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Method for establishing colon cancer prognosis prediction model

A technique for predicting models and establishing methods, applied in the field of biology

Inactive Publication Date: 2011-09-14
ZHEJIANG UNIV
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Problems solved by technology

However, there is no clear report on the expression of SPARCL1 in colorectal cancer and its relationship with clinical features such as the prognosis of colorectal cancer

Method used

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  • Method for establishing colon cancer prognosis prediction model
  • Method for establishing colon cancer prognosis prediction model
  • Method for establishing colon cancer prognosis prediction model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Step 1: Detection of SPARCL1 and P53 proteins in colorectal cancer tissues

[0021] Immunohistochemical methods were used to detect the expression of P53 and SPARCL1 in the surgically resected colorectal cancer tissues of patients.

[0022] The 131 colorectal cancer tissue wax blocks were selected from surgically resected tissues of colorectal cancer patients admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine from 1999 to 2004 (23 cases of stage I, Period 43 cases, Period 56 cases, 9 cases in the first stage), and the diagnosis was confirmed by postoperative pathology. The clinicopathological data of all patients were registered in the form of follow-up form after operation, and their survival, recurrence and metastasis were followed up for more than 36 months by letter or telephone every year. Check again before the experiment started.

[0023] All tissue wax block specimens were from the tissue wax blocks archived in the Patholo...

Embodiment 2

[0033] 1. The role of SPARCL1 / P53 model in judging the prognosis of colorectal cancer patients (all stages)

[0034] figure 1 Survival curves of patients (all stages) with different discriminant results of the SPARCL1 / P53 prognostic model are shown. The Kaplan-Meier method validation showed that the SPARCL1 / P53 prediction model could divide 131 patients into two groups with great differences in survival time (P<0.001), namely good prognosis (predicted value = 0) and bad prognosis (predicted value = 0). 1), the estimated median survival time of the patients in the good prognosis group was 91.676 months, and the estimated median survival time of the patients in the bad prognosis group was 41.928 months.

[0035] . Predictive effect of SPARCL1 / P53 model on postoperative recurrence and metastasis of colorectal cancer patients

[0036] Among these patients, the incidence of postoperative recurrence and metastasis in the good prognosis group (predicted value = 0) was 22.34%, whi...

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Abstract

The invention provides a method for establishing a colon cancer prognosis prediction model. The method comprises the following steps of: detecting the expression levels of SPARCL1 and P53 proteins in colon cancer tissues by immunohistochemistry; grading the tissue expression levels of the SPARCL1 and P53 proteins by a semi-quantitative method; and combining, analyzing and verifying the expression levels of the SPARCL1 and P53 proteins through a support vector machine, and finally establishing a judgment model. Immunohistochemistry detection, marker combination and support vector machine analysis are combined for establishing the colon cancer prediction model. The research shows that the model constructed by using the composition of the SPARCL1 and the P53 as a marker has experiment aid effect of predicting the prognosis of colon cancer patients. The model can be applied in postoperative transfer relapse risk prediction experiments of the colon cancer patients.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for establishing a colorectal cancer prognosis prediction model using SPARCL1 and P53 as markers. Background technique [0002] Colorectal cancer is a common malignant tumor, and its morbidity and mortality rank among the top in the spectrum of malignant tumors in my country and western developed countries. From 2000 to 2004, the incidence rate of colorectal cancer ranked third among all malignant tumors in the United States, and the mortality rate also ranked third. In my country, with the improvement of living standards and changes in eating habits, the incidence of colorectal cancer is also increasing day by day, and has jumped to No. 4. There are 400,000 new cases of colorectal cancer every year, with an increase rate of nearly 5%. Many of them It is a middle-aged person aged 30-40. Compared with the 1970s in the 1990s, the incidence of colorectal cancer in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
Inventor 虞舒静余捷凯郑树葛维挺胡涵光
Owner ZHEJIANG UNIV
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