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Production process for carbocisteine buccal tablet

A production process, the technology of carbocisteine, which is applied in the field of medicine, can solve problems such as troublesome taking, difficult to cover up the bad taste of drugs, etc., and achieve a one-sided and beautiful effect

Inactive Publication Date: 2015-11-04
临汾奇林药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The cough-relieving and phlegm-reducing drugs currently on the market are mainly common solid preparations (such as granules, capsules) and liquid solutions, which are troublesome to take and difficult to mask the bad taste of the medicine

Method used

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  • Production process for carbocisteine buccal tablet

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A carbocisteine ​​buccal unit production process, comprising the following steps

[0023] a. Crushing and sieving the raw and auxiliary materials, the fineness is 80 mesh of mannitol, 100 mesh of magnesium stearate, 60 mesh of menthol, 60 mesh of borneol, 80 mesh of PVPK, 100 mesh of sucrose, 100 mesh of protein sugar, and 100 mesh of carbocisteine;

[0024] b. Weighing and ingredients, carbocisteine ​​4.70 kg, mannitol 8.60 kg, sucrose 17.70 kg, color lake 0.007 kg, essence 0.011 kg, borneol 0.15 kg, take 0.20 kg of PVPK30 and 0.9 kg of purified water in the formula amount, stir after soaking Uniform, fast mixing for dry mixing;

[0025] c. Mix and granulate, add the prepared materials into the wet mixing granulator and dry mix for 3 minutes, add the prepared binder into the wet mixing granulator, wet mix quickly and wet mix for 1 minute, Add the wet-mixed material to a swinging granulator equipped with a 16-mesh nylon screen for granulation;

[0026] d. Drying, ...

Embodiment 2

[0033] A carbocisteine ​​buccal unit production process, comprising the following steps

[0034] a. Crushing and sieving the raw and auxiliary materials, the fineness is 80 mesh of mannitol, 100 mesh of magnesium stearate, 60 mesh of menthol, 60 mesh of borneol, 80 mesh of PVPK, 100 mesh of sucrose, 100 mesh of protein sugar, and 100 mesh of carbocisteine;

[0035] b. Weighing and ingredients, carbocisteine ​​5.20 kg, mannitol 8.20 kg, sucrose 18.20 kg, color lake 0.002 kg, essence 0.016 kg, borneol 0.10 kg, take 0.15 kg of PVPK30 and 0.9 kg of purified water in the formula amount, stir after soaking Uniform, fast mixing for dry mixing;

[0036] c. Mix and granulate, add the prepared materials into the wet mixing granulator and dry mix for 3 minutes, add the prepared binder into the wet mixing granulator, wet mix quickly and wet mix for 1 minute, Add the wet-mixed material to a swinging granulator equipped with a 16-mesh nylon screen for granulation;

[0037] d. Drying, ...

Embodiment 3

[0044] A carbocisteine ​​buccal unit production process, comprising the following steps

[0045] a. Crushing and sieving the raw and auxiliary materials, the fineness is 80 mesh of mannitol, 100 mesh of magnesium stearate, 60 mesh of menthol, 60 mesh of borneol, 80 mesh of PVPK, 100 mesh of sucrose, 100 mesh of protein sugar, and 100 mesh of carbocisteine;

[0046] b. Weighing and ingredients, carbocisteine ​​4.90 kg, mannitol 8.40 kg, sucrose 18.00 kg, color lake 0.004kg, essence 0.013 kg, borneol 0.13g, take 0.17 kg of PVPK30 and 0.9 kg of purified water in the formula amount, stir after soaking Uniform, fast mixing for dry mixing;

[0047] c. Mix and granulate, add the prepared materials into the wet mixing granulator and dry mix for 3 minutes, add the prepared binder into the wet mixing granulator, wet mix quickly and wet mix for 1 minute, Add the wet-mixed material to a swinging granulator equipped with a 16-mesh nylon screen for granulation;

[0048] d. Drying, the...

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Abstract

The invention relates to a production process for a carbocisteine buccal tablet. The production process comprises the following steps: crushing and sieving of raw and accessory materials; weighing and batching; mixing and granulating; drying; size stabilization; total blending; tableting; packaging; and warehousing. The carbocisteine buccal tablet produced in the invention is used for cough and difficult expectoration caused by chronic bronchitis and bronchial asthma mucus; in the production process of the carbocisteine buccal tablet, crushing granularity of the main material--carbocisteine is strictly controlled so as to ensure that all the main material is crushed and sieved with a 100-mesh sieve, and control of raw material granularity provides prerequisites for rapid absorption of the carbocisteine buccal tablet; and a high-grade material of the industry is a binder, so the appearance of the tablet surface is beautiful and rapid arrival of a drug at a designated position can be promoted.

Description

technical field [0001] The invention relates to a production process of carbocisteine ​​buccal tablets, which belongs to the technical field of medicine. Background technique [0002] According to media reports: Among the deaths caused by various diseases in my country, the deaths caused by respiratory diseases occupy the first place, and the number is still increasing year by year. in the process of urbanization. The environment is deteriorating day by day. In addition to industrial pollution, harmful gases emitted by motor vehicles, air conditioners, refrigerators, road asphalt, paint, etc. seriously threaten our respiratory health. [0003] The cough-relieving and phlegm-reducing drugs currently on the market are mainly common solid preparations (such as granules, capsules) and liquid solutions, which are cumbersome to take and difficult to mask the bad taste of the medicines. Contents of the invention [0004] The invention overcomes the deficiencies of the prior art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/198A61P11/10
Inventor 翟志喜
Owner 临汾奇林药业有限公司
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