34 results about "Carbocisteine" patented technology

The invention discloses a preparation method and an application of an erythrocyte membrane-coated acid-sensitive polymer prodrug nano drug delivery system, wherein the polymer is formed by connecting sodium polyglutamate and carbocisteine through a peptide bond and then is bonded with an anti-cancer drug taxol to form the polymer prodrug; and the polymer prodrug is coated by an erythrocyte membrane to obtain an erythrocyte membrane-coated acid-sensitive polymer drug delivery system. The drug delivery system has the following characteristics that the particle size is about 100nm, and the shape is a sphere; the drug delivery system is relatively stable in a phosphate buffer and serum; the drug release character is relatively good in an acid environment; the toxicity is obviously reduced in cell experiments; the ingestion of the system by macrophage is obviously reduced; without destructive effect on erythrocyte, the system can be applied to intravenous injection; the circulating time of the system in blood is remarkably longer than that of polymer; and the system has an obvious inhibiting effect on the tumor growth of lung cancer.

The invention relates to a carbocisteine oral liquid and a preparation method thereof. The oral liquid comprises carbocisteine accounting for 2% to 10% of the oral liquid, sodium hydroxide, an antioxidant, a solution stabilizer composition, and a flavoring agent, and has a pH value of 6.0 to 7.5. The oral liquid is prepared by the following steps: carrying out salt-forming reactions between carbocisteine and a sodium hydroxide solution, then dissolving the salts into water, adding an antioxidant, a solution stabilizer composition, and a flavoring agent, stirring, adding water to a metered volume, filtering, filling the solution into cans, and finally sterilizing the cans so as to obtain the oral liquid; wherein each can contains 10 to 120 mL of oral liquid. The oral liquid is widely used to treat thick phlegm or dys-expectoration caused by chronic bronchitis, bronchus asthma, and the like, and has the characteristics of stable property, long shelf life, and safer clinical application.

The invention discloses a preparation method of carbocisteine. The preparation method comprises the three steps of condensation reaction, neutralization and crystallization, and recrystallization. Through adding carbonate and an antioxidant to a reaction system and strictly controlling reaction conditions, the content of impurity amino acid in a finished product is reduced substantially, and the purity and the product quality of carbocisteine are improved. The preparation method has the advantages of simplicity in operation, short production cycle, low cost, and the like.

The invention relates to a synthetic method of carbocisteine, wherein a two-pot reaction process in the prior art is changed into a one-pot reaction process, thereby simplifying the process and reducing devices. A low-temperature nitrogen protective process is changed into a normal-temperature nitrogen-free protective process, thereby reducing material and energy consumptions. A two-step crystallization process is changed into a one-step crystallization process, thereby reducing processes and devices and increasing the yield.

The invention discloses a medicinal composition of carbocisteine and treatment effects of the medicinal composition for leukemia. The medicinal composition of carbocisteine provided by the invention contains carbocisteine and a natural product compound (I) which is obtained by separating the dried folium pyrrosiae and has the novel structure, when carbocisteine and the natural product act independently, certain treatment effect can be achieved on leukemia, when carbocisteine and the natural product are mixed for use, the treatment effect for leukemia is more obvious, the medicinal composition can be developed into the medicine for treating leukemia, and compared with the prior art, the medicinal composition has outstanding substantive features and obvious progress.

The invention relates to a biological curing agent for natural rubber latex. A formula of the biological curing agent comprises the following components in parts by weight: 0.5-2.0 parts of water, 8-10 parts of glacial acetic acid, 0.3-0.7 part of citric acid and 0.009-0.02 part of carbocisteine. The biological curing agent is prepared by the following steps of: after the components are compounded into the formula, adding 500-800 parts of natural rubber latex, fully stirring to be uniform and curing. The biological curing agent has the beneficial effects that not only are no toxicity and harm caused, but also the environment is not polluted, the molecular structure of the rubber is not damaged, and the quality and the dry content of the natural rubber latex are improved; and the use is convenient and the cost is reduced.

The invention relates to a production process for a carbocisteine buccal tablet. The production process comprises the following steps: crushing and sieving of raw and accessory materials; weighing and batching; mixing and granulating; drying; size stabilization; total blending; tableting; packaging; and warehousing. The carbocisteine buccal tablet produced in the invention is used for cough and difficult expectoration caused by chronic bronchitis and bronchial asthma mucus; in the production process of the carbocisteine buccal tablet, crushing granularity of the main material--carbocisteine is strictly controlled so as to ensure that all the main material is crushed and sieved with a 100-mesh sieve, and control of raw material granularity provides prerequisites for rapid absorption of the carbocisteine buccal tablet; and a high-grade material of the industry is a binder, so the appearance of the tablet surface is beautiful and rapid arrival of a drug at a designated position can be promoted.

The invention relates to a carbocisteine buccal tablet. The carbocisteine buccal tablet is prepared from the following raw materials by weight: 15.014 to 15.563 parts of carbocisteine, 0.319 to 0.449 part of borneol, 0.0018 to 0.003 part of menthol, 0.004 to 0.005 part of aspartame, 54.470 to 56.544 parts of sucrose, 25.738 to 26.196 parts of mannitol, 0.479 to 0.598 part of PVPK 30, 0.958 to 2.394 parts of magnesium stearate, 0.006 to 0.021 part of lake and 0.035 to 0.048 of essence. The buccal tablet provided by the invention is used for cough and difficult expectoration caused by chronic bronchitis and bronchial asthma mucus, takes effect rapidly and has occasional or slight side effects (like dizziness, belching, nausea; and compared with a general dosage form, the carbocisteine buccal tablet provided by the invention does not need to be taken with water and is placed in an oral cavity, and the drug in the tablet is slowly dissolved and produces long-lasting and local effect.

The invention relates to carbocisteine syrup with improved water solubility and a preparation method of the carbocisteine syrup. The method comprises the following steps: weighing syrup substrate, adding an appropriate amount of purified water into the syrup substrate, carrying out complete boiling so that the syrup substrate is dissolved, carrying out filtering, carrying out standing for cooling till the temperature is 40-60 DEG C, and carrying out shaking till the product is uniform, thus obtaining simple syrup; weighing an active pharmaceutical ingredient, namely, carbocisteine, adding carbocisteine into an appropriate amount of water, slowly adding with an appropriate amount of sodium hydroxide solution under stirring, so that carbocisteine is completely dissolved (alkali is added according to the molar ratio of 1 to 1 for forming salt), adding with an appropriate amount of a preservative and an appropriate amount of a corrigent, and carrying out sufficient stirring; adding the carbocisteine solution into the simple syrup; enabling the relative density of the liquid medicine to be 1.08-1.25; adding with an appropriate amount of boiling water, carrying out stirring till the uniform state is reached, and carrying out filtering after the assay was approved after the liquid medicine is cooled to be 50 DEG C or below, and thus obtaining the filtrate, which is the syrup capable of relieving cough and eliminating phlegm. The method provided by the invention is simple in process and low in cost, the obtained carbocisteine syrup is good in water solubility, the method is suitable for industrial production, and thus the difficulties that carbocisteine has difficulty in dissolving in water, and the bioavailability is low are solved.

The invention discloses a carbocisteine tablet. The carbocisteine tablet is prepared from the following components in parts by weight: 1000 parts of carbocisteine, 120 parts of corn starch, 200 partsof pregelatinized starch, 2800 parts of powdered sugar, 200 parts of low-substituted hydroxypropyl cellulose, 500 parts of 30% ethanol, 16.5 parts of magnesium stearate, 120 parts of carboxymethyl starch sodium, 120 parts of microcrystalline cellulose, 15 parts of steviosin and 3 parts of pineapple essence. Preparation equipment comprises a mixing tank, reciprocating motion mechanisms are installed on the two sides of the mixing tank respectively, a protection box is installed on each reciprocating motion mechanism, a cavity is formed in the protection box, an automatic lifting mechanism is arranged in the cavity, a supporting column is installed on the automatic lifting mechanism, and a transverse plate is fixed to the upper end of the supporting column. According to the invention, not only can the total mixing processing capacity of the carbocisteine tablet be enlarged, but also the mixing effect during total mixing can be ensured, the processing time is greatly shortened, the processing efficiency is enhanced, and the production cost is reduced.

A pharmaceutical composition for respiratory system disease and the preparation process therefor, consisting of levodropropizine and carbocisteine as active ingredients with a pharmaceutically acceptable excipient. The present pharmaceutical composition has a marked cough-relieving effect and fewer negative reactions.

The invention provides a preparation method of lysine carbocisteine. The preparation method comprises the following steps: mixing L-lysine with a carbocisteine water solution to generate salt formingreaction, so as to obtain a salt forming product system; and carrying out spray drying on the salt forming product system, so as to obtain lysine carbocisteine. According to the preparation method, afinished product can be obtained without separation and purification through a solvent-out crystallization method, prepared lysine carbocisteine does not contain residues of organic solvents such as methanol, ethanol and acetone, the product does not have solvent residue and is uniform in particles, the impurity is not generated during the spray drying, the purity of lysine carbocisteine is accordant with that of raw material carbocisteine, and the yield is high. According to the records of an embodiment, the yield of lysine carbocisteine is 98%, and meanwhile, a large number of organic solvents are not used in the preparation method, so that the production cost can be remarkably lowered, and the environment pressure can be reduced.

The invention provides a carbocisteine ​​oral solution and a preparation method thereof, relating to the technical field of medicine, comprising carbocisteine, glycerin, lemon juice, loquat, antioxidant, solution stabilizer, flavoring agent, and pH regulator; The method comprises the following steps: (1) taking the glycerin, lemon juice and loquat dew of the formula quantity, adding ultrapure water, and ultrasonic treatment for 10-12min; (2) adding the carbocisteine ​​of the formula quantity into the solution in step (1) , heated to boiling, then stirred, and mixed evenly; (3) adding antioxidant, solution stabilizer, flavoring agent in boiling state, keeping boiling for 5‑8min, standing, and cooling to room temperature; (4) adding pH adjustment medicament, stir evenly, make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral solution. The method of the invention has simple process and low cost, and the obtained carbocisteine ​​oral solution has good water solubility and is easy to industrialized production, and solves the problems of carbocisteine ​​taste discomfort and low bioavailability.

Methods for styling, in particular for straightening, keratin fibers, in particular human hair, in which (i) a styling agent comprising carbocisteine and / or a salt thereof is applied to the keratin fibers and left there, (ii) the fibers, after a leave-in time, —are not rinsed, —are optionally dried, (iii) the fibers are mechanically deformed from exposure to heat, significantly minimize the negative consequences of styling and reduce in particular electrostatic charging and hydrophilization of the hair.

The invention discloses a method for separating and determining carbocisteine and impurities thereof by high performance liquid chromatography. The determination method adopts a chromatographic column taking octadecylsilane chemically bonded silica as a filler, and the detection conditions are as follows: chromatographic conditions: the chromatographic column is an octadecylsilane chemically bonded silica chromatographic column, a mobile phase is a phosphate-ion pair buffer solution, the pH value of the mobile phase is 1.6-2.0, and the detection wavelength is 215 nm. The method disclosed by the invention is high in precision, good in repeatability and high in recovery rate, and can be widely applied to quality detection of carbocisteine raw material medicines from different sources and corresponding preparations thereof.

The invention provides a carbocisteine composition freeze-drying tablet and a preparation method thereof, and relates to technical fields of medicines and medicine production. The carbocisteine composition freeze-drying tablet comprises carbocisteine, starch and cane sugar, wherein the starch and cane sugar are taken as auxiliary materials; by performing heating technology processing on the common corn starch, the binding effect and disintegration effect of the starch in the tablet can be improved, the formability of the tablet can be improved, and the carbocisteine composition freeze-drying tablet only requires two auxiliary materials, namely starch and cane sugar. The carbocisteine composition freeze-drying tablet adopts a freeze-drying technology of twice cooling and twice heating up which can ensure that the formability of the tablet is better, and improves the dissolution rate of the tablet, so that the bioavailability of the tablet is improved; the tablet overcomes the disadvantage of the common carbocisteine tablet, reduces the variety and the use level of the auxiliary materials in the carbocisteine tablet, is high in dissolution rate and high in bioavailability, and guarantees the curative effect and safety of clinical medication.

The invention discloses a cosmetic which can balance oil secreting, resist sunlight and skin aging and essentially consists of rennin, honey, titanium dioxide, carbocisteine, niacin amide, vitamin E, vitamin F, cod liver oil, spironolactone and substrate cream, which are prepared according to certain weight proportion and function coordinately to achieve the effect of whitening and skincare. The invention has the triple effects including skincare, sun block and aging resistance. Firstly, the cosmetics regulates the metabolism of skin oil secretion to balance the secretion of the oil secretion, smoothen pores and reduce the occurrence rate of acne; secondly, the product effectively prevents people from being hurt by ultraviolet and reduces the settlement of melanin, thereby having good sun block and whitening effects; finally, the product slows down the aging of skin, smoothens the skin and provides delicate and fair skin to users. The invention has scientific components, simple fabrication and unique treatment effect and is suitable for large-batch production.

The invention relates to a biological curing agent for natural rubber latex. A formula of the biological curing agent comprises the following components in parts by weight: 0.5-2.0 parts of water, 8-10 parts of glacial acetic acid, 0.3-0.7 part of citric acid and 0.009-0.02 part of carbocisteine. The biological curing agent is prepared by the following steps of: after the components are compounded into the formula, adding 500-800 parts of natural rubber latex, fully stirring to be uniform and curing. The biological curing agent has the beneficial effects that not only are no toxicity and harm caused, but also the environment is not polluted, the molecular structure of the rubber is not damaged, and the quality and the dry content of the natural rubber latex are improved; and the use is convenient and the cost is reduced.

The invention discloses a dry powder inhalation preparation of an expectorant and a preparation method of the dry powder inhalation preparation, and belongs to the technical field of dry powder inhalation preparations. The dry powder inhalation preparation comprises the following raw materials of an active drug component, a carrier and an auxiliary material, wherein the mass percentage of the active drug component in the total amount is 0.1%-99.9%, the mass percentage of the carrier in the total amount is 0%-99.9%, and the mass percentage of the auxiliary material in the total amount of the raw materials is 0%-10%; the active drug component is one or two of ammonium chloride, potassium iodide, bromhexine, ambroxol, acetylcysteine, carbocisteine and tiloxpol; the carrier is lactose; and the auxiliary material is one or more of magnesium stearate, phospholipid, leucine and lysine. The prepared dry powder inhalation preparation of the expectorant can effectively improve the secretion amount of phenol red in the trachea of mice.

The invention relates to the technical field of soluble granules and particularly relates to granules for eliminating phlegm and stopping cough and a preparation method thereof. The granules for eliminating phlegm and stopping cough comprise 40-50 parts by weight of carbocisteine, 80 to 160 parts by weight of loquat leaf dry extract, 100 to 120 parts by weight of saccharose, 1 to 5 parts by weightof citric acid, 0.5 to 1 part by weight of saccharin sodium salt and 0 to 10 parts by weight of additive aids. Through combination of the traditional Chinese medicine loquat leaf dry paste and the western medicine carbocisteine, the acute exacerbation of chronic obstructive pulmonary disease is effectively reduced. The granules have good effects of treating thick sputum, expectoration or dyspneacaused by bronchitis and bronchial asthma, can reduce the acute exacerbation of chronic obstructive pulmonary disease and are suitable for people with high incidence of respiratory infection.

The invention discloses a method and system for recovering waste water generated in carbocisteine production. The system comprises a bipolar membrane electro-dialysis desalination system and a recovering system; the recovering system comprises an acid concentrating and recovering system, a base concentrating and recovering system and a carbocisteine concentrating and recovering system. With the adoption of the system, salts in the waste water generated in carbocisteine production can be converted into corresponding acid and base so as to be removed; the obtained acid and base can be directly used in the carbocisteine production process or be used in the carbocisteine production process after an advanced treatment; the carbocisteine in the waste water is further recovered by using a carbocisteine concentrating crystallizing system. By treating the waste water generated in the carbocisteine production by using the method, organism pollution, salt pollution and ammonia nitrogen pollution are avoided; in addition, the recovered acid and base can be reused in the carbocisteine production process to realize zero emission; by using the recovered carbocisteine, the carbocisteine yield is increased and the cost of the method provided by the invention can be further reduced.

The invention belongs to the technical field of medicine, and particularly relates to a carbocisteine oral solution and preparation thereof, the carbocisteine oral solution comprises 2-3% of carbocisteine, 5-10% of pregelatinized starch, 5-20% of saccharin sodium salt, 1-3% of sodium hydroxide and 0.2-0.3% of preservative, and the preservative is sodium methyl p-hydroxybenzoate. The carbocisteine oral solution provided by the invention has better long-term stability and good taste, the pregelatinized starch increases the taste and the solubility of the carbocisteine oral solution to prevent insoluble raw materials from being separated out, the oral solution is still stable and clear after being stored for 36 months at room temperature, the content of effective components is reduced by only 0.1-0.3%, and the oral solution is suitable for oral administration. Compared with the prior art, remarkable progress is achieved.