Liquid composition containing phenylephrine hydrochloride as well as preparation and application thereof

A technology of phenylephrine hydrochloride and liquid composition, applied in the field of drug research and development, can solve the problems of weak sedative effect and the like

Pending Publication Date: 2020-08-28
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Pheniramine maleate: melting point 104-108°C, boiling point 489.25°C, density 1.2233, water-soluble 1g / 100mL (24°C), the drug has antihistamine and anticholinergic effects, but the sedative effect is weak

Method used

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  • Liquid composition containing phenylephrine hydrochloride as well as preparation and application thereof
  • Liquid composition containing phenylephrine hydrochloride as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065]

[0066]

[0067] Preparation method: crush guaifenesin, pass through a 200-mesh sieve to obtain guaifenesin fine powder, and set aside;

[0068] 1. Dissolve choline salicylic acid with a small amount of water to obtain solution 1, set aside;

[0069] 2. Melt / or dissolve choline salicylic acid, guaifenesin, sodium thiosulfate, propylene glycol, sucrose, xanthan gum, sodium benzoate, blueberry essence and purified water to obtain molten liquid / or dissolved liquid 2, and set aside ;

[0070] 3. Mix the solution 1 and the molten solution / or solution 2 evenly, add phenylephrine hydrochloride, add purified water to the required amount, stir, adjust the pH value to 5.7-6.3 with potassium hydrogen phosphate, and use a homogenizer (10000r / s) homogeneously to obtain the required suspension.

Embodiment 2

[0072] material name Proportion: % (g / ml) Phenylephrine Hydrochloride 0.08 Acetaminophen 3.2 Pheniramine maleate 0.08 Quinol 0.15 Propylene Glycol 0.70 stevia 0.05 xanthan gum 5.00 benzoic acid 0.20 orange flavor 0.20 Sodium dihydrogen phosphate Appropriate amount purified water to the preparation amount

[0073] Preparation method:

[0074] 1. Pulverize acetaminophen and pheniramine maleate respectively, and pass through a 200-mesh sieve to obtain acetaminophen fine powder and pheniramine maleate fine powder for subsequent use;

[0075] 2. Melt / or dissolve hydroquinone, propylene glycol, stevioside, xanthan gum, benzoic acid, and orange essence with purified water to obtain a molten liquid / or dissolved liquid for later use;

[0076] 3. Add acetaminophen fine powder and pheniramine maleate fine powder to the above molten solution / or solution and mix evenly, add phenylephrine hydrochloride, add p...

Embodiment 3

[0078] material name Proportion: % (g / ml) Phenylephrine Hydrochloride 0.03 Acetaminophen 2.17 doxylamine succinate 0.04 Dextromethorphan Hydrobromide 0.07 Sodium thiosulfate 0.20 Propylene Glycol 0.60 Glycyrrhizin 0.95 xanthan gum 5.00 sodium sorbate 0.20 orange flavor 0.20 Potassium hydrogen phosphate Appropriate amount purified water to the preparation amount

[0079] Preparation method:

[0080] 1. Grind acetaminophen and pass through a 200-mesh sieve to obtain acetaminophen fine powder, which is set aside;

[0081] 2. Dissolve dextromethorphan hydrobromide and doxamine succinate with a small amount of purified water to obtain solution 1, which is set aside;

[0082] 3. Melt and / or dissolve sodium thiosulfate, propylene glycol, glycyrrhizin xanthan gum, sodium sorbate, orange flavor and purified water to obtain molten liquid / or dissolved liquid 2 for later use;

[0083] 4. Mix the solu...

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PUM

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Abstract

The invention relates to a liquid composition containing phenylephrine hydrochloride as well as a preparation and application thereof. The composition comprises three compositions: the first is a combination of the phenylephrine hydrochloride, choline salicylic acid and guaifenesin; the second is a combination of the phenylephrine hydrochloride, acetaminophen and pheniramine maleate; and the thirdis a combination of the phenylephrine hydrochloride, the acetaminophen, dextromethorphan hydrobromide and doxylamine succinate. The composition disclosed by the invention can be prepared into a liquid preparation, and a preferable dosage form is suspension.

Description

technical field [0001] The invention belongs to the field of drug research and development, and in particular relates to a liquid composition containing phenylephrine hydrochloride for treating respiratory diseases and cold symptoms, as well as its preparation and application. Background technique [0002] Cold is a common respiratory disease. Its main symptoms are fever, nasal congestion, runny nose, cough, sneezing or headache. If it is not treated in time, it can cause many complications and bring serious harm to people's health. [0003] The medicines that are usually used to treat the above symptoms mainly include antipyretic analgesics, antihistamines, antitussives, expectorants, anesthetics, anti-inflammatory drugs and decongestants, etc., and there are many forms of products prepared by them, such as Tablets, capsules, oral liquids, ointments or lotions, etc. [0004] If multiple symptoms occur, such as fever, nasal congestion and headache, etc., the above-mentioned...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/137A61K31/167A61K31/485A61K31/4402A61K31/60A61K31/09A61P11/00A61P11/02A61P29/00A61P37/08
CPCA61K9/10A61K31/09A61K31/137A61K31/167A61K31/4402A61K31/485A61K31/60A61P11/00A61P11/02A61P29/00A61P37/08A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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