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Oil-in-water type compound apramycin nano-emulsion

An apramycin, oil-in-water type technology, applied in the field of medicine, can solve the problems of inability to obtain curative effect, single action effect of apramycin, unsatisfactory preparation type, etc., achieve better bacteriostatic effect, maintain blood medicine Concentration and pharmacological effect, the effect of improving bioavailability

Active Publication Date: 2014-09-10
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition to the unsatisfactory types of existing preparations, apramycin alone has a single effect and cannot obtain a more ideal curative effect

Method used

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  • Oil-in-water type compound apramycin nano-emulsion
  • Oil-in-water type compound apramycin nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of oil-in-water type compound apramycin nanoemulsion, its percentage by weight is composed of: apramycin 7.6%, rhubarb extract 6.3%, EL-40 (surfactant) 24%, ethanol (cosurfactant ) 4%, ethyl acetate (oil) 13%, distilled water 45.1%.

[0025] Weigh 6.3g of rhubarb extract and dissolve in 45.1g of distilled water; weigh 7.6g of apramycin, 24g of EL-40, and 4g of ethanol and stir evenly at room temperature (25°C), then slowly drop in the dissolved rhubarb extract of distilled water. As the amount of distilled water increases, the viscosity of the system increases; when the amount of distilled water added makes the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state, and at this time It is colorless and transparent compound apramycin nanoemulsion.

Embodiment 2

[0027] An oil-in-water type compound apramycin nanoemulsion, which is composed of: 5.3% apramycin, 9.5% rhubarb extract, 25% EL-40 (surfactant), 1,2-propanediol ( co-surfactant) 15%, ethyl oleate (oil) 14%, distilled water 31.2%.

[0028] Its preparation method refers to embodiment 1.

Embodiment 3

[0030] An oil-in-water type compound apramycin nanoemulsion, which is composed of: 1.2% apramycin, 4.3% rhubarb extract, 30% RH-40 (surfactant), glycerol (surface aid) active agent) 15%, isopropyl myristate (oil) 19%, distilled water 30.5%.

[0031] Its preparation method refers to embodiment 1.

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Abstract

An oil-in-water type compound apramycin nano-emulsion belongs to the technical field of medicines, and is composed of the compositions in percent by weight: 1%-18% of apramycin, 1%-20% of rheum officinale extractive, 15%-40% of a surfactant, 1%-25% of an auxiliary surfactant, 1%-20% of oil and 20%-80% of distilled water. The compound apramycin bacteriostatic nano-emulsion is relatively narrow in emulsion particle size, transparent in system, good in stability, relatively low in surface tension, extremely good in fluidity and convenient to administrate. Because of the compounding of rheum officinale extractive and apramycin, the bacteriostatic effect is relatively good, and because of the nano-emulsion form, apramycin is relatively easy to absorb by bodies, and the usage amount and the usage frequency of the medicine can be reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel antibacterial drug—oil-in-water compound apramycin nanoemulsion. Background technique [0002] Apramycin, also known as apramycin, is a new aminoglycoside veterinary antibiotic produced by Streptomyces obscurus. Apramycin was successfully developed by the United States in the 1980s. It has a strong antibacterial effect on Gram-negative bacteria, especially Escherichia coli and Salmonella, which are resistant to other antibiotics. Bacteria (some Streptococcus), Treponema and some Mycoplasma also have good antibacterial effect. Apramycin is characterized by a wide antibacterial spectrum and is not easy to produce drug resistance. It can be used for infections caused by chicken Escherichia coli, Salmonella and mycoplasma. As a drug-type feed additive, apramycin can significantly promote weight gain and improve feed conversion rate, and is widely used in the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/107A61P31/04A61K31/7036
Inventor 孙江宏王胜乐管倩
Owner HENAN SOAR VETERINARY PHARMA
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