209 results about "Colon rectal cancer" patented technology

The invention discloses a colon cancer marker. The colon cancer marker comprises the microorganisms of rare pediococcocci Subdoligranulum_4_3_54A2FAA and polymorph bacilli Bacteroidses. The invention further discloses a method and device for determining individual states through the colon cancer marker. Compared with healthy individuals and groups, the colon cancer marker is remarkably enriched in patient groups with colon cancer, thereby being capable of serving as a distinguishing mark for healthy groups and patient groups with colon cancer.

Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (MSI). The vaccine contains an MSI-specific frameshift peptide (FSP) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said FSP. The vaccine of the present invention is particularly useful for the prevention / treatment of colorectal cancer, endometrial cancer, gastric cancer or small bowel cancer.

The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes, which contains natural minerals and the water extracted therefrom as active ingredients. More particularly, at least one mineral selected from the group consisting of lizardite, antigorite, brucite, magnesite, dolomite, talc, clinochlore, calcite, hornblende, and phologopite, and water which is extracted from the minerals and the quality of which is suitable for the standards of drinking water, contain a significantly large amount of rare earth elements, generate a large amount of far-infrared radiation and anions to enhance and promote health, block various forms of harmful radiation such as water vein waves and electromagnetic waves, stimulate the activity of the metabolism, and have the effects of remarkably inhibiting and reducing blood glucose for type 1 and type 2 diabetes. Therefore, the mineral and the water extracted therefrom can be effectively used in developing: a pharmaceutical composition for the purpose of preventing and treating diabetes, and a healthy food composition having the same purpose; a pharmaceutical composition for the purpose of preventing and treating cancer due to having the remarkable effects of inhibiting tumors from growing or metastasizing in the case of leukemia, colorectal cancer, stomach cancer, lung cancer, and skin cancer, and a healthy food composition having the same purpose; and a pharmaceutical composition for antibacterial purposes due to having highly antibacterial effects against colon bacillus and pseudomonas aeruginosa, as well as a composition to be externally applied to the skin and a cosmetic composition having the same purpose.

The invention provides a method for establishing a colon cancer prognosis prediction model. The method comprises the following steps of: detecting the expression levels of SPARCL1 and P53 proteins in colon cancer tissues by immunohistochemistry; grading the tissue expression levels of the SPARCL1 and P53 proteins by a semi-quantitative method; and combining, analyzing and verifying the expression levels of the SPARCL1 and P53 proteins through a support vector machine, and finally establishing a judgment model. Immunohistochemistry detection, marker combination and support vector machine analysis are combined for establishing the colon cancer prediction model. The research shows that the model constructed by using the composition of the SPARCL1 and the P53 as a marker has experiment aid effect of predicting the prognosis of colon cancer patients. The model can be applied in postoperative transfer relapse risk prediction experiments of the colon cancer patients.

The invention discloses a physical examination system based on cloud computing. The physical examination system comprises a cloud microelement analyzer, a cloud weighing machine, a cloud electrocardioscanner, a cloud pulse monitor, a cloud blood pressure monitor, a cloud blood fat monitor, a cloud blood glucose monitor, a cloud vision monitor, a cloud body temperature monitor, a cloud whole-body thermal imaging monitor, a cloud transcranial Doppler monitor, a cloud bone mineral density and bone age monitor, a cloud carbon 14 breath test part, a cloud human body bio-electricity signal monitor and a cloud stethoscope. The physical examination system comprises a cloud platform, a server platform, a database, a network access device and physical examination instruments. The functions and the number of the physical examination instruments are not limited. The problems that physical examination is difficult and microelements for growth of teenagers are not balanced are solved. Serious diseases without subjective symptoms, for example, the stomach cancer, the colon cancer, the lung cancer, the breast cancer and the uterine cancer, can be found at the germination stage.

This disclosure provides methods for treating a tumor derived from a colorectal cancer exhibiting a high degree of microsatellite instability in a subject comprising administering to the subject an anti-PD-1 antibody. In some embodiments, the method further comprises administering an anti-CTLA-4 antibody. In some embodiments, the colorectal cancer is rectal cancer, colon cancer, or any combination thereof.

The invention provides a full-nutrition formula food, a specific full-nutrition formula food or a non-full-nutrition formula food for colorectal cancer patients to eat. According to the formula, the food is prepared by combining constitutive characters of the colorectal cancer patients according to the requirements of General Principles of Formula Food for Special Medical Application, and comprehending research results of current advanced physiology, medicine, nutriology, clinical application and the like of Harvard University according to the essential theory (taking homology of liver, spleen and kidney as the main principle) of traditional Chinese medicine of promoting splenic diabetes and tonifying, and balancing and recuperating. The product is prepared by taking extract essence of a plurality of traditional Chinese medicines being used as both medicines and foods, a plurality of probiotics and oligopeptides as main raw materials and taking prebiotics, carbohydrates, amino acids, a plurality of vitamins and mineral substances as auxiliary materials through mixing; and the food can be used as a single nutrition source to meet the nutritional requirements of the colorectal cancer patients and also has the effects of clearing heat and promoting diuresis, purging guts and eliminating stagnation, promoting qi to activate blood, tonifying the spleen and kidney, tonifying qi and inducing astringency, supporting the healthy energy and enhancing immunity.

Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (MSI). The vaccine contains an MSI-specific frameshift peptide (FSP) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said FSP. The vaccine of the present invention is particularly useful for the prevention / treatment of colorectal cancer, endometrial cancer, gastric cancer or small bowel cancer.

The invention relates to new functions and applications of trametes lactinea(Berk.)Pat. or extractives and trametenloic acid B. The substance trametes lactinea(Berk.)Pat has the functions of digestive gastric ulcer resistance, and nonulcerative-indigestion resistance through increasing of gastric motility. The trametes lactinea(Berk.)Pat. or the extractives and the trametenloic acid B have certain inbibitional effects on cell proliferation of gastric cancer cells, esophagus cancer cells Eca-109 and colorectal cancer cells LOVO, and has a wide range of research value and mass production and edible value in dugs for digestive system and gastric cancer resisting and the like.

The invention provides a human colon carcinoma cell line DXH-1, which is derived from primary lesion of human sigmoid colon carcinoma, and application of the human colon carcinoma cell line as a human colon carcinoma occurrence, human colon carcinoma development or human colon carcinoma transfer cell model, application of the human colon carcinoma cell line in establishing a human colon carcinoma animal model and application of the human colon carcinoma cell line in researching a human colon carcinoma occurrence mechanism and / or medicines for treating the human colon carcinoma. The human colon carcinoma cell line DXH-1 disclosed by the invention can be stably transferred for more than 50 generations, so that an appropriate material is provided for colorectal carcinoma mechanism and drug screening. In an in-vivo nude mice experiment, the human colon carcinoma cell line shows a relatively strong tumorigenesis cavity, and the cell line, transplanted subcutaneously in nude mice by 1*106 cells, is capable of promoting 100% (5 / 5) tumorigenesis after 35 days; the DXH-1 cell has certain drug resistance to colon carcinoma chemotherapeutics (5FU, such as oxaliplatin, irinotecan and the like), so that a material is provided to the researches on a colon carcinoma chemotherapeutic resistance mechanism; and the human colon carcinoma cell line DXH-1 is preserved in China Center for Type Culture Collection in Wuhan University, Wuhan, China with number of CCTCC No: C201543.

The present invention relates to a method for detecting the methylation of colorectal cancer-specific marker genes for colorectal cancer diagnosis, and more particularly to a method of detecting colorectal cancer-specific marker genes, which are methylated specifically in colorectal cancer cells, to provide information for diagnosing colorectal cancer. The use of the inventive method for detecting methylation and the inventive composition, kit and nucleic chip for diagnosing colorectal cancer makes it possible to diagnose colorectal cancer at an early transformation stage, thus enabling the early diagnosis of colorectal cancer. In addition, the inventive method enables colorectal cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods.