695results about How to "Synthesis fast" patented technology

The presently disclosed subject matter provides functional perfluoropolyether (PFPE) materials for use in fabricating and utilizing microscale devices, such as a microfluidic device. The functional PFPE materials can be used to adhere layers of PFPE materials to one another or to other substrates to form a microscale device. Further, the presently disclosed subject matter provides a method for functionalizing the interior surface of a microfluidic channel and / or a microtiter well. Also the presently disclosed subject matter provides a method for fabricating a microscale structure through the use of a sacrificial layer of a degradable material.

The invention relates to a method of synthesizing Beta molecular sieve without organic templates, which belongs to the technical field of catalytic chemistry. The steps of the invention comprise mixing alkali oxide sources, alumina sources, silica sources and water, stirring and synthesizing initial silica-alumina gel, then adding with Beta zeolite crystal seed, crystallizing 12-24 hours under the temperature of 100-180 DEG C and hydro-thermally synthesizing the Beta molecular sieve, SiO2 / Al2O3 of the Beta zeolite crystal seed equals 22-25, and the quality of addition quantity is 5%-20% of the silica sources. The method of the invention suits requirements of applying zeolite molecular sieve in industry, not only can directly synthesize high crystallinity crystal of the Beta molecular, but also can increase crystallizing speed of the molecular and reduce manufacturing cost. Because the synthesis process doesn't use any organic templates without roasting, thereby a pore path is unimpeded, and environmental pollution and relatively consumption are avoided.

Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. The plurality of samples is then formed into a plurality of films. Thereafter, the plurality of films is plastically deformed. Preferably, the plurality of films is deformed into a configuration appropriate for testing of properties or characteristics of the samples.

A rapid, simple and versatile metal organic framework molecule (MOF) synthesis method particularly adapted to make non-linear MOFs includes heating MOF precursors, such as a metal or metal oxide and an organic ligand, in a microwave oven for a period sufficient to achieve crystallization. Microwave-assisted MOF synthesis yields high quality MOF crystals in a reaction time ranging from about 5 seconds to about 2.5 minutes, compared to hours and days required in conventional solvothermal and hydrothermal methods. In addition, microwave assisted methods provide MOF materials with uniform crystal size and well-defined shape. Further, microwave synthesis of MOFs allows the size and shape of MOF crystals to be tailored for use in a wide range applications by manipulating reaction conditions. Secondary growth processes may also be employed to grow larger crystals using seeds obtained from microwave-assisted synthesis methods.

Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula:wherein X is OH, C1-C6 alkoxyl; Y and Z are independently selected from a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.

Simulation and analysis of conceptual flight vehicles in an early design phase is conducted in a framework for evaluating performance and control effectiveness that is captured by multiple design parameters modeling the effects of control and disturbance moments and forces acting upon a conceptual flight vehicle along a specified trajectory. Characteristics of multiple types of flight vehicle effectors are modeled as a system and adjusted in such a framework to converge to a controllable air frame configuration for conceptual flight vehicle under static design considerations prior to performing dynamic analyses and control system simulations.

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), or formula (II); wherein X is OH, C1-C6 alkoxyl, 18F, or 19F; Y and Z are independently selected from a C1-C6 alkyl, CpC6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H, X is not OH.

In a mixed reality display system having a video see-through HMD (head mounted display) and a virtual-space image generation unit, a synthesis processing unit for synthesizing a virtual-space image generated by the virtual-space image generation unit and an image captured by the video see-through HMD is provided on the side of the video see-through HMD, and a part of the captured image is transmitted to the virtual-space image generation unit for detecting a marker, so that a communication amount between the virtual-space image generation unit and the video see-through HMD is reduced.

Systems and methods for specifying, modelings simulating, and implementing a circuit design using a circuit design database comprising re-usable program elements to represent circuit design elements. The re-usable program elements may be used to build an overall circuit design description in the database. In example embodiments, the circuit design may be structured as a computer program and library to deterministically specify the circuit design elements to be used. Circuit synthesis functionality and circuit simulation functionality may be embedded as part of the re-usable program elements. Libraries may be compiled with the computer program instructions specifying the circuits to generate an executable that can be used for synthesis and simulation The combined executable code may be executed on an instruction set processor directly or through an interpreter.

Synthesis of long chain molecules such as DNA is carried out rapidly and efficiently to produce relatively large quantities of the desired product. The synthesis of an entire gene or multiple genes formed of many hundreds or thousands of base pairs can be accomplished rapidly and, if desired, in a fully automated process requiring minimal operator intervention, and in a matter of hours, a day or a few days rather than many days or weeks. Production of a desired gene or set of genes having a specified base pair sequence is initiated by analyzing the specified target sequence and determining an optimal set of subsequences of base pairs that can be assembled to form the desired final target sequence. The set of oligonucleotides are then synthesized utilizing automated oligonucleotide synthesis techniques. The synthesized oligonucleotides are subsequently selectively released from the substrate and used in a sequential assembly process.

The present invention relates to method of synthesizing nano grade titanium carbide by using microwave, it is proceeded as follows: titanium dioxide and acetylene carbon black are over dried to form raw material, then the raw material: zirconium pellet: absolute ethyl alcohol are mixed in ratio 1:1-5:3-6, and ground in ball mill to unifom, over dried microwave heating and synthesizing to obtain product, advantages include: low reaction temperature, simple technological process, easy to control, the obtained TiC powder is not easy to agglomerate, no impurity etc.

The invention discloses a preparation method of hydroxamic acid or hydroxamic acid salt. The method comprises the steps of adding alkaline into a methanol solution of a hydroxylamine salt under a stirring condition, then, adding organic carboxylic acid methyl ester to react, distilling to recover methanol after the reaction is ended to obtain a product hydroxamic acid salt; or cooling a reaction system after the reaction is ended, adding concentrated sulfuric acid into the reaction system, and distilling to recover methanol to obtain hydroxamic acid. The method can be used for greatly increasing the yield of hydroxamic acid or hydroxamic acid salt; methanol as a solvent can be recycled, so that wastewater is prevented from being generated; in addition, the preparation method is wild in reaction condition and beneficial to industrial production.

A process for producing semiconductor nanocrystal cores, core-shell, core-buffer-shell, and multiple layer systems is disclosed. The process involves a non-coordinating solvent and in situ surfactant generation.

The invention relates to a quick and efficient non-template agent hydro-thermal synthesizing method. The system can synthesize an alpha-molybdenum trioxide nanometer rod and a high-density echinoid molybdenum oxide based nanometer materials. Molybdenum peroxide acid prepared from molybdenum trioxide and aqueous hydrogen peroxide solution is used as a precursor, is produced into scattered alpha-molybdenum trioxide nanometer rod by hydro-thermal synthesis at a temperature of between 80 and 180 DEG C, and is produced into the peroxide modified molybdenum oxide hydrate by hydro-thermal synthesis at a temperature of between 65 and 75 DEG C. The hydrate is a multiscale structure; a nanometer thin slice, a micron prism and a nanometer rod-shaped structure unit are divergently assembled into a micron-size high-density echinoid structure. The hydrate is roasted to obtain high-density echinoid alpha-molybdenum trioxide. Modulation of the synthesizing condition can realize fine adjustment for appearance of the nanometer rod, the micron-size echinoid structure and the structure unit thereof. The method uses raw materials with low cost, has the advantages of simple technical process, controllable conditions and the like, and can promote research and application of the molybdenum oxide in the fields of sensors, field transmission, electrode materials and so on.

A rapid, simple and versatile metal organic framework molecule (MOF) synthesis method particularly adapted to make non-linear MOFs includes heating MOF precursors, such as a metal or metal oxide and an organic ligand, in a microwave oven for a period sufficient to achieve crystallization. Microwave-assisted MOF synthesis yields high quality MOF crystals in a reaction time ranging from about 5 seconds to about 2.5 minutes, compared to hours and days required in conventional solvothermal and hydrothermal methods. In addition, microwave assisted methods provide MOF materials with uniform crystal size and well-defined shape. Further, microwave synthesis of MOFs allows the size and shape of MOF crystals to be tailored for use in a wide range applications by manipulating reaction conditions. Secondary growth processes may also be employed to grow larger crystals using seeds obtained from microwave-assisted synthesis methods.

The invention discloses a method for fast synthesizing ZSM-5 molecular sieves. The method comprises the synthesis steps that (1) firstly, aluminum sources, silicon sources, template agents, water and alkali are uniformly mixed according to the following mol ratios: SiO2 / Al2O3 equals to 10 to 60, OH<-> / SiO2 equals to 0.1 to 0.8, R / SiO2 equals to 0 to 0.2, and H2O / SiO2 equals to 10 to 200, then, the stirring aging is carried out for 2 to 4 hours, and aged sol-gel is obtained, wherein R is template agents; (2) the aged sol-gel is baked into dry glue under the condition being 60 to 90 DEG C, and then, the dry glue is ground into powder dry glue powder; (3) the dry glue powder is placed into a reaction kettle with a polytetrafluoroethylene inner liner, water is added, and the static crystallization is carried out for 12 to 40 hours under the condition being 150 to 180 DEG C; (4) the crystallization products are taken out to be washed by water and baked, then, the temperature is raised to 450 to 650 DEG C, and the products are roasted for 4 to 6 hours to obtain the ZSM-5 molecular sieves. The method has the advantages that the supersaturation degree of the sol-gel system can be enhanced when the sol-gel is baked into dry glue so that the system fast forms crystal nucleus, and the ZSM-5 zeolite molecular sieves are fast synthesized. The method has the characteristics that the simplicity is realized, the time is saved, the cost is low, and the pollution is low.

The invention discloses a preparation method of a stannic oxide nanocrystalline loaded tin disulfide nanosheet composite nanomaterial. The method comprises the following steps that S1, a tin disulfide nanosheet is prepared, wherein L-cysteine and stannic chloride are dissolved in water and are mixed evenly, light yellow sediment is obtained after a hydrothermal reaction, rinsing, centrifugal separation and drying are carried out, and the SnS2 nanosheet is obtained; S2, a composite material is prepared, wherein stannic chloride and vitamin C are dissolved in water, the SnS2 nanosheet prepared in the S1 is dispersed in the solution, then NaHCO3 is added, even mixing is carried out, a microwave reaction is carried out under the backflow condition, cooling, rinsing, centrifugal separation and drying are carried out, and the composite nanomaterial SnO2 / SnS2 is obtained. The molar ratio of the L-cysteine to the stannic chloride added in the S1 is 6-8:1, and the molar ratio of the stannic chloride added in the S2 to the SnS2 nanosheet is 1-5:1. According to the prepared SnO2 / SnS2 composite material, SnO2 nanocrystalline is evenly dispersed and firmly loaded on the SnS2 nanosheet, the caking phenomenon of the SnO2 nanocrystalline is avoided, and the obviously-enhanced catalytic property is shown.

The invention provides a novel process for fermenting coenzyme Q10 based on online oxygen consumption rate control. Oxygen consumption rate is controlled at 30-150mmol / L*h during fermentation of coenzyme Q10 strain production, so that growth of thallus and starting and accumulation of coenzyme Q10 synthesis are promoted. Yield of coenzyme Q10 is evidently increased, unit energy consumption is lowered, and production cost is lowered greatly. The novel process is simple to control, high in operability, energy-saving and the like.

The invention provides a copper-plated carbon nanotube reinforced pantograph pan material and a preparation method thereof. The material comprises the following raw materials: Cu, CNTs, Ti3SiC2 and TiB2 in a volume ratio of (65-90):(1-20):(2-30):(1-20). The preparation method comprises the following steps of: uniformly mixing the four raw materials and glycerol, baking the mixture, loading the mixture into a steel mould, cold molding, placing the mixture in a high-temperature furnace under the protection of hydrogen, raising the temperature to 700 to 900 DEG C, preserving heat for 5 to 30 minutes, taking out the sample, cold molding again, sintering the sample at the temperature of between 800 and 900 DEG C for the second time and preserving heat for 30 to 60 minutes. The method has a simple process; the performance of the pantograph pan material can be greatly improved by the traditional equipment; and the prepared pantograph pan material has the advantage of relatively low cost.

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula;wherein X is OH, C1-C6 alkoxyl; Y and Z are independently selected from a C1-C6 alkyl, C1-C6 alkoxyl, halogen, mi-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.

A method for catalyzing and synthetizing modified stevioside by using microwave auxiliary cyclodextrin glucosyltransferase relates to the technical field of biosynthesis of organic compounds, and comprises the following steps: taking stevioside aqueous solution and starch hydrolyzates as raw materials, and synthetizing stevioside replaced by glucose residue under the combined action of microwave radiation and CGTase catalysis in a microwave reaction device. In the process condition provided by the invention, enzyme catalysis reaction can be remarkably quickened, and the phenomenon that microwave of a water system enable enzyme to be inactive under the usual condition. Through tasting, the bitter taste of the synthetic modified stevioside is greatly reduced.

A method for synthesizing a clock-tree structure may be applied to a physical design such as an integrated circuit or a printed circuit board to form a symmetrical clock-tree structure, while achieving the effects including minimizing a clock skew, having a process variation tolerance and increasing the synthesizing rate. To prevent a certain level from having too many branches and ensure that the clock-tree structure satisfies the fan-out constraint, a plurality of pseudo sinks are provided such that the result of factorizing the value of the number of the total sinks may satisfy the fan-out constraint. The levels in the clock-tree structure may have equal branch lengths by employing snaking routing, so as to achieve a symmetrical clock-tree structure design and reduce the clock skew of the clock-tree.

The invention relates to a beta-cyclodextrin functionalized silica gel microsphere chiral stationary phase, preparation, and application thereof in enantiomer separation. The preparation method comprises the following steps: introducing 3-mercapto into the surface of silica gel microspheres at first, and then adding beta-cyclodextrin derivative functional monomers and an initiator, wherein the functional monomers carry out mercapto-alkene addition reactions under the regulation of the initiator so as to obtain the surface modified beta-cyclodextrin functional monomer chiral stationary phase. The preparation of chiral stationary phase is simple, the reaction conditions are mild, and the chiral stationary phase is successfully applied to the enantiomer separation.

The invention discloses a method for preparing a hyperbranched polymer by adopting consecutive click chemical reaction, comprising the following steps: (1) adding 1 mole of dithiol compound, 0.5-10 moles of solvent, and 0.9-1.1 moles of base and 0.9-1.1 moles of compound containing alkynyl and halogen into a reactor in sequence in the presence of nitrogen to carry out sulfydryl-halogen reaction for 0.5-5 hours between minus 20 DEG C and 30 DEG C, filtering and removing generated precipitates, and carrying out decompressing evaporation to remove the solvent; (2) dissolving the products of reaction, which are obtained in the step (1), into 0.25-10 moles of solvent in the presence of nitrogen, adding 0.005-0.05 mole of photosensitive free radical initiator or thermosensitive free radical initiator, irradiating with ultraviolet light or heating at 40-90 DEG C to generate free radicals, carrying out sulfydryl-halogen reaction for 0.5-24 hours, precipitating, separating and drying to obtain the hyperbranched polymer. The method ensures that the tedious AB2 monomer synthesis and purification step is omitted, is fast and efficient and is simple in process. The prepared hyperbranched polymer containing a large number of thioether bonds and alkynyls has a wide application prospect in the fields of high-performance materials, additives and the like.

The invention relates to a rare earth hydrotalcite-like compound / polymer nanocomposite and a preparation method thereof. The method comprises the following steps: firstly prefabricating: dissolving sodium metaaluminate and sodium hydroxide in deionized water to prepare a solution A, dissolving magnesium chloride in deionized water to prepare a solution B, dissolving rare earth oxide with dilute hydrochloric acid and then putting them into the solution B to prepare a solution C, and dissolving a single ligand or a mixed ligand in sodium stearate to prepare a mixed slurry D; then under the action of strong stirring or ultrasonic wave, simultaneously adding the solution A and the solution C dropwisely in the mixed slurry D to prepare a mixed slurry E, aging, conducting pumping filtration, drying the filter cake to obtain a bright fluorescent rare earth hydrotalcite-like compound; and immersing the rare earth hydrotalcite-like compound in a polymer monomer and initiator for 24 hours, and then conducting polymerization to obtain the nanocomposite. The materials disclosed herein has excellent luminescence property of original rare earth complex, and has the advantages of good formability, strong impact resistance, light weight, low cost, easiness in film formation and the like of organic polymer materials.

The invention provides a 7 Beta-Hydroxysteroid dehydrogenase mutant, a coding sequence, a recombinant expression vector, a genetically engineered bacterium and an application thereof. Mutation is carried out on the 7Beta-hydoxy alcohol dehydrogenase from Collins aerogenes, and the reductive activity and the ratio of reducing and oxidizing activity of the obtained mutant Ca7Beta-2 are respectivelyincreased by 7.6 times and 4 times; when incubated in 100mM UDCA for 1 hour, the activity is decreased by 8.4%; at 30 DEG C and Ph 8.0, UDCA and T-UDCA are catalyzed and synthesized, and the conversion time is shortened from 24 hours to 2 hours, and the molar conversion of the substrate 7-KLCA is 100%, and the molar conversion of the substrate T-7-KLCA is 99.5% and the 7Beta-HSDH after mutation greatly reduces the production cost, improves the production efficiency, and is more suitable for industrial application.