Oil-in-water type compound ceftriaxone nanoemulsion antimicrobial medicine

Abstract

The invention relates to an oil-in-water type compound ceftriaxone nanoemulsion antimicrobial medicine which is a nanoemulsion preparation taking ceftriaxone and an aqueous extract of lotus leaves as effective components. The medicine is prepared from the following components in parts by weight: 1 to 25 parts of ceftriaxone, 15 to 35 parts of surfactant, 0 to 20 parts of cosurfactant, 1 to 20 parts of aqueous extract of lotus leaves, 1 to 20 parts of oil and 20 to 70 parts of distilled water. The medicine is good in pharmacological action and excellent in antimicrobial effect via combination of the ceftriaxone and the aqueous extract of lotus leaves, and is very simple in preparation method and easy to popularize.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a compound ceftriaxone antibacterial drug, in particular to an oil-in-water type compound ceftriaxone nanoemulsion antibacterial drug. Background technique [0002] Ceftriaxone generally refers to ceftriaxone sodium, ceftriaxone sodium (Ceftriaxone Sodium), also known as ceftriaxone, the chemical name is (6R,7R)-7-[[(2-amino-4-thiazolyl) Oxyimino)acetyl]amino]-8-oxo-3-[[1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazine -3-yl)thio]methyl]-5-thio-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt, a third-generation cephalosporin antibiotic , has bactericidal effect on many Gram-positive bacteria, negative bacteria and anaerobic bacteria. The improved structure of methoxyimine lies in the stability of β-lactamase secreted by Gram-negative bacteria. This special stability can increase the resistance of ceftriaxone against Gram-negative bacteria; replace cefotaxime Easily hydr...

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Problems solved by technology

Drugs are mostly administered intravenously or injected intramuscularly. After intravenous administration, local reactions include phlebitis, and intramuscular injection can cause severe pain, and may also have allergic reactions such as rash, itching, fever, bronchospasm, and serum sickness; oral ceftriaxone can Absorbed from the gastrointestinal tract, but the absorption is incomplete, the dissolution rate of the drug is slow, and the bioavailability rate is poor. Salivary amylase partially degrades and inactivates the drug when it is taken orally. At the same time, there are diarrhea, nausea, vomiting, abdominal pain, colitis, and jaundice. Adverse reactions of gastrointestinal reactions such as flatulence, dysgeusia and indigestion

In addition, the extensive use of antibiotics is also the direct cause of the increase in strain resistance

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