32 results about "Dextromethorphan hbr" patented technology

The invention discloses a preparation process for a key intermediate 1-(4-methoxyl)benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer) of dextromethorphan hydrobromide serving as a cough relieving medicine, which comprises the following steps of: performing acylation reaction to obtain 1-(4-methoxyl)benzyl-2-alkylacyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (laevo isomer); and racemizing under the alkaline condition to obtain 1-(4-methoxyl)benzyl-2-alkylacyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer); and hydrolyzing under the alkaline condition to obtain the 1-(4-methoxyl)benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer). The process aims to overcome the defect of the synthetic process and reduce cost, so that the process is simply and safely operated, the industrial production is qualified, and the yield of products is between 55 and 69 percent.

The invention relates to an anti-cold drug suitable for children aged 4-11 years old and a preparation method of the drug. Dextromethorphan hydrobromide and phenylephrine hydrochloride are taken as active ingredients, a pH regulator is added to regulate the pH value to 3.8 +/- 2, and auxiliary ingredients such as a cosolvent, a stabilize, a thickening agent, a bacteriostat and the like are added,so that the defects in the prior art are effectively solved, and the stability of the drug is increased. At the same time, a certain amount of flavoring agent and aromatic agent are added to improve the compliance of children. The drug is mainly used for relieving nasal obstruction and cough caused by common cold of children aged 4-11 years old.

The invention belongs to the technical field of medicinal preparations, and discloses dextromethorphan chewing gum tablets and an industrially applicable preparation method thereof. The preparation is delivered through a chewing process, so that the defects of the marketed products at present can be overcome, and the tablets have the advantages of no need of water for taking, convenience in taking, good mouthfeel, less adverse effects, quick response, capability of eliminating thirst and the like. The dextromethorphan chewing gum tablets prepared by the invention are mainly used for dry coughand are suitable for cold, acute or chronic bronchitis, bronchial asthma, faucitis, phthisis and cough during other upper respiratory tract infections. The dextromethorphan chewing gum tablets provided by the invention have the advantages of simple preparation process, low cost, easiness in control and easiness for industrial production.

The invention relates to a granule containing dextromethorphan hydrobromide and guaiacol glyceryl ether and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The granules are composed of dextromethorphan hydrobromide cyclodextrin inclusion compound, guaiacol glycerin ether, diluent and binder, wherein the dextromethorphan hydrobromide cyclodextrin inclusion compound The molar ratio of the dosage of dextromethorphan hydrobromide to the cyclodextrin is 1:1-1:3, and the cyclodextrin is hydroxypropyl-β-cyclodextrin. The granule containing dextromethorphan hydrobromide and guaiacol glyceryl ether of the present invention has good stability and good taste, and at the same time solves the problem that the blood concentration of dextromethorphan hydrobromide fluctuates greatly in patients after taking the medicine, and is effective Reduced drug side effects.

The invention provides a stable dextromethorphan hydrobromide, chlorphenamine maleate and ammonium chloride oral solution and a preparation method thereof. The dextromethorphan hydrobromide, chlorphenamine maleate and ammonium chloride oral solution is prepared from 0.03-0.3% (w/v) of dextromethorphan hydrobromide, 0.01-0.2% (w/v) of chlorpheniramine maleate, 0.1-3.0% (w/v) of ammonium chloride, 0.02-5% (w/v) of a pH regulator, 0.01-2% (w/v) of an aromatizer, 0.008-0.1% (w/v) of a colorant, water and 10%-25% (w/v) of propylene glycol. The stable dextromethorphan hydrobromide, chlorphenamine maleate and ammonium chloride oral solution can take effect quickly; the prescription does not contain sucrose, so that incompatibility of sucrose with ammonium chloride is avoided; preservatives are not contained, and the safety of the solution is improved; the solubility of dextromethorphan hydrobromide is increased by using the propylene glycol; and the content of the propylene glycol is 10%-25%,the antibacterial effect is obvious, and the preservatives do not need to be added.

The invention relates to a dextromethorphan hydrobromide injection prepared from the following raw materials: 15g of dextromethorphan hydrobromide, 13g of lactic acid, 7g of sorbic acid, 42g of polyethylene glycol 2000 and 2000ml of water for injection through adjusting the pH value to 3.4-3.5.

The invention belongs to the technical field of organic chemistry, and particularly relates to a synthesis method of a compound 2-(1-cyclohexenyl) ethylamine (I). Cyclohexanone (II) and a Grignard reagent are subjected to a Grignard reaction in an organic solvent to be converted into 1-vinyl cyclohexanol (III), the 1-vinyl cyclohexanol (III) and a chlorination reagent are subjected to a chlorination/rearrangement one-pot reaction in an organic solvent in the presence of organic alkali to prepare (2-chloroethylene methylene) cyclohexane (IV), the (2-chloroethylene methylene) cyclohexane (IV) and urotropine are subjected to quaternization in an organic solvent to form N-cyclohexylidene ethyl urotropine hydrochloride (V), and finally, hydrolysis rearrangement is carried out in a solvent in the presence of inorganic mineral acid to obtain the 2-(1-cyclohexenyl) ethylamine (I). The compound (I) has important industrial application value as an intermediate for synthesizing the antitussive drug dextromethorphan hydrobromide. The method has the advantages of cheap and accessible raw materials, mild reaction conditions, high yield and high product purity, is simple to operate, and is convenient for industrial production.

The invention discloses a preparation method of a compound of dextromethorphan hydrobromide N-oxide impurity as shown in the formula I. The invention provides a preparation method of a dextromethorphan hydrobromide N-oxide impurity as shown in the formula I, comprising the following steps: dissolving dextromethorphan hydrobromide in water, dissociating by using alkali, extracting by using an organic solvent, and reacting under the action of an oxidizing agent. The preparation method of the invention is convenient to operate, the reaction condition is mild and controllable, reaction stability is high, yield of the reaction product is high, and purity is also high.

A dextromethorphan hydrobromide transdermal patch comprises a medicine carrying layer, a backing layer and an anti-sticking layer, and the medicine carrying layer is composed of dextromethorphan hydrobromide, a penetration enhancer and a pressure-sensitive adhesive matrix, and the weight percentage content of dextromethorphan hydrobromide in the medicine carrying layer is 2%-4%. The weight percentage of the penetration enhancer in the medicine carrying layer is 1%-3%, and the penetration enhancer is propylene glycol, myristic acid and menthone in the weight ratio of 1: (0.2-0.4): (0.1-0.2), wherein the pressure-sensitive adhesive matrix is a polysiloxane pressure-sensitive adhesive matrix.

The invention discloses a method for detecting the content of multiple components in an amimex oral solution by using an HPLC method, and the chromatographic conditions of the HPLC method are as follows: octadecylsilane bonded silica is used as filler, a mixed solution of a phosphate buffer solution and methanol is used as a mobile phase A, and a mixed solution of the phosphate buffer solution andacetonitrile is used as a mobile phase B for gradient elution, the flow rate is 0.5-1.5ml/min, the column temperature is 25-40DEG C, and the detection wavelength is 200-254nm. The method can be usedfor simultaneously detecting acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate and propyl gallate in the amimex oral solution, and identifying components of common peaks, and has the advantages of good reproducibility and high accuracy, and is suitable for the quality control of the active ingredient content of the amimex oral solution.

The invention discloses a compound preparation for treating cold. The compound preparation is a liquid preparation, comprises a solution consisting of purified water, dextromethorphan hydrobromide, acetaminophen and phenylephrine hydrochloride, and further comprises a pH regulator, a preservative, an antioxidant, a sweetening agent and a cosolvent. According to the compound oral solution containing the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride, a flavoring agent is added, so that the compound oral solution tastes good and is particularly suitable for children; a pH regulator buffer system is adopted, so that the pH value of the product is stable; a bacteriostatic agent is added, so that microbial growth can be prevented, and chemical degradation is remarkably reduced; the compound oral solution consisting of the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride is high in stability; the antioxidant is added, so that the chemical degradation is remarkably reduced; and the preparation process is simple, the quality is controllable, the production cost is low, and the compound preparation is suitable for large-scale production.