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Three-dimensional bionic self-healing hydrogel fiber scaffold composition and preparation method and application thereof

A technology of hydrogel fibers and fiber scaffolds, which is applied in the field of biomedicine, can solve the problems that the scaffolds do not have the strength of muscle kinematics and the synthesis process is complicated, and achieve good clinical application prospects, good biocompatibility, and increase the speed of tissue regeneration Effect

Inactive Publication Date: 2020-04-28
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method disclosed in these patents is to directly mix graphene or modified graphene with hydrogel. The prepared scaffold does not have the mechanical strength required for muscle movement, and the synthesis process is complicated.

Method used

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  • Three-dimensional bionic self-healing hydrogel fiber scaffold composition and preparation method and application thereof
  • Three-dimensional bionic self-healing hydrogel fiber scaffold composition and preparation method and application thereof
  • Three-dimensional bionic self-healing hydrogel fiber scaffold composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A three-dimensional bionic self-healing hydrogel fiber scaffold, the preparation method of which is as follows:

[0054] Take the biocompatible material with a weight ratio of 99%, and the nanomaterial with a weight ratio of 1%, which is a composition for a fiber scaffold; the biocompatible material is preferably polycaprolactone, and the nanomaterial is preferably single-layer graphite alkene.

[0055] Polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then graphene is added and mixed thoroughly to obtain a composition solution capable of forming a fiber film. The solvent is preferably dichloromethane.

[0056] After the above-mentioned graphene composition solution is debubbled by an ultrasonic machine, inject it into the injector, output it at a flow rate of 0.1ml / min, and spray it onto a receiving plate with a length of 30cm and a width of 20cm. The negative voltage is -4KV, and the positive voltage is It is 12KV, and the receivi...

Embodiment 2

[0063] A three-dimensional bionic hydrogel fiber scaffold, the preparation method of which is as follows:

[0064] Take the biocompatible material with a weight ratio of 99%, and the small molecular compound with a weight ratio of 1%, which is a fiber scaffold composition; the biocompatible material is preferably polycaprolactone, and the nanomaterial is preferably melatonin .

[0065] Polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then melatonin is added and mixed well to obtain a composition solution capable of forming a fibrous film. The solvent is preferably dichloromethane.

[0066] After removing bubbles from the above-mentioned melatonin composition solution with an ultrasonic machine, inject it into the injection device, output it at a flow rate of 0.1ml / min, and spray it onto a receiving plate with a length of 30cm and a width of 20cm, negative voltage -4KV, positive voltage It is 12KV, and the receiving distance is 25cm; the e...

Embodiment 3

[0073] A three-dimensional bionic hydrogel fiber scaffold, the preparation method of which is as follows:

[0074] The biocompatible material with a weight ratio of 98%, the nanometer material with a weight ratio of 1%, and the small molecular compound with a weight ratio of 1% are the fiber scaffold composition; the biocompatible material is preferably polycaprolactone, The nanomaterial is preferably single-layer graphene, and the small molecular compound is melatonin.

[0075] Polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then graphene and melatonin are added and mixed thoroughly to obtain a composition solution capable of forming a fibrous film. The solvent is preferably dichloromethane.

[0076] After removing bubbles from the above-mentioned graphene and melatonin composition solution with an ultrasonic machine, inject it into the injector, output it at a flow rate of 0.1ml / min, and spray it onto a receiving plate with a length of ...

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Abstract

The invention discloses a three-dimensional bionic self-healing hydrogel fiber scaffold composition and a preparation method and application thereof. The scaffold composition is composed of a biocompatible material, a nano material and a small molecular compound. By using electrostatic spinning, self-crosslinking and mold forming methods, a mixed solution of the biocompatible material, the nano material and the small molecular compound is mixed with an organic solvent in proportion to form a scaffold with biomedical application, particularly a layer-by-layer self-crosslinking three-dimensionalscaffold for muscle regeneration. The biomedical hydrogel fiber scaffold disclosed by the invention can provide cell adhesion sites and signals for inducing cell proliferation and differentiation, has excellent mechanical strength and biodegradability, and has the characteristics of easiness in preparation, low cost, good compatibility and wide application. Rat in-vivo experiments show that: thethree-dimensional bionic hydrogel fiber scaffold can induce differentiation of muscle fibers, reduce oxidative damage to cells and tissues and promote regeneration of muscles and new vessels, and hasgood clinical application conversion value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a three-dimensional bionic self-healing hydrogel fiber scaffold composition and a preparation method and application thereof. Background technique [0002] Muscle damage is a series of abnormal changes in cells or intercellular matrix caused by muscle cells and tissues being stimulated by intolerable harmful factors. Mild tissue degeneration, severe tissue necrosis can be induced. The patients with muscle injuries are mainly middle-aged and elderly people, and tend to be younger. Due to its high incidence, slow healing and long duration, it seriously affects the quality of life of patients. There are many reasons for muscle damage, such as chemical injury, or strenuous exercise and large-scale trauma accidents, side effects of surgery and drugs, etc. At present, the methods for treating muscle injuries include autologous tissue transplantation, prosthetic impla...

Claims

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Application Information

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IPC IPC(8): A61L27/08A61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L27/58C08J3/075C08L67/04C08L5/08C08L89/00C08K3/04
CPCA61L27/08A61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L27/58A61L2300/204A61L2300/412A61L2430/30C08J3/075C08J2305/08C08J2367/04C08J2489/00C08K2201/011C08K3/042C08L67/04C08L5/08
Inventor 袁伟恩徐阳陈璇吴子薇崔钟予白燕·色列克
Owner SHANGHAI JIAO TONG UNIV
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