Oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament

A technology of ceftiofur and antibacterial drugs, applied in the field of medicine, can solve problems such as occasional angioedema, asthma and hypotension, erythema and urticaria, itching, drug fever, phlebitis or thrombophlebitis in response , to achieve the effects of reducing the first-pass effect, promoting gastrointestinal absorption, and taking convenience

Inactive Publication Date: 2015-01-14
HENAN SOAR VETERINARY PHARMA
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AI Technical Summary

Problems solved by technology

Drugs are mostly administered intravenously or intramuscularly. After intravenous administration, local reactions include phlebitis or thrombophlebitis. Intramuscular injection can cause severe pain, erythema and urticaria, itching, drug fever, and occasionally angioedema , asthma and hypotension and other allergic reactions; oral ceftiofur can be absorbed from the gastrointestinal tract, but the absorption is incomplete, the drug dissolution rate is slow, and the bioavailability rate is poor. Salivary amylase partially degrades and inactivates the drug when it is taken orally. There are adverse reactions of gastrointestinal reactions such as nausea, vomiting and diarrhea
In addition, the extensive use of antibiotics is also the direct cause of the increase in strain resistance

Method used

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  • Oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament
  • Oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament
  • Oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament

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Embodiment example

[0032] Table 1 Implementation Case Recipe

[0033] Example Ceftiofur / g Psoralen water extract / g Surfactant / g Co-surfactant / g oil / g water / g 1 6.2 6.3 25 (EL-40) 5 (ethanol) 12 (castor oil) 45.5 2 5.5 5.8 20 (EL-40) 15 (1,2-propanediol) 12 (ethyl butyrate) 41.7 3 4.7 5.9 20 (RH-40) 15 (glycerol) 12 (linoleic acid) 42.4 4 3.8 5.2 32 (RH-40) 4 (ethanol) 12 (ethyl formate) 43 5 3.3 7 27 (tween 80) 3 (glycerol) 12 (cinnamaldehyde) 47.7 6 6.5 8.3 15 (poloxamer 188) 10 (polyethylene glycol 400) 12 (soybean oil) 48.2

[0034] Preparation method: Accurately weigh ceftiofur, surfactant and co-surfactant, stir evenly at room temperature (25°C), and then slowly drop into it the distilled water that has been dissolved in the water extract of psoralen; When the amount of distilled water increases, the viscosity of the system increases. When the amount of distilled water is added to make the...

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Abstract

The invention disclose an oil-in-water type compound ceftiofur nanoemulsion antimicrobial medicament, which is a nanoemulsion medicament taking ceftiofur and a fructus psoraleae aqueous extract as effective components. The medicament comprises the following components in parts by weight: 1-25 parts of ceftiofur, 15-35 parts of a surfactant, 0-20 parts of a cosurfactant, 1-15 parts of a fructus psoraleae aqueous extract, 1-20 parts of oil, and 20-70 parts of distilled water. In the invention, through the combination of the ceftiofur and the fructus psoraleae aqueous extract, the medicament is good in effect, excellent in antibacterial effect, extremely simple in preparation method, and easier to popularize.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a compound ceftiofur antibacterial drug, in particular to an oil-in-water type compound ceftiofur nanoemulsion antibacterial drug. Background technique [0002] Ceftiofur (Ceftiofur), the chemical name is [6R-[6a,7β(Z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]yl]-3 -[[(2-furancarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, the third generation Cephalosporin antibiotics, a broad-spectrum antibacterial drug, have strong antibacterial activity against many Gram-positive and negative bacteria, including lactamase-producing strains and some anaerobic bacteria. The drug acts on transpeptidase to block the synthesis of bacterial cell walls and presents a bactericidal effect. Clinically, it is widely used in severe bacterial infections sensitive to ceftiofur and various symptoms caused by Escherichia coli and Salmonella. [0003] Ceftiofur ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K36/487A61P31/04A61K31/546
Inventor 孙江宏阮心洁
Owner HENAN SOAR VETERINARY PHARMA
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