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Compound oral disintegrating tablet containing acetaminophen and dextromethorphan

A technology of acetaminophen and orally disintegrating tablets, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas to achieve long-lasting, definite and powerful effects

Active Publication Date: 2013-06-26
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology has the following problems: ① The organic solvent cyclohexane needs to be used as a solvent for the coating material and the main drug, which increases the risk of environmental pollution and physical damage to production personnel; Risk of uniformity; ③The weight of the final prepared tablet is relatively large (greater than 1g), which reduces the compliance of patients, especially children; ④Requires special preparation process equipment

Method used

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  • Compound oral disintegrating tablet containing acetaminophen and dextromethorphan
  • Compound oral disintegrating tablet containing acetaminophen and dextromethorphan
  • Compound oral disintegrating tablet containing acetaminophen and dextromethorphan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of coated granules with ethyl cellulose as coating material and tableting

[0034] prescription:

[0035]

[0036] Preparation Process:

[0037] Preparation of drug-containing granules:

[0038] 1. Preparation of adhesive: Weigh an appropriate amount of hypromellose and add it to purified water, stir to dissolve, and prepare a 4% (w / v) hypromellose aqueous adhesive.

[0039] 2. Crush acetaminophen, dextromethorphan hydrobromide, and sucrose separately, pass through an 80-mesh sieve, and set aside.

[0040] 3. Weigh the prescribed amount of acetaminophen, dextromethorphan hydrobromide fine powder, and sucrose respectively, mix well, and set aside.

[0041] 4. Granulation: Add the mixture of raw and auxiliary materials under item 3 into the centrifugal pelletizer, and set the equipment parameters as follows: fan frequency 10Hz, turntable speed 250rpm, spray speed 10rpm, spray gun pressure 0.02MPa, during the granulation process according to A...

Embodiment 2

[0056] Example 2: Preparation of coated granules with ethyl cellulose as coating material and tableting

[0057] prescription:

[0058]

[0059] The preparation process of drug-containing granules, coated granules and compressed tablets is the same as in Example 1. The average tablet weight of the prepared orally disintegrating tablets is 750 mg, the hardness is 3-4 kg, and the disintegration time limit is less than 60 s.

[0060]

Embodiment 3

[0061] Example 3: Preparation of coated granules with ethyl cellulose as coating material and tableting

[0062] prescription:

[0063]

[0064] The preparation process of drug-containing granules, coated granules and compressed tablets is the same as in Example 1. The average tablet weight of the prepared orally disintegrating tablets is 750 mg, the hardness is 3-4 kg, and the disintegration time limit is less than 60 s.

[0065]

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Abstract

The invention relates to the field of pharmaceutical preparation, and in particular relates to a compound oral disintegrating tablet containing acetaminophen and dextromethorphan hydrobromide. The compound oral disintegrating tablet contains the following components of: a. acetaminophen and dextromethorphan hydrobromide coating particles, wherein the particle diameter of the coating particles is 60-100 meshes, the coating particles contain particles including acetaminophen and dextromethorphan hydrobromide, a coating material coated on the particle surface, and the coating material comprises ethylcellulose and at least one pore-foaming agent; b. a filler which is directly compressible mannitol, mannitol, microcrystalline cellulose or a mixture thereof; c. a disintegrating agent selected from crospolyvinylpyrrolidone or croscarmellose sodium; d. a lubricant which is talcum powder or magnesium stearate; and e. an effervescing agent.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound orally disintegrating tablet containing acetaminophen and dextromethorphan hydrobromide and a preparation method thereof. technical background [0002] Common cold is a kind of common frequently-occurring disease, generally thinks that common cold is caused by rhinovirus, because there is no specific medicine for virus at present, so mainly adopt symptomatic treatment. There are many kinds of cold symptoms, mainly including fever, rhinorrhea, cough, nasal congestion, etc. These symptoms often do not appear at the same time, and "all-purpose" cold medicines often contain one or two ingredients for those who do not have symptoms. This undoubtedly increases the economic burden of treatment for patients, and more seriously, may cause unnecessary side effects. It is wiser to treat with specific preparations that target the relief of the most uncomfortable cold s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/167A61K9/20A61K47/32A61K47/34A61K47/38A61P29/00A61P25/04A61P11/14A61K47/10
Inventor 肖波张涛王立欧云国万娟
Owner CHONGQING PHARMA RES INST
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