32 results about "Dextromethorphan hbr" patented technology

The invention provides a dextromethorphan hydrobromide oral dispersible film agent. The film agent comprises dextromethorphan hydrobromide, polacrilin or polacrilin potassium with grain diameter of 50-150mu m, a film forming agent, a plasticizer, a disintegrating agent, a wetting agent and water, wherein dextromethorphan hydrobromide and polacrilin or polacrilin potassium form a dextromethorphan hydrobromide compound, and the weight ratio of dextromethorphan hydrobromide to polacrilin or polacrilin potassium is 1:1-1:2, and preferably 1:1.3-1:1.5; the film forming agent comprises hydroxypropyl methylcellulose E3 and hydroxypropyl methylcellulose E50. The invention also provides a preparation method of the dextromethorphan hydrobromide oral dispersible film agent. The dextromethorphan hydrobromide oral dispersible film agent can well solve the problem of poor taste of dextromethorphan hydrobromide, is particularly suitable for children and old patients, and can remarkably improve the compliance of patients. An oral film tablet is nicer by an optimal preparation method.

The invention discloses a method for detecting the content of various components in the oral solution of Ammeguasu by HPLC. The chromatographic conditions of the HPLC method are as follows: octadecylsilane bonded silica gel is used as filler, and phosphate The mixture of buffer solution and methanol is mobile phase A, the mixture of phosphate buffer solution and acetonitrile is mobile phase B for gradient elution, the flow rate is 0.5-1.5ml per minute, the column temperature is 25-40°C, and the detection wavelength 200‑254nm. The present invention can not only detect acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate and peproterate in the oral solution of Ammegualine simultaneously, but also have a common peak among them All components are identified, have good reproducibility and high accuracy, and are suitable for the quality control of the active component content of the ammeguabu oral solution of the present invention.

The invention belongs to the technical field of medicinal preparations, and discloses dextromethorphan chewing gum tablets and an industrially applicable preparation method thereof. The preparation is delivered through a chewing process, so that the defects of the marketed products at present can be overcome, and the tablets have the advantages of no need of water for taking, convenience in taking, good mouthfeel, less adverse effects, quick response, capability of eliminating thirst and the like. The dextromethorphan chewing gum tablets prepared by the invention are mainly used for dry coughand are suitable for cold, acute or chronic bronchitis, bronchial asthma, faucitis, phthisis and cough during other upper respiratory tract infections. The dextromethorphan chewing gum tablets provided by the invention have the advantages of simple preparation process, low cost, easiness in control and easiness for industrial production.