracturing fluid is prepared from an ultra-low interfacial tension drag reducer, a demulsify-cleanup additive, a clay stabilizer and a degrading agent. A preparation method of the slippery water fracturing fluid comprises steps as follows: 0.02%-0.10% in percentage by mass of the ultra-low interfacial tension drag reducer, 0.1%-0.2% in percentage by mass of the demulsify-cleanup additive and 0.3% in percentage by mass of the clay stabilizer are added to every ton of water, the agents are mixed to form a homogeneous solution, and 0.08% of the degradation agent is added from a mixing tank of blending equipment during construction. Additives of the slippery water fracturing fluid are all liquid phase, and the slippery water fracturing fluid can be quickly dispersed in water, have good salt tolerance, are not easily affected by the content of bacteria in a fluid preparation solution and have a stable drag reduction effect under the construction displacement of 6-20 m<3> / min; when applied to improvement of low-permeability oil and gas reservoirs, the slippery water fracturing fluid can reduce the interfacial tension between a gel breaking liquid and crude oil and reduce string and construction friction, helps production of the crude oil, increases of the yield of the crude oil and can be prepared repeatedly from backflow fracturing fluids.

The invention provides a preparation method for a single-component POSS / addition type silicon resin nanocomposite. The method comprises the following steps: double-bond-contained polyhedral oligomeric silsesquioxane (POSS) is synthesized, a silanol mixed solution containing different functional groups is prepared, and the double-bond-contained polyhedral oligomeric silsesquioxane (POSS) reacts with the silanol mixed solution to generate the target product namely single-component POSS / addition type silicon resin nanocomposite. The method comprises the following steps: (1), synthesizing the double-bond-contained polyhedral oligomeric silsesquioxane (POSS); (2) synthesizing silanol; (3), adding the double-bond-contained polyhedral oligomeric silsesquioxane (POSS) with different content, which is obtained through the step (1), into the silanol mixed solution obtained through the step (2), and reacting continuously for a period of time, so that a POSS / silicon resin nanocomposite prepolymer is obtained, then adding an end-capping agent, reducing pressure for removing low-molecular-weight by-products and absolute ethyl alcohol, and adding a cross-linking agent, a catalyst and an inhibitor auxiliary, so that the single-component POSS / addition type silicon resin nanocomposite is obtained.

The invention discloses a compound apigenin nanoemulsion antihypertensive drug which comprises the following raw materials in mass percent: 1-15% of apigenin, 5-35% of surfactant, 1-20% of cosurfactant, 1-20% of oil, 0.5-10% of motherwort fruit aqueous extract, 0.5-10% of semen cassiae water extract and the balance of distilled water; and the sum of mass percents of the above raw materials is 100%. The nanoemulsion is small in emulsion droplet, uniform in distribution, low in viscosity and good in liquidity. After apigenin is prepared into a nanoemulsion, blood brain barrier transmission capacity is obviously increased, the bioavailability of a technical material is obviously improved, the half-life period of the drug can be prolonged; and the drug administration times can be reduced; with adoption of the nanoemulsion, the dissolution and infiltration capacity of atenolol can be improved and the stability of apigenin is increased; and the nanoemulsion has obvious synergistic effect compounded with the motherwort fruit and the semen cassiae; and the medicinal cure effect can be more fully played.

The invention discloses a compound anti-aging quercetin nanoemulsion health care product which comprises the following raw materials in mass percent: 1-15% of quercetin, 15-40% of surfactant, 1-15% of cosurfactant, 5-25% of oil, 1-15% of celery aqueous extract, 1-15% of mushroom aqueous extract, and the balance of distilled water; and the sum of mass percents of the above raw materials is 100%. The nanoemulsion is small in emulsion droplet, uniform in distribution, low in viscosity and good in liquidity. The compound anti-aging health care product takes fat soluble natural product quercetin with an efficient anti-aging effect as a main component, takes the celery aqueous extract and the mushroom aqueous extract as auxiliary components, has effects of keeping skin moisture, adjusting slumber, delaying senescence and adjusting immunologic function and has certain health care effect on diseases such as hypertension, hyperlipemia, hyperglycemia, heart disease and the like.

The invention discloses a fipronil self-nanoemulsion solution, and a preparation method and an application thereof. The fipronil self-nanoemulsion solution is mainly prepared from, by weight, 1-20 parts of fipronil, 20-50 parts of an oily solvent, 40-80 parts of an emulsifier and 10-40 parts of a co-emulsifier. The oil-in-water fipronil nanoemulsion has the advantages of uniformity in distribution, good transparence and stability, low surface tension, good fluidity, convenience in use, narrow particle size distribution, small particle size, increase of the absorption rate of the effective component, and good in vitro permeability. The preparation method has the advantages of simplicity, convenience, and easiness in production and application; and the emulsion can be directly used in in-vitro parasite expelling of pets as a spray or a drop, and can be diluted with water to form the oil-in-water nanoemulsion having a small particle size, a good stability and a high pet skin permeabilityin order to expel in vitro parasites from the pets, and the above preparation is clinically used for treating the parasites of the pets.

The invention belongs to the technical field of food processing and particularly relates to oil-water-soluble rosemary extract and a preparation method and application thereof. The preparation methodcomprises mixing powdery rosemary extract and an extraction solvent, carrying out extraction and solid-liquid separation to obtain a clear liquid, concentrating the clear liquid to obtain rosemary extract, preheating the rosemary extract to 40-90 DEG C, adding an oil-soluble emulsifier and a water-soluble emulsifier into the extract, and carrying out stirring emulsification at 40-90 DEG C to obtain the oil-water-soluble rosemary extract. The preparation method has simple processes, utilizes a scientific and reliable principle and utilizes easily available raw materials. The oil-water-soluble rosemary extract is liquid and transparent, does not product precipitates, has good fluidity, can be fully dispersed in the oil phase or the water phase, is not layered after long-term standing, has good stability and can be widely used in the fields of oil, water and an oil-water mixture.

The invention relates to an anticoccidial compound origanum oil oral nano emulsion for poultry. The anticoccidial compound origanum oil oral nano emulsion is prepared from the following raw materials in percentage by weight: 1%-30% of origanum oil, 10%-40% of a surfactant, 1%-20% of a cosurfactant, 1%-20% of toosendanin, 1%-20% of a green tea extract, 1%-20% of lentinan, 0.1%-10% of procyanidine and the balance being water; the sum of the weight percentages of the raw materials is 100%. According to the oral nano emulsion, the origanum oil and the purely-natural plant extract are combined, and the oral nano emulsion with the formula is healthy and reasonable, has high safety, has double effects of health care and treatment and has an obvious anticoccidial curative effect.

The invention belongs to the technical field of food processing, and particularly relates to oil-soluble rosemary extract and a preparation method and application thereof. The preparation method includes: mixing powdery rosemary extract and an extraction solvent, and extracting; performing solid-liquid separation to obtain clear liquid; concentrating the clear liquid to obtain rosemary extract extractum; preheating the rosemary extract extractum to 40-90 DEG C, adding an oil soluble emulsifier, and stirring for emulsifying at 40-90 DEG C to obtain the oil soluble rosemary extract. The preparation method is simple in preparation process, scientific and reliable in principle and easy-to-get in raw material, the oil soluble rosemary extract is in a liquid state, transparent in system, free ofprecipitate, high in fluidity, completely dispersible in oil phase, free of layering after long-time placement and high in product stability and can be widely used in various application fields of oil-containing and oil-water mixed use.

The invention discloses an oil-in-water type sotalol nanoemulsion antihypertensive drug, the raw materials and the mass percentages of each raw material are: 1%-18% of sotalol, 15%-40% of surfactant, Co-surfactant is 0-25%, the rest is distilled water, and the sum of the mass percentages of the above-mentioned raw materials is 100%. The nano-emulsion emulsion has small particles, uniform distribution, low viscosity and good fluidity. After the water-soluble drug sotalol is prepared into nanoemulsion form, the stability and drug efficacy of sotalol are increased, the antihypertensive effect is obviously increased, the half-life of the drug is prolonged, and the number of administrations is reduced.

The invention discloses a propranolol-eugenol type basil oil nano-emulsion medicament, which consists of the following raw materials in percentage by mass: 1-10 percent of propranolol, 10-30 percent of surfactant, 0-25 percent of cosurfactant, 1-15 percent of eugenol type basil oil and the balance of distilled water, wherein the mass percentage sum of the raw materials is 100 percent. A nano-emulsion has the characteristics of small emulsion drop particles, uniform distribution, low viscosity and high flowability. In a nano-emulsion dosage form, propranolol serving as a water-soluble medicament is organically combined with fat-soluble eugenol type basil oil, so that the dissolving and permeation capabilities of eugenol type basil oil are increased, and the stability and medicament effect of propranolol are enhanced. After the propranolol and the eugenol type basil oil are prepared into a nano-emulsion dosage form, the advantages of the propranolol and the eugenol type basil oil are combined, the hypertension resisting effect is enhanced remarkably, the half-life period of a medicament is prolonged, and the administration times are reduced.

An oil-in-water type compound apramycin nano-emulsion belongs to the technical field of medicines, and is composed of the compositions in percent by weight: 1%-18% of apramycin, 1%-20% of rheum officinale extractive, 15%-40% of a surfactant, 1%-25% of an auxiliary surfactant, 1%-20% of oil and 20%-80% of distilled water. The compound apramycin bacteriostatic nano-emulsion is relatively narrow in emulsion particle size, transparent in system, good in stability, relatively low in surface tension, extremely good in fluidity and convenient to administrate. Because of the compounding of rheum officinale extractive and apramycin, the bacteriostatic effect is relatively good, and because of the nano-emulsion form, apramycin is relatively easy to absorb by bodies, and the usage amount and the usage frequency of the medicine can be reduced.

The invention discloses an oil-in-water type trimetaphan camsilate and linseed oil nanoemulsion antihypertensive drug which comprises the following raw materials in percentage by weight: 1%-15% of trimetaphan camsilate, 15%-35% of surfactant, 0-20% of cosurfactant, 1%-25% of linseed oil and the balance of distilled water, wherein the sum of the mass percent of the raw materials is 100%. The nanoemulsion has the advantages of small emulsion drop granule, uniform distribution, small viscosity and good flowability. In the nanoemulsion dosage form, the hydralazine which is a water-soluble medicine and the fat soluble linseed oil are organically combined, so the dissolving and infiltration capacities of the linseed oil are improved, and the stability and the pesticide effect of the trimetaphan camsilate are improved; and after the trimetaphan camsilate and the linseed oil are prepared into the nano dosage form, the advantages of the trimetaphan camsilate and the linseed oil are combined, so the antihypertensive effect is obviously increased, the half-life period of the drug is prolonged, and the drug administration times is reduced.

The invention disclose an oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament, which is a nanoemulsion medicament taking ceftiofur and a fructus psoraleae aqueous extract as effective components. The medicament comprises the following components in parts by weight: 1-25 parts of ceftiofur, 15-35 parts of a surfactant, 0-20 parts of a cosurfactant, 1-15 parts of a fructus psoraleae aqueous extract, 1-20 parts of oil, and 20-70 parts of distilled water. In the invention, through the combination of the ceftiofur and the fructus psoraleae aqueous extract, the medicament is good in effect, excellent in antibacterial effect, extremely simple in preparation method, and easier to popularize.

The invention relates to an oil-in-water type compound ceftriaxone nanoemulsion antimicrobial medicine which is a nanoemulsion preparation taking ceftriaxone and an aqueous extract of lotus leaves as effective components. The medicine is prepared from the following components in parts by weight: 1 to 25 parts of ceftriaxone, 15 to 35 parts of surfactant, 0 to 20 parts of cosurfactant, 1 to 20 parts of aqueous extract of lotus leaves, 1 to 20 parts of oil and 20 to 70 parts of distilled water. The medicine is good in pharmacological action and excellent in antimicrobial effect via combination of the ceftriaxone and the aqueous extract of lotus leaves, and is very simple in preparation method and easy to popularize.

An oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is a nanoemulsion medicament with cefazolin and an aqueous clove extract as effective components, and comprises the following components in parts by weight: 1-15 parts of cefazolin, 10-30 parts of a surfactant, 0-25 parts of a co-surfactant, 1-10 parts of aqueous clove extract, 1-20 parts of oil and 20-70 parts of distilled water. By compounding the cefazolin and the aqueous clove extract, the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is good in medicinal effect and good in antimicrobial effect; a preparation method is very simple; the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is easier to popularize.

The invention relates to an oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine which is a nanoemulsion preparation taking neomycin sulfate and nosiheptide as effective components. The antimicrobial medicine comprises the following components in parts by weight: 1 to 20 parts of neomycin sulfate, 15 to 35 parts of surfactant, 0 to 20 parts of cosurfactant, 1 to 25 parts of nosiheptide, 1 to 25 parts of oil and 20 to 70 parts of distilled water. The antimicrobial medicine has a good pharmacological function and an excellent antimicrobial effect via combination of neomycin sulfate and nosiheptide, and is very simple in preparation method and easy to popularize.

The invention discloses a compound alprenolol nano-emulsion antihypertensive drug. The drug comprises the following raw materials by weight: 0.1%-13% of alprenolol, 5%-45% of surfactant, 1%-25% of cosurfactant, 5%-35% of oil, 0-30% of cosolvent, 0.5%-15% of uncaria rhynchophylla water extract, 0.5%-15% of gastrodia elata water extract and the balance of distilled water, and the sum of the weight percents of the raw materials is 100%. The nano-emulsion drops are small in size, low in viscosity and good in flowability and can be distributed uniformly. Due to the nano emulsion, the drug dissolving and penetrating capability of the alprenolol is improved, the stability of the alprenolol is improved, and the capability of the alprenolol for passing through the blood brain barrier is improved. After the alprenolol is prepared to be nano emulsion, the antihypertensive effect is improved obviously, the half-life period of the drug is prolonged, and the times of administration are reduced. The compound alprenolol nano-emulsion antihypertensive drug has very broad market prospect.

The invention relates to an oil-in-water type compound minocyline antibacterial medicine and belongs to the technical field of medicines. Active ingredients of the oil-in-water type compound minocyline antibacterial medicine are minocyline and a ginkgo leaf aqueous extract. The oil-in-water type compound minocyline antibacterial medicine comprises the following active ingredients in parts by weight: 1-15 parts of a ginkgo leaf aqueous extract and 1-25 parts of minocyline; a dosage form of the oil-in-water type compound minocyline antibacterial medicine is nanoemulsion which comprises the following components in parts by weight: 1-15 parts of ginkgo leaf aqueous extract, 5-45 parts of surfactant, 0-45 parts of cosurfactant, 1-25 parts of minocyline, 1-20 parts of oil and 20-70 parts of distilled water. The obtained nanoemulsion is narrow in emulsion particle size distribution, transparent in system, good in stability, relatively low in surface tension, good in liquidity and easy to take, and the nanoemulsion preparation is used for improving dissolvability and permeability of minocyline, so that bioavailability of the medicine is improved; the ginkgo leaf aqueous extract and the minocyline are combined, and antibacterial activities of the ginkgo leaf aqueous extract and the minocyline can be mutually promoted and enhanced, and the antibacterial effect is more stable.

The invention discloses a benazepril hydrochloride-hyacinth oil nanoemulsion antihypertensive drug. Raw materials for the drug comprise, by mass percentage, 1% to 18% of benazepril hydrochloride, 15% to 40% of surfactant, 0 to 20% of cosurfactant and 1% to 20% hyacinth oil, with the balance being distilled water, wherein the sum of the mass percentage of the raw materials is 100%. Nanoemulsion provided in the invention has small and uniformly-distributed emulsion droplet particles, low viscosity and good fluidity. In the dosage form of nanoemulsion, the water-soluble drug benazepril hydrochloride and fat-soluble hyacinth oil are organically combined together, which improves the solubility and permeability of hyacinth oil and the stability and efficacy of benazepril hydrochloride. When the dosage form of nanoemulsion is prepared from benazepril hydrochloride and hyacinth oil, the advantages of both benazepril hydrochloride and hyacinth oil are combined; therefore, an antihypertensive effect of the drug provided in the invention is obviously improved, the half-life of the drug is prolonged, and administration frequency is reduced.

The invention discloses an oil-in-water type compound lomefloxacin nano-emulsion, belonging to the technical field of medicines. The nano-emulsion comprises the following components in parts by weight: 1-20 parts of herba houttuyniae aqueous extract, 5-40 parts of surfactant, 1-15 parts of co-surfactant, 1-25 parts of lomefloxacin, 1-25 parts of oil and 20-70 parts of water. The nano-emulsion disclosed by the invention is relatively narrow in latex particle size distribution, transparent in system and good in stability, has relatively low surface tension and very good fluidity, is convenient to take, and improves the solubility and penetrability of lomefloxacin to ensure that the bioavailability of a medicament is improved; and the herba houttuyniae aqueous extract is compounded with lomefloxacin, so that the antibacterial abilities of the two are mutually promoted, and the antibacterial effect is more stable.

The invention relates to compound tea polyphenol nano emulsion as well as a preparation method and application thereof. The compound tea polyphenol nano emulsion is stable in properties, a particle size is smaller than 100nm, the compound tea polyphenol nano emulsion belongs to a W / O-type tea polyphenol nano emulsion and is prepared from the following raw materials by weight percent: 1 to 20 percent of tea polyphenol, 15 to 50 percent of composite surfactant, 1 to 15 percent of absolute ethyl alcohol, 10 to 25 percent of oil, and the balance of deionized water, and the sum of the weight percent of the raw materials is 100 percent. The W / O nano emulsion is simple in preparation method, small in nano emulsion drop particles, uniform in distribution, small in viscosity, good in mobility, capable of improving the stability of the tea polyphenol in food and medicine preparation, and capable of enlarging the application range.

The invention discloses a compound quercetin nano-emulsion anti-aging health care product. The raw materials and mass percentages thereof are: 1% to 15% of quercetin, 15% to 40% of a surfactant, and 1% to 10% of a cosurfactant 15%, oil 5%-25%, celery water extract 1%-15%, mushroom water extract 1%-15%, the rest is distilled water, and the mass percentage sum of the above-mentioned raw materials is 100%. The nano-emulsion emulsion has small particles, uniform distribution, low viscosity and good fluidity. The present invention uses the fat-soluble natural product quercetin with high anti-aging effect as the main component, supplemented with celery water extract and mushroom water extract, and has the functions of maintaining skin moisture, regulating sleep, delaying aging, and regulating immune function. It has a certain health care effect on diseases such as high blood pressure, high blood fat, high blood sugar, and heart disease.

The invention provides a preparation method for a single-component POSS / addition type silicon resin nanocomposite. The method comprises the following steps: double-bond-contained polyhedral oligomeric silsesquioxane (POSS) is synthesized, a silanol mixed solution containing different functional groups is prepared, and the double-bond-contained polyhedral oligomeric silsesquioxane (POSS) reacts with the silanol mixed solution to generate the target product namely single-component POSS / addition type silicon resin nanocomposite. The method comprises the following steps: (1), synthesizing the double-bond-contained polyhedral oligomeric silsesquioxane (POSS); (2) synthesizing silanol; (3), adding the double-bond-contained polyhedral oligomeric silsesquioxane (POSS) with different content, which is obtained through the step (1), into the silanol mixed solution obtained through the step (2), and reacting continuously for a period of time, so that a POSS / silicon resin nanocomposite prepolymer is obtained, then adding an end-capping agent, reducing pressure for removing low-molecular-weight by-products and absolute ethyl alcohol, and adding a cross-linking agent, a catalyst and an inhibitor auxiliary, so that the single-component POSS / addition type silicon resin nanocomposite is obtained.

The invention discloses an oil-in-water type antihypertensive drug of enalapril and safflower oil nanoemulsion. The materials and the weight percentages of the materials are as follows: 1-20% of the enalapril, 15-35% of surfactant, 0-20% of cosurfactant, 1-25% of the safflower oil, and the balance of distilled water. The sum of the weight percentages of the materials is 100%. The nanoemulsion has the advantages of small emulsion droplet particles, uniform distribution, small viscosity and good flowability. With the adoption of the dosage form of the nanoemulsion, water-soluble enalapril and fat-soluble safflower oil are organically combined, so that the dissolving and penetrating abilities of the safflower oil are improved, and the stability and the pesticide effect of the enalapril are increased. The advantages of the enalapril and the safflower oil are combined after the enalapril and the safflower oil are prepared into nanoemulsion formulation, so that the antihypertensive effect is obviously increased, the half-life period of the drug is prolonged and the administration times are also reduced.

The invention discloses an oil-in-water type compound ramipril nano-emulsion, which is prepared from 1%-25% of ramipril, 0.1%-25% of hydralazine, 0.1%-25% of lisinopril, 10%-55% of surfactant, 5%-30% of oil and the balance distilled water, wherein the sum of the mass percent of the ingredients is 100%. The nano-emulsion is small in emulsion droplet granule, even in distribution, low in viscosity, and good in liquidity and has antihypertensive capacity, the dissolubility of the ramipril is enhanced, the bioavailability and the drug stability of the ramipril are improved, the metabolic time of the nano-emulsion in vivo is delayed, and the problem of hypertension can be synthetically solved because the hydralazine and the lisinopril are synthesized. With the adoption of the compound ramipril nano-emulsion, the dosage of the adjuvants of the antihypertension is reduced, the toxicity of the antihypertension to body is lowered, and the production cost is lowered; and furthermore, the preparation method of the compound ramipril nano-emulsion is simple and is low in energy consumption.

The invention belongs to the field of veterinary medicines, and particularly discloses oil-in-water type Febantel nanoemulsion and a method for preparing the same. The oil-in-water type Febantel nanoemulsion comprises, by weight, 1-20% of Febantel, 25-45% of surfactant, 0-20% of co-surfactant, 1-20% of oil and the balance water. The surfactant is EL40, the co-surfactant is absolute ethyl alcohol,and the oil is fatty glyceride. The oil-in-water type Febantel nanoemulsion and the method have the advantages that the oil-in-water type Febantel nanoemulsion is uniformly distributed and is low in surface tension, excellent in flowability and convenient to administer, and systems are transparent and are good in stability; the oil-in-water type Febantel nanoemulsion can be quickly swallowed by reticuloendothelial cells after being administrated, accordingly, effects of medicines can be quickly realized, constant blood concentration and pharmacological effects can be maintained, the bioavailability of the medicines can be improved, the efficacy can be enhanced, and the dosage and use frequencies of the medicines can be reduced.

The invention relates to a methanol gasoline composite additive, and a preparation method and application thereof. The methanol gasoline composite additive is prepared from the following raw materials in percentage by weight: 68 to 72 percent of animal oil, 0.5 to 1.0 percent of plant oil, 0.2 to 0.5 percent of alkylbenzene, 0.1 to 0.7 percent of monoethanolamine, 0.1 to 0.7 percent of diethanolameine, 0.1 to 0.6 percent of triethanolamine, 1.0 to 2.1 percent of isooctyl nitrate, 1.0 to 2.1 percent of isopropyl nitrate, 1.0 to 2.1 percent of ethyl nitrate, 1.0 to 2.1 percent of sodium hydroxide, 1.0 to 2.1 percent of potassium hydroxide and 18 to 22 percent of water. According to the preparation method, the raw materials are sequentially put into a mixing container according to the proportion, and are stirred at the same time; then, the mixing container is put into ultrasonic waves, and agitation is performed for 15 to 25 min; and the composite additive is obtained. The composite additive provided by the invention can be applied to M25 to M60; the corrosion of methanol gasoline on an automobile can be reduced; and the octane value, the blasting point, the combustion heat value, the oil product quality and the power of the methanol gasoline can be improved.

The invention discloses an oil-in-water type metoprolol tartrate / seabuckthorn oil nanoemulsion antihypertensive drug which is characterized in that the nanoemulsion antihypertensive drug has particle size of 30.1-71.8 nm. The drug comprises the following raw materials by weight: 1-20% of metoprolol tartrate, 15-40% of surfactant, 1-25% of co-surfactant, 1-25% of seabuckthorn oil, and the balance of distilled water. The sum of the mass percent of the raw materials is 100%. The nanoemulsion preparation organically combines water-soluble drug metoprolol tartrate and lipid-soluble seabuckthorn oil, to improve dissolution and penetration abilities of seabuckthorn oil, and improve stability and medicinal effect of metoprolol tartrate. The metoprolol tartrate / seabuckthorn oil nanoemulsion combines advantages of metoprolol tartrate and seabuckthorn oil to obviously improve antihypertensive effect, prolong half life of drug, and reduce administration times.