Compound dextromethorphan oral solution, preparation method thereof and use thereof

A technology of dextromethorphan and oral solution, which is applied in the field of compound dextromethorphan oral solution and its preparation, and can solve the problems of excessive dosage, difficulty in taking the specification, and few dosage forms, etc.

Inactive Publication Date: 2019-10-15
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention is a kind of new medicine that is developed in view of the defects such as few kinds of cold medicines for children in my country, less dosage forms, too large dosage, incomplete specifications and difficult to take because of its taste. The present invention is a compound dextromethorphan oral solution, which can Treats and relieves common cold and flu symptoms such as nasal congestion, coughing and coughing intensity due to minor throat and bronchial inflammations, helps your child sleep, treats and relieves minor aches, headaches, sore throats, temporarily reduces fever Helps loosen phlegm (mucus) and bronchiolar secretions

Method used

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  • Compound dextromethorphan oral solution, preparation method thereof and use thereof
  • Compound dextromethorphan oral solution, preparation method thereof and use thereof
  • Compound dextromethorphan oral solution, preparation method thereof and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] prescription:

[0048] 1. Active ingredients: 34.00g of paracetamol, 21.50g of glyceryl guaiacol, 0.47g of phenylephrine hydrochloride, 0.95g of dextromethorphan hydrobromide

[0049] 2. Other auxiliary components: propyl gallate 1.75g, propylene glycol 300.00g, glycerin 100.00g, sorbitol 95.00g, xanthan gum 1.00g, potassium hydrogen phosphate 1.70g, potassium dihydrogen phosphate 1.00g, edetate di Sodium 0.40g, sucrose 100.00g, sorbic acid 1.95g, allura red pigment 34.00mg and apple essence 3.00ml, add purified water to 1000ml.

[0050] Preparation:

[0051] 1. Accurately weigh 34.0g of paracetamol and 21.5g of guaiacol glyceryl ether in a 500ml volumetric flask, and then add 95.0g, 1.00g of xanthan gum, 1.70g of potassium hydrogen phosphate, and potassium dihydrogen phosphate 1.00, 1.95g of sorbic acid, 0.40g of disodium edetate, shake to make the solid dispersed evenly, then add 300.00g of propylene glycol and 100.00g of glycerin, shake to dissolve the solid, add t...

Embodiment 2

[0053] Prescription: 1. Active ingredients: acetaminophen 28.00g, guaiacol glyceryl ether 20.00g, phenylephrine hydrochloride 0.60g, dextromethorphan hydrobromide 1.00g,

[0054] 2. Other auxiliary components: 1.60g tert-butylhydroquinone, 300.00g propylene glycol, 150.00g glycerin, 100.00g sucrose, 0.90g poloxamer, 1.80g anhydrous citric acid and 0.90g sodium citrate , 0.60g phosphoric acid, 2.10g sodium benzoate and 35.00mg brilliant blue pigment and 3.50ml red grape essence, add deionized water to 1000ml.

[0055] Preparation method: 1. Weigh the prescribed amount of propylene glycol and glycerin, put them in a 1000mL beaker, heat them in a water bath at 60°C, add the prescribed amount of poloxamer in sequence, shake well, and accurately weigh the prescribed amount of acetaminophen , guaiacol glycerin, uniformly dissolved to obtain material a;

[0056] 2. Weigh the prescription amount of sucrose, phosphoric acid, anhydrous citric acid, sodium citrate, and sodium benzoate, ...

Embodiment 3

[0060] 1. Active ingredients: 32.5g of paracetamol, 20.00g of guaiacol glyceryl ether, 0.60g of phenylephrine hydrochloride, 1.00g of dextromethorphan hydrobromide,

[0061] 2. Other auxiliary components: edetate disodium, 0.5g glycerin 200g, propylene glycol, 300.00g xanthan gum 0.95g, anhydrous citric acid and 1.90g sodium citrate 1.00g, sorbitol 100.0g, trichloro Sucrose 2.5g, sodium benzoate 2.00g, propyl gallate 2.00g, brilliant blue pigment 28.5mg, allure red pigment 5.0mg and red grape essence 1.5ml, add deionized water to 1000ml.

[0062] Preparation:

[0063] Weigh 200g of glycerin and 300g of propylene glycol, put them in a 1000mL beaker, place them in a water bath at 60°C, add 0.95g of xanthan gum, 32.50g of acetaminophen, and 20.00g of guaiacol glycerol in sequence, and stir evenly to obtain material a;

[0064] 12.2. Weigh 100g of sorbitol, 0.5g of edetate disodium, 1.00g of sodium citrate, 1.90g of anhydrous citric acid, 2.50g of sucralose, and 2.00g of sodium ...

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Abstract

The present invention provides a compound dextromethorphan oral solution preparation, a preparation method thereof and a use thereof. The compound dextromethorphan oral solution preparation is prepared by using acetaminophen, guaiacol glyceryl ether, phenylephrine hydrochloride and dextromethorphan hydrobromide as active drugs, and combining a certain amount of stabilizers, solubilizers, thickeners, suspending agents, emulsifiers, pH adjusters, preservatives, corrigents suitable for children to accept and other accessory materials, and processed by a scientific method. The compound dextromethorphan oral solution is suitable for consumption of children aged 6-12 years old. The compound dextromethorphan oral solution can treat and alleviate symptoms of common colds and flu, such as nasal congestion, cough and intensity of impulsivity caused by mild throat and bronchial inflammation and cough, can treat and alleviate mild pains and headache, and sore throat, and temporarily reduces fever.

Description

technical field [0001] The invention belongs to the technical field of chemical medicine research and development, and in particular relates to a compound dextromethorphan oral solution and its preparation method and application. Background technique [0002] Respiratory diseases are mostly caused by viruses or germs. Symptoms such as nasal congestion, runny nose, cough, sneezing, fever or headache, etc., if not treated in time, can cause many complications, such as pneumonia, myocarditis, etc., which will bring serious health problems to people. harm. [0003] The drugs usually used to treat the above symptoms are mostly antihistamines, antitussives, expectorants, narcotics, antipyretics, and anti-inflammatory drugs. Its dosage form is mostly reflected in dosage forms such as syrup, tablet, capsule, oral liquid, effervescent tablet. [0004] Products that relieve the above symptoms, such as phenylephrine, guaiacol, chlorpheniramine, dextromethorphan, acetaminophen and oth...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K31/167A61K31/09A61K31/137A61K9/08A61K47/10A61P11/00A61P31/16A61P29/00
CPCA61K9/0095A61K31/09A61K31/137A61K31/167A61K31/485A61K47/10A61P11/00A61P29/00A61P31/16A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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