The invention relates to health-care multi-functional lotion and a preparation method thereof, and relates to the technological field of detergent, sterilizing agent, disinfectant and pharmaceutical preparation. The invention is preparation made according to the following weight portions: 3 portions to 5 portions of fatty alcohol, 0.5 portions to 2 portions of lemon, 0.3 portions to 2 portions of soda, 85 portions to 95 portions of purified water, 0.5 portion to 2 portions of soap powder, and 1.5 portions to 3 portions of salt. The method only requires the respective dissolution and direct mixing of the materials. The invention has significant effects; the invention not only can significantly remove pesticide residue in fruits and vegetables and decontaminate, but also has better health-care functions of sterilization, microbial inhibition, disinfection, anti-inflammation, pain easing, itch prevention, promotion of blood circulation, promotion of menstruation, activation and other functions for human bodies through external washing (or oral taking); the invention has better health-care and adjuvant therapeutic effects for treatment of various types of inflammation, bacteria, virus and other diseases; and the invention has beautifying and slimming effects. The formula is unique and scientific; the preparation method is simple and easy; the cost is low and economic; and the social benefits are good.