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Method for detecting content of multiple components in amimex oral solution by using HPLC method

A technology for oral solution and content, which is used in measurement devices, material separation, and analysis of materials, etc., can solve the problems of inaccurate measurement results, and achieve the effects of fast analysis, good peak shape, and good repeatability.

Active Publication Date: 2021-03-19
SICHUAN FENGCHUN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for detecting the content of various components in the aminomeguasu oral solution by using the HPLC method, so as to solve the problem of inaccurate measurement results caused by the existing method of simultaneously measuring multiple components in the aminomeguasu compound preparation

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  • Method for detecting content of multiple components in amimex oral solution by using HPLC method
  • Method for detecting content of multiple components in amimex oral solution by using HPLC method
  • Method for detecting content of multiple components in amimex oral solution by using HPLC method

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Embodiment

[0039]1. Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as a filler (ACE ExcelC18, 4.6mm×250mm, 5μm) chromatographic column; use phosphate buffer solution (containing sodium dihydrogen phosphate 30mmol / L , sodium octane sulfonate 2.50g / L, adjust pH to 3.0 with phosphoric acid)-methanol (90:10) is mobile phase A, with above-mentioned phosphate buffer solution-acetonitrile (25:75) as mobile phase B, according to the table 1 Carry out gradient elution, the flow rate is 1.0ml per minute, the column temperature is 30°C, and the detection wavelength is 220nm.

[0040] Table 1 Gradient elution

[0041]

[0042] 2. Preparation of the reference substance solution: Take an appropriate amount of paracetamol, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate, and pepropropyl ester, weigh them accurately, and use mobile phase A Dissolve and quantitatively dilute to make about 325.0 μg of p...

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Abstract

The invention discloses a method for detecting the content of multiple components in an amimex oral solution by using an HPLC method, and the chromatographic conditions of the HPLC method are as follows: octadecylsilane bonded silica is used as filler, a mixed solution of a phosphate buffer solution and methanol is used as a mobile phase A, and a mixed solution of the phosphate buffer solution andacetonitrile is used as a mobile phase B for gradient elution, the flow rate is 0.5-1.5ml / min, the column temperature is 25-40DEG C, and the detection wavelength is 200-254nm. The method can be usedfor simultaneously detecting acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate and propyl gallate in the amimex oral solution, and identifying components of common peaks, and has the advantages of good reproducibility and high accuracy, and is suitable for the quality control of the active ingredient content of the amimex oral solution.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to a method for detecting the contents of various components in ammeguabu oral solution by HPLC. Background technique [0002] Ammegualine Oral Solution is composed of active ingredients acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride and a certain amount of inactive ingredients such as solubilizers, flavoring agents, preservatives It is composed of auxiliary materials such as anti-oxidant, antioxidant, oxygen-promoting agent, PH regulator, etc. It is a medicine for treating children with multi-symptom cold and fever. It can treat and relieve common cold and flu symptoms, such as nasal congestion, cough and mild throat and bronchial inflammation The intensity of the urge to cough can treat and relieve minor aches, headaches, sore throats, temporarily reduce fever, and help loosen the flow of phlegm (mucus) and bronchiolar secr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679
Inventor 何德中杜鸿儒曲韵智钟茂团钟小莉刘亚
Owner SICHUAN FENGCHUN PHARMA
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