34 results about "Carbocisteine" patented technology

The invention discloses a preparation method and an application of an erythrocyte membrane-coated acid-sensitive polymer prodrug nano drug delivery system, wherein the polymer is formed by connecting sodium polyglutamate and carbocisteine through a peptide bond and then is bonded with an anti-cancer drug taxol to form the polymer prodrug; and the polymer prodrug is coated by an erythrocyte membrane to obtain an erythrocyte membrane-coated acid-sensitive polymer drug delivery system. The drug delivery system has the following characteristics that the particle size is about 100nm, and the shape is a sphere; the drug delivery system is relatively stable in a phosphate buffer and serum; the drug release character is relatively good in an acid environment; the toxicity is obviously reduced in cell experiments; the ingestion of the system by macrophage is obviously reduced; without destructive effect on erythrocyte, the system can be applied to intravenous injection; the circulating time of the system in blood is remarkably longer than that of polymer; and the system has an obvious inhibiting effect on the tumor growth of lung cancer.

The invention relates to a carbocisteine oral liquid and a preparation method thereof. The oral liquid comprises carbocisteine accounting for 2% to 10% of the oral liquid, sodium hydroxide, an antioxidant, a solution stabilizer composition, and a flavoring agent, and has a pH value of 6.0 to 7.5. The oral liquid is prepared by the following steps: carrying out salt-forming reactions between carbocisteine and a sodium hydroxide solution, then dissolving the salts into water, adding an antioxidant, a solution stabilizer composition, and a flavoring agent, stirring, adding water to a metered volume, filtering, filling the solution into cans, and finally sterilizing the cans so as to obtain the oral liquid; wherein each can contains 10 to 120 mL of oral liquid. The oral liquid is widely used to treat thick phlegm or dys-expectoration caused by chronic bronchitis, bronchus asthma, and the like, and has the characteristics of stable property, long shelf life, and safer clinical application.

The invention relates to a synthetic method of carbocisteine, wherein a two-pot reaction process in the prior art is changed into a one-pot reaction process, thereby simplifying the process and reducing devices. A low-temperature nitrogen protective process is changed into a normal-temperature nitrogen-free protective process, thereby reducing material and energy consumptions. A two-step crystallization process is changed into a one-step crystallization process, thereby reducing processes and devices and increasing the yield.

The invention discloses a medicinal composition of carbocisteine and treatment effects of the medicinal composition for leukemia. The medicinal composition of carbocisteine provided by the invention contains carbocisteine and a natural product compound (I) which is obtained by separating the dried folium pyrrosiae and has the novel structure, when carbocisteine and the natural product act independently, certain treatment effect can be achieved on leukemia, when carbocisteine and the natural product are mixed for use, the treatment effect for leukemia is more obvious, the medicinal composition can be developed into the medicine for treating leukemia, and compared with the prior art, the medicinal composition has outstanding substantive features and obvious progress.

The invention relates to a production process for a carbocisteine buccal tablet. The production process comprises the following steps: crushing and sieving of raw and accessory materials; weighing and batching; mixing and granulating; drying; size stabilization; total blending; tableting; packaging; and warehousing. The carbocisteine buccal tablet produced in the invention is used for cough and difficult expectoration caused by chronic bronchitis and bronchial asthma mucus; in the production process of the carbocisteine buccal tablet, crushing granularity of the main material--carbocisteine is strictly controlled so as to ensure that all the main material is crushed and sieved with a 100-mesh sieve, and control of raw material granularity provides prerequisites for rapid absorption of the carbocisteine buccal tablet; and a high-grade material of the industry is a binder, so the appearance of the tablet surface is beautiful and rapid arrival of a drug at a designated position can be promoted.

The invention relates to a carbocisteine buccal tablet. The carbocisteine buccal tablet is prepared from the following raw materials by weight: 15.014 to 15.563 parts of carbocisteine, 0.319 to 0.449 part of borneol, 0.0018 to 0.003 part of menthol, 0.004 to 0.005 part of aspartame, 54.470 to 56.544 parts of sucrose, 25.738 to 26.196 parts of mannitol, 0.479 to 0.598 part of PVPK 30, 0.958 to 2.394 parts of magnesium stearate, 0.006 to 0.021 part of lake and 0.035 to 0.048 of essence. The buccal tablet provided by the invention is used for cough and difficult expectoration caused by chronic bronchitis and bronchial asthma mucus, takes effect rapidly and has occasional or slight side effects (like dizziness, belching, nausea; and compared with a general dosage form, the carbocisteine buccal tablet provided by the invention does not need to be taken with water and is placed in an oral cavity, and the drug in the tablet is slowly dissolved and produces long-lasting and local effect.

The invention relates to carbocisteine syrup with improved water solubility and a preparation method of the carbocisteine syrup. The method comprises the following steps: weighing syrup substrate, adding an appropriate amount of purified water into the syrup substrate, carrying out complete boiling so that the syrup substrate is dissolved, carrying out filtering, carrying out standing for cooling till the temperature is 40-60 DEG C, and carrying out shaking till the product is uniform, thus obtaining simple syrup; weighing an active pharmaceutical ingredient, namely, carbocisteine, adding carbocisteine into an appropriate amount of water, slowly adding with an appropriate amount of sodium hydroxide solution under stirring, so that carbocisteine is completely dissolved (alkali is added according to the molar ratio of 1 to 1 for forming salt), adding with an appropriate amount of a preservative and an appropriate amount of a corrigent, and carrying out sufficient stirring; adding the carbocisteine solution into the simple syrup; enabling the relative density of the liquid medicine to be 1.08-1.25; adding with an appropriate amount of boiling water, carrying out stirring till the uniform state is reached, and carrying out filtering after the assay was approved after the liquid medicine is cooled to be 50 DEG C or below, and thus obtaining the filtrate, which is the syrup capable of relieving cough and eliminating phlegm. The method provided by the invention is simple in process and low in cost, the obtained carbocisteine syrup is good in water solubility, the method is suitable for industrial production, and thus the difficulties that carbocisteine has difficulty in dissolving in water, and the bioavailability is low are solved.

A pharmaceutical composition for respiratory system disease and the preparation process therefor, consisting of levodropropizine and carbocisteine as active ingredients with a pharmaceutically acceptable excipient. The present pharmaceutical composition has a marked cough-relieving effect and fewer negative reactions.

The invention provides a carbocisteine ​​oral solution and a preparation method thereof, relating to the technical field of medicine, comprising carbocisteine, glycerin, lemon juice, loquat, antioxidant, solution stabilizer, flavoring agent, and pH regulator; The method comprises the following steps: (1) taking the glycerin, lemon juice and loquat dew of the formula quantity, adding ultrapure water, and ultrasonic treatment for 10-12min; (2) adding the carbocisteine ​​of the formula quantity into the solution in step (1) , heated to boiling, then stirred, and mixed evenly; (3) adding antioxidant, solution stabilizer, flavoring agent in boiling state, keeping boiling for 5‑8min, standing, and cooling to room temperature; (4) adding pH adjustment medicament, stir evenly, make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral solution. The method of the invention has simple process and low cost, and the obtained carbocisteine ​​oral solution has good water solubility and is easy to industrialized production, and solves the problems of carbocisteine ​​taste discomfort and low bioavailability.

The invention discloses a method for separating and determining carbocisteine and impurities thereof by high performance liquid chromatography. The determination method adopts a chromatographic column taking octadecylsilane chemically bonded silica as a filler, and the detection conditions are as follows: chromatographic conditions: the chromatographic column is an octadecylsilane chemically bonded silica chromatographic column, a mobile phase is a phosphate-ion pair buffer solution, the pH value of the mobile phase is 1.6-2.0, and the detection wavelength is 215 nm. The method disclosed by the invention is high in precision, good in repeatability and high in recovery rate, and can be widely applied to quality detection of carbocisteine raw material medicines from different sources and corresponding preparations thereof.

The invention discloses a dry powder inhalation preparation of an expectorant and a preparation method of the dry powder inhalation preparation, and belongs to the technical field of dry powder inhalation preparations. The dry powder inhalation preparation comprises the following raw materials of an active drug component, a carrier and an auxiliary material, wherein the mass percentage of the active drug component in the total amount is 0.1%-99.9%, the mass percentage of the carrier in the total amount is 0%-99.9%, and the mass percentage of the auxiliary material in the total amount of the raw materials is 0%-10%; the active drug component is one or two of ammonium chloride, potassium iodide, bromhexine, ambroxol, acetylcysteine, carbocisteine and tiloxpol; the carrier is lactose; and the auxiliary material is one or more of magnesium stearate, phospholipid, leucine and lysine. The prepared dry powder inhalation preparation of the expectorant can effectively improve the secretion amount of phenol red in the trachea of mice.

The invention discloses a method and system for recovering waste water generated in carbocisteine production. The system comprises a bipolar membrane electro-dialysis desalination system and a recovering system; the recovering system comprises an acid concentrating and recovering system, a base concentrating and recovering system and a carbocisteine concentrating and recovering system. With the adoption of the system, salts in the waste water generated in carbocisteine production can be converted into corresponding acid and base so as to be removed; the obtained acid and base can be directly used in the carbocisteine production process or be used in the carbocisteine production process after an advanced treatment; the carbocisteine in the waste water is further recovered by using a carbocisteine concentrating crystallizing system. By treating the waste water generated in the carbocisteine production by using the method, organism pollution, salt pollution and ammonia nitrogen pollution are avoided; in addition, the recovered acid and base can be reused in the carbocisteine production process to realize zero emission; by using the recovered carbocisteine, the carbocisteine yield is increased and the cost of the method provided by the invention can be further reduced.

The invention belongs to the technical field of medicine, and particularly relates to a carbocisteine oral solution and preparation thereof, the carbocisteine oral solution comprises 2-3% of carbocisteine, 5-10% of pregelatinized starch, 5-20% of saccharin sodium salt, 1-3% of sodium hydroxide and 0.2-0.3% of preservative, and the preservative is sodium methyl p-hydroxybenzoate. The carbocisteine oral solution provided by the invention has better long-term stability and good taste, the pregelatinized starch increases the taste and the solubility of the carbocisteine oral solution to prevent insoluble raw materials from being separated out, the oral solution is still stable and clear after being stored for 36 months at room temperature, the content of effective components is reduced by only 0.1-0.3%, and the oral solution is suitable for oral administration. Compared with the prior art, remarkable progress is achieved.