Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dextromethorphan hydrobromide related substance detection method

A technology of dextromethorphan hydrobromide and its detection method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems that the separation degree cannot meet the requirements, and cannot meet the simultaneous determination of five impurities, etc.

Pending Publication Date: 2022-05-27
SHIJIAZHUANG YILING PHARMA
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] From the above spectrum, it can be seen that the resolution of related substances of dextromethorphan cannot meet the requirements by using the existing technology, so the purpose of simultaneous determination of five impurities cannot be met.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dextromethorphan hydrobromide related substance detection method
  • Dextromethorphan hydrobromide related substance detection method
  • Dextromethorphan hydrobromide related substance detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] 1. Experimental part

[0092] 1.1 Instruments, reagents and materials

[0093] Waters e2695 high performance liquid chromatograph (Empower chromatography workstation); S210 pH meter (Mettler), XPE 105 electronic analytical balance (Mettler).

[0094] Sodium dioctyl sulfosuccinate (chemically pure, 96% pure, 97% pure, 99% pure and 99.0% pure) were purchased from Sinopharm Chemical Reagent Co., Ltd., Shandong West Asia Chemical Co., Ltd., Bailingwei and Sigma- Aldrich Company; glacial acetic acid (analytical grade) was purchased from Tianjin Damao; acetonitrile (chromatographic grade) was purchased from Merck Company, Germany; sodium nitrate and phosphoric acid (analytical grade) were purchased from Tianjin Comeo Co., Ltd.

[0095] Dextromethorphan hydrobromide impurity I, impurity II, impurity III and impurity IV reference substance were purchased from LGC in England; Dextromethorphan hydrobromide impurity D reference substance was purchased from TRC in Canada.

[0096...

Embodiment 2

[0104] 1. Experimental part

[0105] 1.1 Instruments, reagents and materials

[0106] Waters e2695 high performance liquid chromatograph (Empower chromatography workstation); S210 pH meter (Mettler), XPE 105 electronic analytical balance (Mettler).

[0107] Sodium dioctyl sulfosuccinate (chemically pure, 96% pure, 97% pure, 99% pure and 99.0% pure) were purchased from Sinopharm Chemical Reagent Co., Ltd., Shandong West Asia Chemical Co., Ltd., Bailingwei and Sigma- Aldrich Company; glacial acetic acid (analytical grade) was purchased from Tianjin Damao; acetonitrile (chromatographic grade) was purchased from Merck Company, Germany; sodium nitrate and phosphoric acid (analytical grade) were purchased from Tianjin Comeo Co., Ltd.

[0108] Dextromethorphan hydrobromide impurity I, impurity II, impurity III and impurity IV reference substance were purchased from LGC in England; Dextromethorphan hydrobromide impurity D reference substance was purchased from TRC in Canada.

[0109...

Embodiment 3

[0117] 1. Experimental part

[0118] 1.1 Instruments, reagents and materials

[0119] Waters e2695 high performance liquid chromatograph (Empower chromatography workstation); S210 pH meter (Mettler), XPE 105 electronic analytical balance (Mettler).

[0120] Sodium dioctyl sulfosuccinate (chemically pure, 96% pure, 97% pure, 99% pure and 99.0% pure) were purchased from Sinopharm Chemical Reagent Co., Ltd., Shandong West Asia Chemical Co., Ltd., Bailingwei and Sigma- Aldrich Company; glacial acetic acid (analytical grade) was purchased from Tianjin Damao; acetonitrile (chromatographic grade) was purchased from Merck Company, Germany; sodium nitrate and phosphoric acid (analytical grade) were purchased from Tianjin Comeo Co., Ltd.

[0121] Dextromethorphan hydrobromide impurity I, impurity II, impurity III and impurity IV reference substance were purchased from LGC in England; Dextromethorphan hydrobromide impurity D reference substance was purchased from TRC in Canada.

[0122...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
recovery rateaaaaaaaaaa
Login to View More

Abstract

The invention relates to a dextromethorphan hydrobromide related substance detection method, which can be used for simultaneously detecting five impurities and accurately determining the relative retention time and correction factor of each known impurity. The method is short in separation time, good in separation degree, low in quantification limit and accurate in result, and related substances in dextromethorphan hydrobromide can be effectively detected.

Description

technical field [0001] The invention relates to a quality control method for dextromethorphan hydrobromide, in particular to a method for detecting a related substance of dextromethorphan hydrobromide. Background technique [0002] Dextromethorphan Hydrobromide (DM) was synthesized by HoffmanRoche of Switzerland in the 1950s by modifying the structure of morphine. Its levorotatory compound has analgesic effect, and DM is a dextrorotatory morphinan derivative. It has obvious antitussive effect without analgesic effect, so it is also known as dextromethorphan. [0003] DM is white or off-white crystalline powder, odorless, easily soluble in ethanol, soluble in chloroform, slightly soluble in water, insoluble in ether, its molecular formula is C 18 H 25 NO•HBr•H 2 O, the chemical name is 3-methoxy-17-methyl-(9α,13α,14α)-morphinan hydrobromide monohydrate, the structural formula is as follows: [0004] [0005] There are 6 known impurities in the quality standard of dextr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 贾振华吴相君高翠华王展梁世如李松石静媛武玉杰
Owner SHIJIAZHUANG YILING PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com