The invention relates to man health-care medicinal liquor and a preparation method thereof. The health-care medicinal liquor comprises the following components: cervus elaphus Linnaeus, hairy antler, sea horse, cervus elaphus kidney, donkey kidney, dog kidney, gecko, epimedium, medicinal indianmulberry root, tuber onion seed, dried shrimps, desertliving cistanche, south dodder seed, psraleae, flastem milkvetch seed, common fenugreek seed, cassia bark, mantis egg-case, fortune's drynaria rhizome, honey, crystal sugar and distilled spirit. The health-care medicinal liquor follows the scientificmixing principle of Chinese medicines, has the effects of tonifying qi, strengthening kidney, replenishing essence, benefiting marrow, regulating yin-yang balance, enhancing sexual functions, improving immunity and the like, is exquisite in raw materials and strict, has a strict preparation process and does not have side effect.