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Compound preparation for treating cold and preparation method thereof

A technology for compound preparations and colds, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of affecting drug safety and efficacy, high preparation costs, and increasing impurities. Low production cost, controllable quality, and the effect of preventing microbial growth

Pending Publication Date: 2022-01-07
合肥远志医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the compound preparations of aminomeparin are tablets, capsules, etc., and there are few solutions. This is because there are phenolic hydroxyl groups in the molecular structure of acetaminophen and phenylephrine hydrochloride, and there is oxygen in the solution. Oxidation easily occurs under the environment, which will reduce the content, increase impurities, and affect the safety and efficacy of drugs
[0004] Application Publication No. CN112716956A discloses "a daily-use compound preparation for treating colds and its preparation method" which adopts the method of wrapping the prepared solution with soft capsules to increase the stability of the sample. The preparation cost is relatively high and the process is comparatively complex

Method used

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  • Compound preparation for treating cold and preparation method thereof
  • Compound preparation for treating cold and preparation method thereof
  • Compound preparation for treating cold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of compound preparation for treating cold, its solution composition ratio is as follows:

[0025]

[0026]

[0027] The preparation method is as follows: 1) preparation of simple syrup: add 40% of the prescription amount of purified water into the batching tank, add the sweetener into the batching tank, stir and heat until dissolved;

[0028] 2) Preparation of the main drug solution: Add co-solvent into the batching tank, heat to 60°C, add acetaminophen and dextromethorphan hydrobromide, stir to dissolve;

[0029] 3) Preparation of the main drug solution: add 6% purified water into the batching tank, add phenylephrine hydrochloride, and stir to dissolve;

[0030] 4) Preparation of auxiliary material solution: add 6% purified water into the ingredient tank, add preservative, and stir to dissolve;

[0031] 5) Preparation of auxiliary material solution: add 6% purified water into the batching tank, and add the prepared amount of pH regulator, stir to dissolve...

Embodiment 2

[0034] A kind of compound preparation for treating cold, its solution composition ratio is as follows:

[0035]

[0036]

[0037] The preparation method is as follows: 1) preparation of simple syrup: add 40% of the prescription amount of purified water into the batching tank, add the sweetener into the batching tank, stir and heat until dissolved;

[0038] 2) Preparation of the main drug solution: Add co-solvent into the batching tank, heat to 60°C, add acetaminophen and dextromethorphan hydrobromide, stir to dissolve;

[0039] 4) Preparation of main drug solution: add 6% purified water into the batching tank, add phenylephrine hydrochloride, stir to dissolve;

[0040] 4) Preparation of auxiliary material solution: add 6% purified water into the ingredient tank, add preservatives and antioxidants, stir to dissolve;

[0041] 5) Preparation of auxiliary material solution: add 6% purified water into the batching tank, and add the prepared amount of pH regulator, stir to di...

Embodiment 3

[0049] A kind of compound preparation for treating cold, its solution composition ratio is as follows:

[0050]

[0051]

[0052] The preparation method is as follows: 1) Weighing acesulfame-K and maltitol, putting it into a batching bucket, adding an appropriate amount of purified water, heating, stirring and dissolving completely, and setting aside;

[0053]2) Weigh acetaminophen, dextromethorphan hydrobromide, phenylephrine hydrochloride, propylene glycol, glycerin, and an appropriate amount of purified water, put them in a batching bucket and heat to 60°C to dissolve, then pour into the solution obtained in step 1) , and rinse the container with an appropriate amount of purified water, stir evenly, and set aside;

[0054] 3) Weigh sodium citrate, disodium edetate, sodium benzoate, and an appropriate amount of purified water, stir and dissolve in the batching bucket, pour into the above mixed solution, and rinse the container with an appropriate amount of purified wat...

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Abstract

The invention discloses a compound preparation for treating cold. The compound preparation is a liquid preparation, comprises a solution consisting of purified water, dextromethorphan hydrobromide, acetaminophen and phenylephrine hydrochloride, and further comprises a pH regulator, a preservative, an antioxidant, a sweetening agent and a cosolvent. According to the compound oral solution containing the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride, a flavoring agent is added, so that the compound oral solution tastes good and is particularly suitable for children; a pH regulator buffer system is adopted, so that the pH value of the product is stable; a bacteriostatic agent is added, so that microbial growth can be prevented, and chemical degradation is remarkably reduced; the compound oral solution consisting of the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride is high in stability; the antioxidant is added, so that the chemical degradation is remarkably reduced; and the preparation process is simple, the quality is controllable, the production cost is low, and the compound preparation is suitable for large-scale production.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to a compound preparation for treating colds and a preparation method thereof. Background technique [0002] Ammelenin Oral Liquid is a compound preparation, active ingredients dextromethorphan hydrobromide, phenylephrine hydrochloride, acetaminophen, inactive ingredients antioxidants, preservatives, sweeteners, pH regulators, etc. Excipient composition. Symptoms of cold and fever include nasal congestion, cough, pain, fever and other symptoms. In order to achieve the effect of taking several medicines in the treatment of colds, acetaminophen oral liquid is a compound preparation, and the acetaminophen in it can relieve fever Analgesic, dextromethorphan hydrobromide can antitussive, phenylephrine hydrochloride can be used as a nasal decongestant to relieve nasal congestion, only need to take this one to achieve the treatment of various symptoms caused by colds, and this product is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/167A61K31/137A61K9/08A61K47/26A61K47/12A61K47/22A61K47/02A61P11/00
CPCA61K31/167A61K31/485A61K31/137A61K9/0095A61K47/26A61K47/12A61K47/22A61K47/02A61P11/00A61K2300/00
Inventor 白中稳孙松鲍大万于丹
Owner 合肥远志医药科技开发有限公司
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