53 results about "Eleutheroside" patented technology

Described herein are caffeine-free compositions that provide a sense of energy and well-being. In one aspect, the compositions include a blend of natural herbs or herbal extracts such as at least one Schizandra, at least one Rhodiola, an eleutheroside, at least one Cordyceps, at least one Lycium (genus of goji), and at least one Ribes to revitalize one's state of well being. Additional herbs, herbal extracts, sweeteners, vitamins, minerals, and additional nutrients may be added to the composition for additional benefits and improved taste. In some embodiments, the composition is provided as a beverage, e.g. a carbonated beverage.

Vaccines containing adjuvant comprising eleutherosides and related compounds are shown to be useful for the prevention of viral infections, bacterial infections and parasitic infections. The adjuvant compounds have been shown to modulate the expression of a wide variety or proteins involved in the immune response and inflammatory response. Exemplary eleutherosides and related compounds include eleutheroside A, eleutheroside B, eleutheroside C, eleutheroside D, eleutheroside E, eleutheroside F, and eleutheroside G, coniferylaldehyde, caffeic acid ethyl ester, chlorogenic acid, sinapinalcohol, isofraxidin, syringaresinol and 6,8-dimethoxy-7-hydroxycoumarin.

The invention provides a natural drug composition for curing rheumatism bone diseases and a preparation method thereof. The composition comprises the following components in parts by weight: 400 to 500 parts of garden balsam stem extract, 200 to 400 parts of sulforaphane, 900 to 1000 parts of glucosamine; 400 to 500 parts of flemingia philippinensis extract, 300 to 400 parts of eleutheroside, 200 to 300 parts of rhizoma smilacis glabrae extract, 400 to 500 parts of rhizoma drynariae extract, 400 to 500 parts of icariin, 1300 to 1400 parts of black ant extract, 500 to 600 parts of tongkat ali extract, 150 to 250 parts of carapax trionycis powder, 300 to 400 parts of chondroitin sulfate, 0 to 300 parts of caulis spatholobi extract, 0 to 400 parts of radix clematidis extract, 0 to 300 parts of collagen protein, 0 to 270 parts of common clubmoss herb extract and 0 to 200 parts of uncaria tomentosa extract. The natural drug composition can serve as an oral drug to be absorbed through stomach, and has no toxic or side effects.

The invention provides a differential medium for obtaining oligodendrocyte progenitor cells and proliferation thereof by processing mesenchymal stem cells through eleutheroside. The differential medium comprises a liquid basal medium, and also comprises 1-100ug / mL eleutheroside, 1 to 20 percent of fetal calf serum, 5 to 300ng / mL human epidermal growth factor (EGF) and 5 to 300ng / mL basic fibroblast growth factor (bFGF) based on the volume of the liquid basal medium. The invention also provides a method for preparing an eleutheroside processing kit by using the differential medium, and also provides a medicinal composition comprising the oligodendrocyte progenitor cells prepared by the method and used for treating nerve system disease. By using the differential medium, the method has the advantages that: the mesenchymal stem cells can be efficiently differentiated and the oligodendrocyte progenitor cells are obtained. The medicinal composition for treating diseases such as traumatic spinal cord injury, multiple sclerosis and the like can repair injured nerve cells in vivo and eliminate neurologic disorder.

The invention provides a poultry feed, namely a poultry feed including eleutheroside and composite probiotic. The poultry feed capable of reducing subcutaneous and viscera fat deposition of the poultry feed, and is characterized by comprising the eleutheroside, the composite probiotic, honey and a basic feed, wherein the eleutheroside to a total weight of the poultry feed is 0.1-4.0%, the composite probiotic to the total weight of the poultry feed is 1.0-6.0%, the honey to the total weight of the poultry feed is 0.5-6.0%, and the basic feed to the total weight of the poultry feed is 84.0-98.4%. The composite probiotic comprises the following components in mass ratio: 30-55% of Bacillus licheniformis, 35-45% of bifidobacterium and 35-45% of lactic acid bacillus, the number of viable count of the Bacillus licheniformis is not less than 200,000,000 / g, and the spore forming rate is larger than 85%; the viable count of the bifidobacterium is not less than 107 / g, and the spore forming rate is larger than 87%; and the viable count of the lactic acid bacillus is not less than 107 / g. The poultry feed including the eleutheroside and the composite probiotic, disclosed by the invention, fully exerts effects of the eleutheroside and the composite probiotic, and after the eleutheroside and the composite probiotic are added to the poultry feed, the subcutaneous and viscera fat deposition can be remarkably reduced, the disease resistance rate is strengthened, the meat quality is modified, and economic benefit and social benefit are remarkable.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an acanthopanax composition, a preparation containing the acanthopanax composition and a detection method thereof. The acanthopanax composition contains eleutheroside of 31-167 mg / g, total flavonoids of 11-199 mg / g, total sugar of 224-736 mg / g and total inorganic salt of 20-173 mg / g. The detection method includes detection of (1) total glycosides, (2) the total sugar, (3) the total flavonoids, (4) total inorganic cations, (5) total inorganic anions and (6) total solids. The acanthopanax composition and the injection provided have more balanced components and obvious effect in lowering blood sugar, blood fat and the like, the efficacy of the acanthopanax composition is better than that of the prior art and the toxicity is relatively smaller and relatively safer.

The invention relates to a composition having an anti-depression effect. The composition is composed of eleutheroside and salidroside in a weight ratio of (1-10): (1-10). The invention also discloses a preparation method of the composition. The composition can be applied to preparing anti-depression medicines.

The invention discloses a cistanche extract composition with the effect of obviously relieving the physical fatigue and a preparation method thereof. A traditional Chinese medicine extract is prepared from 90 to 150 parts of cistanche tubulosa wight extracts, 100 to 170 parts of eleutherococcus senticosus extracts and 80 to 110 parts of epimedium brevicornum extracts, wherein the content of phenylethanoid glycosides in the cistanche tubulosa wight extracts is greater than 40.0 percent; the content of eleutheroside B1 and C in the eleutherococcus senticosus extracts is greater than 0.8 percent; the icariin in the epimedium brevicornum extracts is greater than 8.0 percent. Functional experiments prove that the physical fatigue relieving efficiency of the composition prepared by compounding the eleutherococcus senticosus extracts with the eleutheroside B1 and C reaching the standard, the cistanche tubulosa wight extracts and the epimedium brevicornum extracts can be obviously improved, and the action is even better than that of the eleutheroside B and E; the mouse loading swimming time can be obviously prolonged; the mouse hepatic glycogen storage quantity is increased; the serum urea level after mouse movement is reduced; the mouse fatigue is relieved; the effect is better than that of the single use of the cistanche tubulosa wight extracts.

The invention relates to a medical usage of eleutheroside and the aglycone thereof, in particular to the application of the glycoside with the following formula I or the aglycone with the formula II in the preparation of the drugs for the diseases caused by inflammatory mediators, wherein, the inflammatory mediators are HMGB1, TNF-Alpha or IL-1 particularly. The glycoside of R1 R2 R3 R4 formula Iis: H COOH H-Beta-D-glc6-Beta-D-glc4-Alpha-L-rha, and the aglycone of formula II is: H COOH H H.

The invention belongs to the field of traditional Chinese drug extracting, and relates to a method for extracting eleutheroside. The method comprises the following steps: (1) dissolving acanthopanax aqueous extract through methanol, then carrying out a ultrasonic process to uniformly dissolve the acanthopanax aqueous extract, followed by filtering through a micropore film to obtain filtrate to provide a spare use; (2) adopting a macroporous resin column chromatography for separating the filtrate prepared from the step (1), wherein a stationary phase is a HPD-450 macroporous adsorptive resin, a elution solvent 1 is a ethanol water solution having a volume percentage less than 30%, a elution solvent 2 is a ethanol water solution having a volume percentage more than 30%; sequentially adopting 3-6 times of column volume of the elution solvent 1 and the elution solvent 2 to carrying out elutions, and collecting eluent corresponding to the elution solvent 2. With the present invention, impurities are successfully separated from the eleutheroside, a content of the final extracted eleutheroside is high, and industrial cost for preparing the eleutheroside is low.

The invention discloses a synthetic method of a deep eutectic solvent and a method for extracting and purifying eleutheroside B by using the deep eutectic solvent. The synthetic method comprises the following steps: mixing choline chloride, L-proline and water; stirring the mixed components at a constant temperature to synthesize a deep-eutectic solvent, drying the acanthopanax, grinding the acanthopanax into powder, and sieving the powder with a 60-80-mesh sieve; and putting acanthopanax powder into an extraction tank, adding a deep-eutectic solvent, and then stirring at constant temperature to obtain an extracting solution of eleutheroside B; The method for extracting the eleutheroside B in the acanthopanax by using the eutectic solvent and adopting a constant-temperature heating and stirring method is efficient, green, safe and low in cost, and compared with a 70% ethanol solvent, the method has relatively high extraction efficiency and relatively simple and convenient purification process on the eleutheroside B in the acanthopanax.

The invention belongs to the field of health foods, and discloses nutritious fine dried ganoderma-lucidum noodles and a preparation method thereof. The nutritious fine dried ganoderma-lucidum noodlesare prepared from the following raw materials in parts by weight: 70-80 parts of wheat flour, 10-15 parts of soybean powder, 5-8 parts of skimmed milk powder, 4-6 parts of walnut powder, 8-10 parts ofganoderma lucidum liquid, 1-3 parts of red-rooted salvia root extract, 0.5-1 part of eleutheroside, 0.5-1 part of gastrodine, 4-6 parts of eggs, 0.2-0.4 part of CMC , 1-2 parts of edible salt, and 0.1-0.3 part of edible alkali. The soybean powder, the walnut powder and the skimmed milk powder are used as auxiliary materials of the nutritious fine dried ganoderma-lucidum noodles; and functional ingredients, including the gastrodine, the eleutheroside, the red-rooted salvia root extract, the ganoderma lucidum liquid and the like, are added so that the nutritious fine dried ganoderma-lucidum noodles have improved nutritional values, and are capable of regulating content of brain neurotransmitter so as to delay epileptic seizures and reduce degree of attack by blocking calcium influx. And thus, the nutritious fine dried ganoderma-lucidum noodles have certain effects on resisting epilepsy.

The invention belongs to the technical field of traditional Chinese medicine preparations, and specifically discloses a preparation with the effect of reducing blood glucose and blood fat and a preparation method of the preparation. The preparation mainly comprises the following raw materials in parts by weight: 3 to 10 parts of hawthorn, 5 to 15 parts of Chinese yam, 3 to 5 parts of fruit of Chinese wolfberry, 5 to 15 parts of sweet Chinese catalpa grass, 5 to 20 parts of root of kudzu vine, 10 to 20 parts of gynostemma pentaphylla, 0.1 to 0.5 part of corn stigma, 1 to 3 parts of vernoniaamygdalina del leaves, 2 to 6 parts of butterflybush flower, 0.001 to 0.005 part of eleutheroside, 0.03 to 0.07 part of soy isoflavone, 1 to 5 parts of oxidized konjac glucomannan and 0.05 to 0.5 part offermented soya bean fibrinolytic enzyme. According to the traditional Chinese medicine preparation provided by the invention, the blood viscosity can be effectively improved, the blood glucose and blood fat are reduced, and the metabolic activity of fat is strengthened; partial raw materials come from food, the preparation is safe without side effect, and the preparation is convenient to take andgood in taste; and the preparation can be mixed with flour and buckwheat powder in a certain proportion, so that a health food capable of reducing blood glucose and blood fat is prepared.

The invention discloses an anti-stress compound preparation, which consists of 30 weight parts of Chinese medicinal composition and 0.65 weight part of nutrient composition, wherein the Chinese medicinal composition comprises the following components in part by weight: 5 to 40 parts of 0.8 percent eleutheroside, 5 to 40 parts of 2 percent salisorosides rosavin, 3 to 20 parts of spina date seed, 10 to 70 parts of grassleaf sweelflag rhizome, 5 to 50 parts of tribulus terrestris L. and 5 to 40 parts of astragalus; and the nutrient composition comprises the following components in part by weight: 100 to 300 parts of tyrosine, 3 to 20 parts of vitamin C, 40 to 100 parts of vitamin B2, 100 to 220 parts of vitamin B1, 40 to 100 parts of vitamin B6, 100 to 220 parts of vitamin PP, 2 to 12 parts of folic acid, 40 to 120 parts of ferrous lactate and 200 to 800 vitamin E powder containing 30 percent of VE. Capsules of the invention are proved by clinical application to have the effects of supporting right, securing the root and enhancing the immunity of organisms, are applied to people with relatively higher life stress and work stress in the modern society, and can enhance the endurance of the organisms, reduce the stress-resisting stress levels of the organisms and improve the anti-stress capability of the organisms.

The invention relates to a preparation method of acanthopanax tea, which solves the problems that an existing preparation process of the acanthopanax tea is rough, the quality of the tea is not outstanding and the effect of the tea is not obvious in clinical utilization. The method comprises the following steps of: 1, picking fresh stems and leaves of acanthopanax or acanthopanax senticosus as raw materials, and washing and drying the raw materials; 2, roasting the raw materials in a tea roasting machine to obtain roasted stems and leaves; 3, rolling the roasted stems and leaves in a tea rolling machine, drying and sterilizing the rolled stems and leaves, and improving the aroma of the rolled stems and leaves; 4, crushing the stems and leaves into powder particles in a crushing machine, and packaging the crushed stems and leaves to obtain the acanthopanax tea. According to the preparation method of the acanthopanax tea disclosed by the invention, a preparation process of the acanthopanax tea is scientific and reasonable, and general flavone and eleutheroside in the natural acanthopanax are reserved to the greatest extent, wherein the general flavone is 90%-95% of a labeled amount by taking anhydrous rutin to calculate, and the content of the eleutheroside is 3%; and the acanthopanax tea has the effects of mediating brain nerves of a human body, accelerating sleeping, preventing diseases caused by nerve stress, resisting fatigues, recovering capability and enhancing human body immunity.

The invention relates to a method for culturing Acanthopanax senticosus tetraploid. An aqueous solution of 0.01% colchicine and 0.3% dimethyl sulfoxide is used as an inducer to induce Acanthopanax senticosus seeds to obtain Acanthopanax senticosus tetraploid plant. The inducing method has Acanthopanax senticosus survival rate of 91.3%, and inductivity of 84.6%. The root, stem, leaf, plant height and the like of tetraploid Acanthopanax senticosus are all significantly better than original diploid Acanthopanax senticosus, so as to greatly increase the yield of medicinal material, and the eleutheroside content in tetraploid Acanthopanax senticosus is increased by 20%, compared that in the original diploid Acanthopanax senticosus. The method performs genetic improvement on Acanthopanax senticosus, and for the culture method of tetraploid Acanthopanax senticosus, colchicine and dimethyl sulfoxide are used to mutagenize the seeds. The method is simple and practicable, has high induction rate, and can be used for polyploidy seed selection, so that polyploidy breeding becomes an important method for genetic improvement and new variety breeding of Acanthopanax senticosus.

Ultrasonic and microwave dual-assistance is applied to purification of eleutheroside, so that the adsorption selectivity for eleutheroside is good, adsorption and desorption are fast, and the adsorption capacity is larger. Extraction is convenient and fast, the production cost is low, the separation effect is obvious, the extraction purity is high, 90% or higher of eleutheroside can be obtained, and the defects of relatively low conventional extraction rate and low extraction purity are overcome. Polyamide resin adsorption chromatography with stable physical and chemical properties, larger surface area, higher exchange speed, high mechanical strength, high anti-pollution capacity and good thermal stability is adopted, selectivity to organic matter is better, influence of existence of inorganic salts and strong ionic low molecular compounds is avoided, and morin can be adsorbed selectively from the solution by physical adsorption. The method has the advantages of fast adsorption, fast desorption and larger adsorption capacity.

The invention discloses a topical plaster for treating rheumatoid arthritis. The topical plaster comprises, by mass, 22-25 parts of raw materials, 0.01-0.015 part of hirudin, 0.01-0.015 part of eleutheroside, 0.015-0.020 part of tongkat ali extract, 1-2 parts of tung oil, 0.8-1.2 parts of transdermal agents, 1.5-2.5 parts of rosin and 0.8-1.2 parts of beeswax, wherein the raw materials include typhonium giganteum, angelica sinensis, raw radix aconiti, ground beetles, rhizoma arisaematis, tripterygium wilfordii, semen strychni, dysosma versipellis rhizomes, podophyllum emodi, Philippine flemingia roots, phryma leptostachya, dysosma majorensis, rhizoma crynariae extract, myrrh, dchisandra propingua, polyrhachis dives, radix angelicae pubescentis, dragon's blood and fruit shells of tung trees. The invention further discloses a preparation method of the topical plaster for treating the rheumatoid arthritis. The topical plaster has the advantages of quick action, good curative effect and noside effect.

The invention belongs to the field of extraction and application of plant components, and particularly relates to oral liquid containing radix acanthopanacis senticosi and a method for extracting eleutherosides from the radix acanthopanacis senticosi. According to the invention, the eleutherosides in the radix acanthopanacis senticosi is extracted by a high-pressure extraction process; the eleutherosides are further purified by a polyamide resin and macroporous adsorption resin separation and purification process. The oral liquid containing radix acanthopanacis senticosi provided by the invention only contains drug components with enhanced anti-fatigue ability, has a high content of effective active components and fewer impurities, avoids potential sensitization risks in traditional Chinese medicine drink and burdens and damages caused by complicated drug components to liver and kidney of a user, and can be used for preparing more targeted efficient low-toxic healthcare drink; and theanti-fatigue ability of the user is more comprehensively enhanced by compatibility of various drug polysaccharides in the healthcare drink.

The invention discloses a compound preparation for treating vertebra osteomyelitis and a preparation method of the compound preparation. The compound preparation consists of the following ingredients: amikacin, diacerein, onychin, eleutheroside, paracetamol glucoside, active protein peptide, chitosan, trace elements, vitamin D, methyl salicylate, arbutin, algae polysaccharide, tramadol hydrochloride, radix dipsaci alkali and gypenoside. The compound preparation for treating the vertebra osteomyelitis disclosed by the invention has functions of relieving pain, resisting inflammation and killing bacteria, and the compound preparation is capable of promoting blood circulation, promoting development of bones and strengthening tendons and bones; moreover, the compound preparation is capable of relieving apoptosis, enhancing resistance of organs and improving human metabolism; and clinical application verifies that the compound preparation is significant in curative effect on the vertebra osteomyelitis, and the compound preparation is safe and low in side effects.

The invention discloses a composition taking hederacolchiside A1 as a main component. The composition is characterized by mainly comprising the hederacolchiside A1, eleutheroside K, leonloside B, Saponin Pe, raddeanin R22 and raddeanin R23; the total mass content of the hederacolchiside A1, the eleutheroside K, the leontoside B, the Saponin Pe, the raddeanin R22 and the raddeanin R23 in the composition ranges from 60.00% to 100%. The composition can be used for preventing and treating rheumatic arthritis and inflammatory pain.

The invention belongs to the field of healthcare foods, and discloses glossy ganoderma nutritive fine dried noodles and a preparation method thereof. The fine dried noodles include, by weight, 70-80 parts of wheat flour, 10-15 parts of soybean powder, 5-8 parts of skim milk powder, 4-6 parts of walnut powder, 8-10 parts of glossy ganoderma liquid, 1-3 parts of danshen root extract liquid, 0.5-1 part of eleutheroside, 0.5-1 part of gastrodine, 4-6 parts of eggs, 0.2-0.4 part of CMC, 1-2 parts of table salt, and 0.1-0.3 part of sodium carbonate. The soybean powder, the walnut powder and the skimmilk powder are adopted as auxiliary materials and the gastrodine, the eleutheroside, the danshen root extract liquid, the glossy ganoderma liquid and other functional components are added, and therefore, nutrition value of the noodles is improved, and through regulation of the brain neurotransmitter content, outbreak of epilepsy is delayed by calcium influx blocking and the degree of outbreak isreduced, so that the fine dried noodles have a certain anti-epileptic function.

The invention provides a Chinese patent medicine for treating gout. The compound preparation capable of reducing concentration of serum uric acid and treating gout is characterized by being prepared from the following components in percentage by weight: 30 percent of rhizoma smilacis glabrae, 15 percent of yam rhizome, 10 percent of benzbromarone, 10 percent of eleutheroside, 5 percent of picroside, 10 percent of triptolide, 10 percent of croceic acid and 10 percent of cordycepic acid, and the eight medicinal materials are mixed according to the proportion to prepare a tablet. The tablet or pill is orally taken for 0.5-1.0g each time, and is taken three times a day with warm boiled water after meals, and is taken continuously for 2-3 weeks.

The invention discloses health care medical wine and a preparation method thereof. The health care medical wine is technically characterized by comprising, by weight, 4-5 parts of amur grape vines, 2-3 parts of multiprickle acanthopanax fruits and 1-1.2 parts of honey and rock candy flavoring agents. The preparation method includes an acid discharge process. After long-time fermentation, the medical wine sufficiently extracts beneficial components easily absorbed by human bodies, wherein the beneficial components include various fructose, glucoside, coumarin glycoside, tartaric acid, multiprickle acanthopanax general flavone, eleutheroside and the like. Compared with common fruit wine, the health care function of the health care medical wine is improved by several times and even dozens oftimes, and the health care medical wine has the functions of strengthening body resistance, nourishing blood, soothing nerves and nourishing and strengthening bodies for symptoms such as insomnia, amnesia, palpitation, weakness, hypertension, coronary heart diseases, cerebral thrombosis and endocrine dyscrasia. The health care medical wine further has the advantages of better colors, good taste, preservation resistance and the like. The acid discharge sterilization process is added, and the preparation method solves the technical problem that health care medical wine is easy to mildew and poorin taste and contains toxic substances in the prior art.

The invention belongs to the field of pharmaceutical preparations, and in particular relates to an Acanthopanax senticosus composition, a preparation containing the same and a detection method thereof. The Acanthopanax senticosus composition contains 31-167mg / g total glycosides, 11-199mg / g total flavonoids, 224-736mg / g total sugars and 20-173mg / g total inorganic salts. The detection method includes detection of (1) total glycosides, (2) total sugars, (3) total flavonoids, (4) total inorganic cations, (5) total inorganic anions, and (6) total solids. The components in the Acanthopanax senticosus composition and injection provided by the invention are more balanced, have obvious effects in lowering blood sugar and blood fat, and have better drug efficacy than the prior art; relatively less toxicity and safer.

The invention discloses a method for preparing eleutheroside. The method comprises the following steps: (1) crushing acanthopanax root into coarse particles of 12-20 meshes, extracting 1-3 times with water or less than 95 percent ethanol, for 1-2 hours each time, combining the extracts, concentrating at reduced pressure until the relative density is 1.10-1.15 at 55 DEG C to obtain a concentrate, and investigating with 3 index components in the acanthopanax root; (2) performing resin column chromatography on the concentrate: washing with water, and eluting with 8-10BV of 30-70 percent ethanol or methanol as eluent, combining the eluents, concentrating at reduced pressure until the eluents are dried, and crushing, wherein the resin column is HP-20, D-101, AB-8 or NKA-9. The product prepared by the method for preparing eleutheroside is high in active component content, high in purity and low in cost.

The invention discloses a method for extracting total eleutheroside. Microwave extraction is adopted in the method, and the microwave extraction time is 8-12 minutes; the extraction quantity of the total eleutheroside can be improved by adopting the method for extracting the total eleutheroside, and is generally 20-55wt% in the prior art but 50-80wt% in the method; the consumption of a solvent and the production of wastes are low, so the method meets the requirements of green chemistry and environmental protection; and the purity of the extract obtained by adopting the method is high.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an acanthopanax senticosus extract composition and an extraction method thereof, and a preparation method of an acanthopanax senticosus injection. The acanthopanax senticosus extract composition comprises the following components of fructose, glucose, sucrose, maltose, chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, eleutheroside B and eleutheroside E. The preparation method of the acanthopanax senticosus composition comprises the steps of performing water extraction and alcohol precipitation on acanthopanax senticosus medicinal materials, adsorbing the processed medicinal materials with macroporous adsorption resin and eluting with ethanol with a certain concentration. The acanthopanax senticosus composition is used for treating cardiovascular system diseases.