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Oil-in-water type compound minocyline antibacterial medicine

An antibacterial drug, minocycline technology, applied in the field of medicine, can solve the problems of reduced drug bioavailability, slow drug dissolution rate, inconvenient use, etc. Effect

Inactive Publication Date: 2015-01-14
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets or capsules are convenient to take orally, but the dissolution rate of the drug is slow, coupled with the liver’s first-pass effect on the drug, resulting in a decrease in the bioavailability of the drug; although injections can avoid the first-pass effect, it is inconvenient to use and difficult to operate. It will bring pain to the patient, such as local redness, swelling and pain

Method used

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  • Oil-in-water type compound minocyline antibacterial medicine
  • Oil-in-water type compound minocyline antibacterial medicine
  • Oil-in-water type compound minocyline antibacterial medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0033] An oil-in-water type compound minocycline antimicrobial drug, its weight composition is: 7 parts of ginkgo biloba water extract, 24 parts of surfactant (EL40), 13 parts of co-surfactant (ethanol), minocycline 6 parts, oil (castor oil) 11 parts, distilled water 39 parts.

[0034] Its preparation method is as follows:

[0035] 1) Weigh minocycline, oil, surfactant and co-surfactant, water extract of Ginkgo biloba and water according to the above weight ratio; 2) Mix minocycline, surfactant and co-surfactant at room temperature Stir the agent evenly to obtain an oil phase solution;

[0036] 3) Dissolving the water extract of ginkgo biloba in water to obtain an aqueous phase solution;

[0037] 4) Add the aqueous phase solution to the oil phase solution, and stir evenly to obtain nanoemulsion.

Embodiment 2

[0039] An oil-in-water type compound minocycline antimicrobial drug, which consists of 6 parts of water extract of ginkgo biloba, 34 parts of surfactant (EL40), 10 parts of cosurfactant (1,2-propylene glycol), Minocycline 5.5 parts, oil (isopropyl myristate) 14 parts, distilled water 30.5 parts.

[0040] Its preparation method is with embodiment 1.

Embodiment 3

[0042] An oil-in-water type compound minocycline antibacterial drug, its weight composition is: 4.5 parts of ginkgo biloba water extract, 30 parts of surfactant (RH40), 25 parts of co-surfactant (glycerol), minocycline Cyclocycline 5.5 parts, oil (fatty acid glyceride) 10 parts, distilled water 25 parts.

[0043] Its preparation method is with embodiment 1.

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Abstract

The invention relates to an oil-in-water type compound minocyline antibacterial medicine and belongs to the technical field of medicines. Active ingredients of the oil-in-water type compound minocyline antibacterial medicine are minocyline and a ginkgo leaf aqueous extract. The oil-in-water type compound minocyline antibacterial medicine comprises the following active ingredients in parts by weight: 1-15 parts of a ginkgo leaf aqueous extract and 1-25 parts of minocyline; a dosage form of the oil-in-water type compound minocyline antibacterial medicine is nanoemulsion which comprises the following components in parts by weight: 1-15 parts of ginkgo leaf aqueous extract, 5-45 parts of surfactant, 0-45 parts of cosurfactant, 1-25 parts of minocyline, 1-20 parts of oil and 20-70 parts of distilled water. The obtained nanoemulsion is narrow in emulsion particle size distribution, transparent in system, good in stability, relatively low in surface tension, good in liquidity and easy to take, and the nanoemulsion preparation is used for improving dissolvability and permeability of minocyline, so that bioavailability of the medicine is improved; the ginkgo leaf aqueous extract and the minocyline are combined, and antibacterial activities of the ginkgo leaf aqueous extract and the minocyline can be mutually promoted and enhanced, and the antibacterial effect is more stable.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oil-in-water nanoemulsion—a compound antibacterial nanoemulsion with minocycline and ginkgo biloba water extract as active ingredients. Background technique [0002] Minocycline, also known as minocycline or minocycline, is a broad-spectrum antibacterial tetracycline antibiotic. Can combine with tRNA to achieve antibacterial effect. Minocycline has a broader antibacterial spectrum than similar drugs and has antibacterial activity. The antibacterial spectrum is similar to that of tetracycline, and it has a strong effect on Gram-positive bacteria, including tetracycline-resistant Staphylococcus aureus, Streptococcus and Neisseria gonorrhoeae in Gram-negative bacteria; the effect on Gram-negative bacilli is generally weak ; Chlamydia trachomatis and mycoplasma urealyticum also have a good inhibitory effect. [0003] At present, the dosage forms of minocycline anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/107A61P31/04A61K31/65
CPCA61K36/16A61K9/0053A61K9/1075A61K31/65A61K47/08A61K47/10A61K47/12A61K47/14A61K47/34A61K47/44A61K2236/331
Inventor 孙江宏岳旭龙王胜乐
Owner HENAN SOAR VETERINARY PHARMA
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