The invention discloses a method for preparing a marine environment-friendly
calcium citrate
hard tissue repair material. The method comprises the following steps of: (1) cleaning fresh
oyster shells in a non-
pollution sea area physicochemically, soaking the cleaned fresh
oyster shells in weak acid, and washing by flowing water until impurities are removed completely; (2) crushing the clean
oyster shells into granules by a ball
grinding mill, and sieving with a 200-mesh
sieve; (3) reacting oyster shell
powder with a supersaturated solution of
citric acid, centrifuging, taking precipitates out, and
drying by a forced draft
drying machine to obtain
calcium citrate
powder; and (4) filtering the prepared
calcium citrate
powder by using a 100-mesh filter
sieve, filtering by using a 60-mesh filter
sieve, and taking filtered substances out to obtain calcium citrate granules. The marine environment-friendly calcium citrate
hard tissue repair material has high
mechanical strength and appropriate granular sizes, and the degradation time of the material is prolonged by tight bonding force among crystals, so that the material can be degraded slowly in bodies, and calcium ions are released stably to create a local high-calcium environment; and the marine environment-friendly calcium citrate
hard tissue repair material has an obvious
therapeutic effect on bone loss,
osteoporosis and bone tumors, and has a wide application value in
biological tissue repair.