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Method for producing isoforaxidin, eleutheroside and eleutheran from Radix Acanthopanacis senticosi

A technology of Acanthopanax polysaccharides and isoxazinidine, which is applied in the production of bulk chemicals, chemical instruments and methods, sugar derivatives, etc., can solve the problem of only one product, achieve high production efficiency and simple production process , The method is accurate and reliable

Inactive Publication Date: 2003-10-22
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet above-mentioned production technique all is to adopt con

Method used

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Effect test

Embodiment 1

[0019] The rhizomes of Acanthopanax senticosus were crushed to a particle size of about 70 mesh, and 180 grams were weighed. The drying temperature was 60°C and the drying time was 6 hours. After drying, put it into the extraction kettle, the extraction conditions are: extraction pressure is 27MPa, temperature is 40℃; separation conditions are: first-stage separation kettle pressure is 6MPa, temperature is 50°C, second-stage separation kettle 14 pressure is 5MPa, temperature is 45°C. 65% ethanol is used as an entrainer. After 4 hours of dynamic operation. 735ml of isotriazine extract was obtained from the primary separation kettle and the secondary separation kettle, and the extract was concentrated and vacuum dried to obtain isotriazine. The relative content of isotriazine is 64.34%, and the yield is 0.5381‰ (weight of solid product / dry weight of raw material).

[0020] Take out the waste residue in the supercritical extraction kettle, extract with 6 times the volume of 40% ethan...

Embodiment 2

[0023] The rhizome of Acanthopanax senticosus was crushed to a particle size of about 60 meshes, and 180 grams were weighed. The drying temperature was 60°C and the drying time was 5 hours. After drying, put it into the extraction kettle, the extraction conditions are: extraction pressure is 25MPa, temperature is 35°C; separation conditions are: first-stage separation kettle pressure is 6MPa, temperature is 40°C, second-stage separation kettle pressure is 5MPa, temperature is 45 ℃. 75% ethanol is used as an entrainer. After 4 hours of dynamic operation. From the primary separation kettle and the secondary separation kettle, 654ml of the isotriazine extract was obtained, and the extract was concentrated and dried under vacuum to obtain isotriazine. The relative content of isotriazine is 63.54%, and the yield is 0.5229‰ (weight of solid product / dry weight of raw material).

[0024] Take out the waste residue in the supercritical extraction kettle, extract with 8 times the volume of ...

Embodiment 3

[0027] The rhizome of Acanthopanax senticosus was crushed to a particle size of about 80 mesh, and 180 grams were weighed. The drying temperature was 60°C and the drying time was 6 hours. After drying, put it into the extraction kettle, the extraction conditions are: extraction pressure is 30MPa, temperature is 50℃; separation conditions are: first-stage separation kettle pressure is 6MPa, temperature is 50°C, second-stage separation kettle pressure is 5MPa, temperature is 45 ℃. 55% ethanol is used as an entrainer. After 5 hours of dynamic operation. From the primary separation kettle and the secondary separation kettle, 654ml of the isotriazine extract was obtained, and the extract was concentrated and dried under vacuum to obtain isotriazine. Among them, the relative content of isotriazine is 62.25%, and the yield can reach 0.5324‰ (weight of solid product / dry weight of raw material).

[0028] Take out the waste residue in the supercritical extraction kettle, extract with 7 time...

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Abstract

The production process for preparing isoforaxidin, eleutheroside and eleutheran by using acanthopanax senticosus includes the following steps: pulverizing and drying dried root and rhizonce of acanthopanax senticosus, supercritical CO2 extraction to obtain isoforaxidin, using ethyl alcohol to extract waste residue produced after supercritical CO2 extraction at normal temp., concentrating extract,macroporous resin column chromatograph, elution, concentrating eluent, dreeze-drying and processing to obtain eleutheroside decolouring concentrated extract adsorbed by resin, concentrating and freeze-drying so as to obtain eleutheran. The complete technological process adopts high-effective liquid-phase quality control method, its product yield is high, and its purity is high.

Description

Technical field [0001] The present invention relates to a method for producing isazidine, acanthopanax senticosus glycoside and acanthopanax senticosus polysaccharide by using Acanthopanax senticosus. Background technique [0002] Acanthopanax senticosus is a typical medicinal plant in Northeast my country. Its main active ingredients are isorazidine, acanthopanax glucoside, and Acanthopanax senticosus polysaccharides. Among them, acanthopanax has an effect on the cardiovascular system. The anti-fatigue, anti-aging, anti-tumor effects of five Chinese glycosides, as well as the immune-enhancing effects of Acanthopanax senticosus polysaccharide, have been confirmed by scholars at home and abroad. Moreover, the above-mentioned substances have almost no toxic and side effects, and all have good medical application prospects. [0003] The Patent Office of the People’s Republic of China published the Acanthopanax senticosus injection freeze-dried powder injection and the used Acanthopa...

Claims

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Application Information

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IPC IPC(8): C07D311/20C07H1/08C07H15/203C08B37/00
CPCY02P20/54
Inventor 祖元刚李庆勇付玉杰张宝友李春英赵春建王化田
Owner NORTHEAST FORESTRY UNIVERSITY
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