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Hydrobromic acid dextro methaphen oral cavity disintegretion tablet and its preparation method

A technology for dextromethorphan hydrobromide and oral disintegrating tablets, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as no oral disintegrating tablets, etc. Timely and effective treatment

Inactive Publication Date: 2005-03-09
范敏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dextromethorphan hydrobromide is an antitussive drug. Common dosage forms in the market include ordinary tablets, capsules, etc. No orally disintegrating tablets are seen.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1: Add 4.0 g of dextromethorphan hydrobromide and 13.5 g of methacrylic acid copolymer resin (Eudragit L30D) into a blender, completely wet with water, and fully mix in the blender at 500 rpm. Dry in an oven at 45°C for 12 hours to constant weight. Then pulverize, add the pulverized product into a V-shaped mixer, add 57.5g of compressible sorbitol, 6.25g of citric acid, 18.75g of sodium bicarbonate, 0.5g of magnesium stearate, 0.1g of silicon dioxide, lemon Spice 0.3g, mixed evenly, and compressed into a tablet with a tablet weight of 500mg using a common tablet press.

[0010] The sample prepared by the invention disintegrates within 30 seconds in the oral cavity, is convenient to take, and can treat central cough in time with good effect.

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PUM

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Abstract

An oral disintegrating tablet of dextromethorphan hydrobromide contains dexromethorphan hydrobromide and auxiliaries including sorbitol, methylacrylic copolymer resin (Eudragit L30D), citric acid, sodium dicarbonate, magnesium stearate, SiO2 and lemon perfume.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to an orally disintegrating tablet of antitussive drug dextromethorphan hydrobromide and a preparation method thereof. Background technique [0002] Orally disintegrating tablet is a rapidly dispersing tablet that disintegrates when it comes into contact with saliva in the mouth, and is more suitable for the elderly and children with poor swallowing ability and patients in special environments (lack of water) , and the drug disintegrates quickly in the oral cavity, which can improve the efficacy of the drug and play a role quickly. Dextromethorphan hydrobromide is an antitussive drug. Common dosage forms in the market include ordinary tablets and capsules, and no orally disintegrating tablets have been seen. Contents of the invention [0003] The object of the present invention is to provide a kind of dextromethorphan hydrobromide orally...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/439A61P11/14
Inventor 范敏华
Owner 范敏华
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