72 results about "Methiodide" patented technology

The invention provides a new synthesis method of 9-boron bicyclo (3,3,1)-nonane (9-BBN). 1,5-cyclooctadiene and borane are taken as raw materials, a reaction is carried out in a tetrahydrofuran solvent, and the 9-boron bicyclo (3,3,1)-nonane (9-BBN) is synthesized while yield is as high as 98%. The new synthesis method comprises the following steps of adding a smashed 4A molecular sieve, tetrahydrofuran, 1,5-cyclooctadiene and zirconium tetrachloride into a reaction flask, stirring for 1 hour, dropwise adding a dimethyl sulfide complex of borane at the temperature about 0 DEG C, carrying out a reflux reaction for 4 hours after dropwise addition is completed to obtain a product, cooling the obtained product to 0 DEG C and preserving heat for 3 hours, and filtering to obtain a 9-boron bicyclo (3,3,1)-nonane (9-BBN) solid product. The new synthesis method of the 9-boron bicyclo (3,3,1)-nonane (9-BBN) has the advantages of high yield, low cost, high product purity, easy operation, is beneficial to industrialization and has a good application prospect.

The invention discloses a novel preparation method of ulipristal acetate key intermediate 3,3,20,20-double (ethylenedioxy group)-5 alpha, 17 alpha- dihydroxyl-11 bata-[4-(N,N- dimethyl amidogen)- phenyl]-19-norprogesterone-9(11)-alkene, namely 3,3- ethylenedioxy group-17 beta-cyangroup female steroid-5(10), 9(11) diene-17 alpha-alcohol is used as a raw material, through the protection of hydroxyl, the addition of Grignard reagent and cyangroup, and the protection of ketal, and the target compound is obtained finally through 1,4 addition of alpha, beta unsaturation epoxide under the catalysis of a system of cuprous halides and dimethyl sulfide. The raw materials used in the method are safe and reliable, reaction is easy to control, reaction yield and stereoselectivity are high, and the method is applicable for industrial production.

The invention belongs to the technical field of heterocyclic chemistry, particularly relates to a heterocyclic anti-tumor chemical medicine, and more particularly relates to a synthesis method of pyrimidine heterocyclic ring-containing antitumor medicine molecule AZD6738. A chiral ligand induced asymmetric oxidation method is used, chiral ligands are combined with cheap oxidizing agents (such as hydrogen peroxide) to oxidize dimethyl sulfide to prepare chiral sulfoxide, conversion of the chiral sulfoxide is efficiently achieved, a chiral sulfoxide compound 7 for the AZD6738 is prepared, and then the final product AZD6738 is prepared through an intermittent reaction. Besides, the AZD6738 is prepared by adopting a fluid chemical method, the total yield of total synthesis of the AZD6738 is remarkably improved compared with that of an intermittent reaction, and the method is suitable for industrial production.

The invention discloses a synthesis method of (R)-5-methylpyrrolidone-2-one. The synthesis method comprises following steps: step one, adding methyl levulinate, borane dimethyl sulfide, and a catalystinto a solvent, and carrying out reactions for 1 to 5 hours to obtain (R)-4-hydroxylmethyl pentanoate; step two, adding (R)-4-hydroxylmethyl pentanoate obtained in the step (1) into a reactor, introducing a nitrogen source and Raney nickel into the reactor, and carrying out catalytic reactions under a pressurized condition to obtain (R)-4-aminomethyl pentanoate; step three, adding (R)-4-aminomethyl pentanoate into a solvent, adding an alkaline catalyst, raising the temperature to 30-80 DEG C, and carrying out reactions for 0.5 to 5 hours to obtain the target product (R)-5-methylpyrrolidone-2-one; wherein the solvent in the step (1) is one or more of dichloromethane, toluene, dimethyl formamide, dimethyl sulfoxide, dichloromethane, and tetrahydrofuran. The synthesis method has the advantages of easily available and cheap raw materials, high atom utilization rate, high purity, easy purification, and high yield, and the chiral center does not need to be splitted.

The invention belongs to the technical field of sewage treatment, and particularly provides a novel deodorization process for high-standard control of sewage plant odor. A ''biotrickling-vacuum ultraviolet/catalysis'' combined process is adopted to realize efficient removal of low-concentration hydrogen sulfide, ammonia, methyl mercaptan and dimethyl sulfide in the sewage plant odor. The process is simple, low in cost and beneficial to industrial application.

The invention discloses a methyl mercaptan purification device which comprises a multi-stage condenser, an extraction tower, a coalescer, a degassing tower, a methyl mercaptan rectifying tower, a dimethyl sulfide rectifying tower, a wastewater rectifying tower and a dimethyl sulfide conversion reactor. The multistage condenser is connected with the methyl mercaptan synthesis reactor, a lower gas phase outlet is connected with the synthesis tail gas condenser, a bottom liquid phase outlet is connected with the lower part of the extraction tower, the extraction tower is connected with the coalescer and the condenser, a bottom discharge hole is connected with the middle part of the wastewater rectifying tower, the coalescer is connected with the extraction tower, the degassing tower and the methyl mercaptan rectifying tower, a top outlet of the methyl mercaptan rectifying tower is connected with the mercaptan storage tank, a bottom outlet is connected with a middle feed port of the dimethyl sulfide rectifying tower, the dimethyl sulfide rectifying tower is connected with the dimethyl sulfide conversion reactor, and a top outlet of the wastewater rectifying tower is connected with a tail gas washer. The device is reasonable in technological process, high in product methyl mercaptan purity, low in operation energy consumption and sufficient in dimethyl sulfide utilization, and is anideal methyl mercaptan purification device.

Provided herein are compositions including oxotremorine (e.g., oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods of treating a connective tissue defect in a subject with oxotremorine and 4-PPBP. In addition, provided are scaffolds and methods of making same that include multiple fibers that include Oxo-M, 4-PPBP, and optionally icariin or kartogenin.

The invention discloses a preparation method of nifuratel, which comprises the following steps: taking epoxypropyl dimethyl sulfide as an initial raw material, carrying out a synthetic reaction with carbon dioxide to obtain methylthio methyl ethylene carbonate, then carrying out a synthetic reaction with tert-butyl carbazate to obtain N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone, and finally, carrying out a reaction on the N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone and the N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone to obtain the nifuratel. And carrying out condensation reaction with 5-nitrofurfural to obtain nifuratel. The nifuratel prepared by the method is relatively high in yield and purity, the preparation process is green and pollution-free, meanwhile, the problem of carbon dioxide waste gas pollution is solved, and the defects of environmental pollution, potential safety hazards, raw material waste and the like existing in an existing nifuratel synthesis process are overcome.