Chitosan hydrogel dressing and preparation method thereof

Abstract

The invention relates to chitosan hydrogel dressing and a preparation method thereof, and belongs to the technical field of hydrogel dressing in a biological medical material. The chitosan hydrogel dressing is prepared from 1 to 8 parts of chitosan or a derivative thereof, 0.1 to 3 parts of gamma-polyglutamic acid or salt thereof and 6 to 10 parts of oxidized hyaluronic acid or salt thereof. The chitosan hydrogel dressing provided by the invention can be prepared by taking water as a solvent and the biological cross-linking agent oxidized hyaluronic acid as a cross-linking agent through Schiffbase reaction, without the need of introducing other cross-linking agents and initiators; the cost and the biological toxicity of a gel product are extremely reduced, and the safety of clinical application of a gel material is ensured. The dressing has excellent biocompatibility and water absorbability; the cross-linking agents and the initiators are not added, so that the chitosan hydrogel dressing is safe and has no toxin, and a production process and a degraded product of the dressing do not pollute the environment.

Description

technical field [0001] The invention relates to a hydrogel dressing and a preparation method thereof. More specifically, the invention relates to a chitosan hydrogel dressing and a preparation method thereof, belonging to the technical field of hydrogel dressings in biomedical materials. Background technique [0002] Dressings are a class of materials used to cover sores, wounds or other damages. They are used to isolate, protect, and treat sores or wounds. Dressings can be divided into various types according to their materials and functions. Hydrogel dressing is a kind of dressing with high water content, non-stick wound, and easy to remove. The hydrogel in the dressing is a high molecular polymer with a three-dimensional network cross-linked structure, which can exist stably in water for a long time. It is insoluble and has excellent physical and chemical properties, such as softness, hydrophilicity and biocompatibility. Due to the large number of mesh structures in the p...

AI Technical Summary

Problems solved by technology

[0005] In the above-mentioned prior art scheme, there is the addition of a crosslinking agent, and some crosslinking will occur after high-energy ray irradiation, but sodium carboxymethylcellulose, glucomannan, water-soluble chitosan, polyglutamic acid, After hyaluronic acid is irradiated by high-energy rays, it will be degraded sharply, the molecular weight will become smaller, and cross-linking and degradation will occur at the same time, which has great disadvantages for the formation of gels.