The invention discloses a method for synthesizing a
cephalosporin intermediate, which comprises the following steps: 1, adding 1-methyl-5-mercaptotetrazole and 7-amino-cephalosporanic acid into
acetonitrile with stirring, heating the solution, and adding a
boron trifluoride complex compound into the solution; 2, adding a proper amount of
active carbon into the solution, stirring and filtering thesolution, washing the carbon by using
aqueous solution of
acetone containing
hydrochloric acid, and merging filtrate; 3, adding the merged filtrate into the
aqueous solution of
acetone, stirring the solution, slowly dripping alkali solution till the pH value of the solution is 2.0 to 3.5, and growing crystals for 1 to 2 hours; and 4, filtering the solution, transferring the filtrate to another container, reclaiming the
acetonitrile and the
acetone, washing the obtained crystals twice to trice by using the acetone, filtering the solution, and then
drying the crystals under vacuum. Aiming at the problem that the conventional method for synthesizing the
cephalosporin intermediate is not suitable for industrialized production, the invention provides the method for synthesizing the
cephalosporin intermediate; the method is simple and convenient to operate, is suitable for industrialized production and has high yield; and the prepared 7-ATCA.HCl has high purity.