The invention discloses a three-dimensional bionic self-healing hydrogel
fiber scaffold composition and a preparation method and application thereof. The
scaffold composition is composed of a
biocompatible material, a nano material and a small molecular compound. By using electrostatic
spinning, self-crosslinking and mold forming methods, a
mixed solution of the
biocompatible material, the nano material and the small molecular compound is mixed with an
organic solvent in proportion to form a
scaffold with biomedical application, particularly a layer-by-layer self-crosslinking three-dimensionalscaffold for
muscle regeneration. The biomedical hydrogel
fiber scaffold disclosed by the invention can provide
cell adhesion sites and signals for inducing
cell proliferation and differentiation, has excellent
mechanical strength and biodegradability, and has the characteristics of easiness in preparation, low cost, good compatibility and wide application. Rat in-vivo experiments show that: thethree-dimensional bionic hydrogel
fiber scaffold can induce differentiation of
muscle fibers, reduce
oxidative damage to cells and tissues and promote regeneration of muscles and new vessels, and hasgood clinical application conversion value.