Penicillin fermentation broth treating technology

A penicillin fermentation and liquid treatment technology, applied in the field of penicillin fermentation liquid treatment technology, can solve problems such as environmental pollution and resource waste, and achieve the effects of reducing production costs, reducing environmental protection pressure, and shortening technological processes

Active Publication Date: 2013-07-24
河北美邦工程科技股份有限公司 +1
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Problems solved by technology

[0003] The purpose of the present invention is to provide a treatment process for penicillin fermentation liquid, which can improve the yield, simplify the process flow and solve the problems of environmental pollution and waste of resources

Method used

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  • Penicillin fermentation broth treating technology

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Embodiment 1

[0018] refer to figure 1 Shown step completes the penicillin fermented liquid processing, and concrete steps are as follows:

[0019] (1) Cool the original penicillin fermentation broth with a moisture-solid content of 30-32% to 10-15°C, and send it into a closed ceramic membrane cross-flow filtration system with a ceramic membrane filtration accuracy of 50nm. The membrane inlet pressure is 0.35-0.45 Filtration is carried out under the conditions of MPa and membrane exit pressure of 0.13-0.2MPa, and the high-potency ceramic membrane filtrate is stored. The potency of the filtrate is about 60,000-70,000 U;

[0020] (2) During the filtration process, when the moisture-solid content of the penicillin fermentation broth increases to twice the original moisture-solid content, add primary water (i.e. tap water) with a weight twice the weight of the original fermentation broth for dialysis, and the obtained low titer The ceramic membrane filtrate is stored and concentrated and dehyd...

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PUM

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Abstract

The invention discloses a penicillin fermentation broth treating technology, which comprises the following steps of: cooling an original penicillin fermentation broth, filtering the cooled penicillin fermentation broth by a closed ceramic-membrane cross-flow filtration system, and collecting high-titer ceramic-membrane filtrate; during filtration, when the wet solid content in the penicillin fermentation broth is enhanced to 1.8-2 times that of the original fermentation broth, adding water with weight accounting for 2 times that of the original fermentation broth for dialyzing to obtain and collect low-titer ceramic-membrane filtrate, and then nano-filtering, concentrating and dewatering the low-titer ceramic-membrane filtrate for later use; continuing to add water with weight accounting for 2 times that of the original fermentation broth for dialyzing to obtain and collect ultra-low-titer ceramic-membrane filtrate; stopping filtration until the titer of penicillin in the penicillin fermentation broth is low to 500-800U; collecting bacterium dregs intercepted by the ceramic-membrane filtration system; putting the high-titer ceramic-membrane filtrate in 6APA (6-aminopenicillanic acid) for conversion or oxidization, ring enlargement and cracking, thus preparing 7-ADCA (7-aminodeacetoxy cephalosporanic acid); and collecting the obtained bacterium dregs and adding engineering bacteria for decomposing the bacterium dregs.

Description

technical field [0001] The invention relates to an antibiotic production process, in particular to a penicillin fermentation broth treatment process. Background technique [0002] In the traditional process, the penicillin fermentation broth is generally filtered by plate frame or drum. This kind of filtration method not only has a yield as low as 88-89%, but also, the filtrate produced after filtration must be refined and then enter the crystallization step to obtain penicillin potassium salt; The step of 7-ADCA makes the final product. This process route not only has a low yield; the process is cumbersome, and the fungus residue produced in the production process cannot be effectively used, and can only be incinerated after drying to avoid environmental pollution caused by its direct flow into the natural environment. But this not only causes waste of resources, but also leads to high processing costs, which affects the economic benefits of enterprises. Contents of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/18C07D501/10B01D61/58
Inventor 尹更昌张玉新张卫国杜进民王素霞张志学
Owner 河北美邦工程科技股份有限公司
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