142results about How to "Small hindrance" patented technology

In a method of assembling a surface illumination system having an electromagnetic radiation emitting front side, at least one primary radiation source suitable for emitting electromagnetic radiation when operating is disposed on at least one mounting area of a flexible carrier. The flexible carrier has a front side and a back side opposite said front side, the front side of the flexible carrier defines a reference plane. The mounting area of the flexible carrier on which the primary radiation source is disposed is then bent out of the reference plane such that an optical axis of the primary radiation source extends parallel or obliquely to the reference plane. In a further step, at least one light-conducting guide having a radiation emitting front side and at least one incoupling region is disposed on the flexible printed circuit board so that in operation, the primary radiation source emits radiation into the incoupling region of the light guide and the radiation emitting front side of the light guide points in the direction of the radiation emitting front side of the surface illumination system. A corresponding surface illumination system is also described.

A heat-generating element includes at least one PTC heating element, strip conductors lying flat on it on both sides, and a frame which forms at least one frame opening for holding the at least one PTC heating element. The frame, as a part of a housing, forms a structural unit with a wedge element having a first wedge surface that extends parallel to the strip conductor and a second wedge surface that lies exposed on the exterior side of the housing and that is aligned diagonally to the first wedge surface. For fixing the heat-generating element precisely in place in a slot in the housing, the heat-generating element has spacing surfaces positioned upstream or downstream of the at least one PTC heating element in the direction of the length of the slot. Also provided is a method of manufacturing an electric heating device.

The invention provides a probe based on a G-quadruplex-chlorine heme DNA enzyme and a method for detecting protein. The method for detecting the protein facilitates detecting operation and is low in cost and free of marking. The probe has the advantages of being high in sensitivity and low in background noise. When the protein is detected, the detecting operation is easy, consumed time is short, cost is low, and the problems that a method for detecting the protein in the prior art is long in consumed time, high in cost and complex in detecting probe manufacturing are solved.

A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

The invention discloses a over-branched big monomer: poly-fat type and (fat-amide) type over-branched big monomer through new pattern molecule designing, which is characterized by the following: adopting step-by-step extensions through many method such as infrared, GPC, acid value and hydroxyl value detection; applying the two over-branched big monomer to compounding acroleic acid pitch; preparing acroleic acid pitch with super high graft degree structure, lower viscosity.

The invention discloses a composite ceramic membrane for lithium ion batteries and a preparation method thereof, including a ceramic coating modification method and a ceramic lithium battery membrane. The ceramic protective layer is mainly prepared from a ceramic-adhesive mixture subjected to graft modification by a sodium-sulfonate / sodium-carboxylate-group-containing anionic surfactant. The grafting is completed by using a grafting-on process under the action of a coupling agent; the grafting ratio of the ceramic is higher; the high-temperature-resistant large-surface-area nano ceramic is introduced to the conventional PP (polypropylene) membrane surface, the insulativity and electrolyte wettability of the modified ceramic membrane are greatly enhanced; and the membrane has excellent high-temperature heat stability especially at the high temperature of 130 DEG C, 150 DEG C and 180 DEG C. The lithium battery composite membrane avoids the thermal shrinkage of the convention membrane, thereby avoids the thermorunaway in the battery due to thermal shrinkage, and further enhancing the safe reliability of the lithium ion battery.

The invention discloses a block conjugated polymer, a preparation method thereof and use thereof. The structural general formula of the block conjugated polymer is represented by a formula I. In the invention, diazosulfide serving as a receptor is subjected to side-group modification, the obtained block conjugated polymer is improved in dissolubility and crystallinity and reduced in steric hindrance of the alkyl chains, and thus high organic solar cell efficiency is achieved. Therefore, the block conjugated polymer provided by the invention has a promising application prospect in solar cells.

A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

The invention discloses a method for separating and enriching micro circulating tumor cells (circulating tumor cells, CTCs) in whole blood for further providing a basis for subsequent study of tumor cells, and relates to the biomedical field. The method comprises the following steps of: covalent coupling of dendrimers and matters (special matters) specifically combined with target cells; further coating long-chain biotin molecules by dendrimers modified by the specific matters; capturing CTCs in a whole blood sample by dendrimers co-modified by the special matters and the long-chain biotin; identifying and coupling long-chain biotin dendrimers in the whole blood by streptavidin modified nanomagnetic beads; and separating and resuspending the captured CTCs. The resuspension can be directly used for subsequent analysis. Compared with conventional cell separation methods, the method is more suitable for magnetic separation of CTCs in complex whole blood samples, so that the magnetic separation time is shortened, and the CTCs separation efficiency in the whole blood sample is improved.

A refrigeration cabinet, in particular a commercial refrigerator or freezer, is provided. The refrigeration cabinet has a housing, which has a front access opening, a door, which has at least one door leaf, for the access opening, and a guide. The door leaf has a height and a width and is mounted such that it can be rotated about a vertical rotation axis and can be displaced transverse to the rotation axis. The guide defines a movement of the door leaf between a closed position and an open position in such a way that the pivot region of the door leaf projects less than a full door-leaf width into the exterior in front of the access opening, and that the door leaf is mounted such that it can be rotated about a vertical axis and can be displaced transverse to the rotation axis.

A heat-generating element includes at least one PTC heating element, strip conductors lying flat on it on both sides, and a frame which forms at least one frame opening for holding the at least one PTC heating element. The frame, as a part of a housing, forms a structural unit with a wedge element having a first wedge surface that extends parallel to the strip conductor and a second wedge surface that lies exposed on the exterior side of the housing and that is aligned diagonally to the first wedge surface. For fixing the heat-generating element precisely in place in a slot in the housing, the heat-generating element has spacing surfaces positioned upstream or downstream of the at least one PTC heating element in the direction of the length of the slot. Also provided is a method of manufacturing an electric heating device.

An operating device with an operating piece, which may be positioned near the floor, includes at least one operating element for controlling a medical instrument. Operation of the medical instrument is possible by actuation of the at least one operating element by foot, such that the operator has hands free to use for further manipulation. A flexible positioning of the operating piece in a defined movement range is possible by arrangement of the operating device such as to be pivotable and / or extendable / retractable relative to the medical instrument which is good for operational manipulation. The operational device may be used during operation of a mammography device.

The invention relates to a method for synthesizing Sulfentrazone. The method is characterized by comprising the steps of liberating o-chlorophenylhydrazine from o-chlorophenylhydrazine hydrochloride, which serves as a raw material, by an alkali, subjecting o-chlorophenylhydrazine to a reaction with trimethyl orthoacetate and potassium cyanate so as to obtain 1-o-chlorophenyl-3-methyl-1H-1,2,4-triazol-5-one, and then, subjecting 1-o-chlorophenyl-3-methyl-1H-1,2,4-triazol-5-one to N-alkylation, chlorination, nitration, reduction and sulfonylation, thereby obtaining the Sulfentrazone, wherein a composite catalyst and a solvent, i.e., dichloroethane are adopted in a chlorination reaction. The method for synthesizing the Sulfentrazone, disclosed by the invention, has the advantages that the o-chlorophenylhydrazine hydrochloride serves as the raw material, so that the steric hindrance of an intermediate product can be low, and the yield of the product is increased; and meanwhile, in the chlorination reaction, the composite catalyst is adopted, thus, the orientation effect on all atoms is good, and the solvent is dichloroethane, so that the recycling of the solvent is facilitated.

The invention belongs to the technical field of resin for coatings, particularly relates to excellent boiling-resistant and neutral-salt-mist-resistant polyester resin for a TGIC system low-temperature curing type powder coating, and further relates to a preparation method of the polyester resin. The excellent boiling-resistant and neutral-salt-mist-resistant polyester resin for the TGIC system low-temperature curing type powder coating is mainly prepared from the following raw materials in parts by mole through a polymerization reaction: 8-20 parts of terephthalic acid, 12-25 parts of dodecenyl succinic anhydride, 6-15 parts of isophthalic acid, 12-28 parts of 1H, 1H, 12H, 12H-perfluoro-1,12- dodecanediol, 7-18 parts of neopentyl glycol, 8-20 parts of 2, 2, 3, 3-tetrafluoro-1, 4-butanediol and 5-10 parts of 2, 2-difluoromalonic acid. The TGIC system powder coating finally prepared by the product disclosed by the invention can realize 150 DEG C / 15min low-temperature curing film formation, the coating quality meets the requirements of a powder coating film, and the coating film has outstanding boiling resistance and neutral salt mist resistance.

The invention discloses an ultrafast-response overcharge-prevention electrochromic device and a preparation method thereof. The ultrafast-response overcharge-prevention electrochromic device comprisesa first transparent electrode, an ionic conduction layer, an organic electrochromic layer, an inorganic electrochromic layer and a second transparent electrode which are arranged in a sequentially laminated way. The ultrafast-response overcharge-prevention electrochromic device has the following beneficial effects that (1) the ionic conduction layer has the great pore diameter and is provided with many pore passages and facilitates positive ion transmission, so that the response speed of the device is accelerated; (2) the cooperative action of a plurality of positive ions is realized in the electrochromic process of the electrochromic device, so that the device has very high regulation capability; (3) in the ultrafast-response overcharge-prevention electrochromic device, a resin layer perse has good insulation capability, so that the electricity leakage can be prevented without adding an electron blocking layer; and (4) the wetting performance of a solid-liquid interface is better than that of solid-solid interface contact, so that the steric hindrance between interfaces is reduced, and the very high coloring efficiency is realized.

To provide such a base multiplying agent capable of being used for crosslinking reaction, for example of a epoxy compound and the like, that generates another base by action of a base, and can efficiently perform base multiplying reaction, and a base-reactive curable composition using the base multiplying agent.The base generating agent of the invention is represented by the following formula (1):(In the formula (1), X represents a hydrogen atom, a substituted alkyl group or an unsubstituted alkyl group; Y represents a substituted or unsubstituted alkylene chain; and n represents an integer of from 1 to 4.)

The invention discloses a monofunctional branched polyethyleneglycol. The general formula of the monofunctional branched polyethyleneglycol is disclosed as Formula (1), wherein X1 and X2 are respectively an alkyl group with 1-20 carbon atoms; n1 and n2 are respectively a whole number ranging from 1 to 1000; n3 is a whole number ranging from 11 to 1000; L1 and L2 are respectively a linking group capable of existing stably under illumination, enzyme, acidic or alkaline conditions; p is 0 or 1; R1 is a hydrogen atom or alkyl group with 1-20 carbon atoms; and R is a functional group. The monofunctional branched polyethyleneglycol overcomes the defects of traditional multiarm polyethyleneglycol in drug modification application, can modify biologically relevant substances under mild conditions, and has the advantages of high modification rate, fewer byproducts, high activity retentivity and the like.

The invention discloses a method for directly separating CD<4+> and CD<8+> lymphocytes, lays a better foundation for the subsequent research on the CD<4+> and CD<8+> lymphocytes, and relates to the field of biomedicines. The method comprises steps of: multi-arm well and star-shaped polymer and mouse anti-human CD<4+> or CD<8+> monoclonal antibody covalent coupling, long-chain biotin molecule coating through utilizing a mouse anti-human CD<4+> or CD<8+> monoclonal antibody-modified multi-arm well and star-shaped polymer, peripheral blood sample CD<4+> and CD<8+> lymphocyte acquiring through utilizing a mouse anti-human CD<4+> or CD<8+> monoclonal antibody and long-chain biotin co-modified multi-arm well and star-shaped polymer, peripheral blood long-chain biotinylation multi-arm well and star-shaped polymer identifying and coupling through utilizing streptavidin-modified nano magnetic beads, captured CD<4+> and CD<8+> lymphocyte separating and suspending and the like. A suspension can be directly used for subsequent analysis; and compared with a conventional cell separating method, the method is suitable for magnetically separating complicated peripheral blood sample CD<4+> and CD<8+> lymphocytes, so that the peripheral blood sample CD<4+> and CD<8+> lymphocyte separation efficiency is increased.

An operating device with an operating piece, which may be positioned near the floor, includes at least one operating element for controlling a medical instrument. Operation of the medical instrument is possible by actuation of the at least one operating element by foot, such that the operator has hands free to use for further manipulation. A flexible positioning of the operating piece in a defined movement range is possible by arrangement of the operating device such as to be pivotable and / or extendable / retractable relative to the medical instrument which is good for operational manipulation. The operational device may be used during operation of a mammography device.

The invention discloses a preparation method of a naphthalene sulfonate-alkyl naphthalene sulfonate-formaldehyde condensate. The preparation method comprises the following steps: firstly enabling naphthalene and an alkylation reagent to generate a mixed solution of naphthalene and alkyl naphthalene under the catalysis of sulfuric acid; then adding sulfuric acid into the mixed solution of naphthalene and alkyl naphthalene, and performing the sulfonation reaction; and adding formaldehyde, performing the one-pot condensation, and preparing thea naphthalene sulfonate-alkyl naphthalene sulfonate-formaldehyde condensate. By adopting the preparation method, the naphthalenesulfonic acid and alkyl naphthalene sulfonate do not need to be prepared independently, and the operation is simple; the wasteacid does not need to be removed, no acidic waste water is produced, and safety and environmental protection can be realized; and the prepared naphthalene sulfonate-alkyl naphthalene sulfonate-formaldehyde condensate is used as a dispersing agent to be applied to pesticide water dispersion granules or suspension, and has higher suspension rate and better heat storage stability.

The invention relates to the technical field of biosensors and discloses an estriol hapten and antibody and the application thereof in a fast sensor method for uncojugated estriol detection. The structure of the hapten is scientifically designed, so that sensitivity and specificity of the antigen-antibody are improved; electro-deposition of a prussian blue-chitosan-nanogold composite membrane on the surface of an electrode is conducted, the estriol antigen is fixed to the surface of the membrane, a novel horse radish peroxidase labeled estriol antibody and a sample to be tested are added after an unbound site is sealed, the sample and a fixed antigen compete for a free enzyme labeled antibody, hydrogen peroxide is added after washing, a current signal is measured, a cyclic voltammetry estriol standard curve is obtained, the fast sensor method for uncojugated estriol detection is provided successfully, detection range is 0.001-100 ng / mL, and detection limit is 0.001 ng / mL. The method has the advantages of being easy to operate, high in sensitivity, quick, convenient and the like and can be well applied to ultra-sensitive and fast detection of estriol in the sample.

The invention discloses a highly connected coordination polymer and a preparation method thereof. The highly connected coordination polymer adopts the following chemical formula: [Zn5(3,3'-tmbpt)(btec)2(OH)2], wherein betc is deprotonated 1,2,4,5-pyromellitic acid; 3,3'-tmbpt is 1-((1H-1,2,4-triazole)methyl)-3,5-bis(3-pyridyl)-1,2,4-triazole. Carboxyl groups of polycarboxylic acid anions can coordinate with metal ions to form metal clusters with larger size; the metal clusters serve as nodes, so that connections of the nodes can be greatly increased. In addition, distances among several coordinating groups of a polydentate nitrogen-containing ligand 3,3'-tmbpt is relatively large, so that steric hindrance is relatively small during coordination, and the metal clusters can further expand easily to form the coordination polymer adopting highly connected structure. The coordination polymer can serve as a broadband semiconductor material and a molecular-based light emitting material to be further developed and applied.

The present invention discloses a conjugated block polymer, and its preparation method and application. The conjugated block polymer has a structure shown in a formula I, wherein X represents S, -NH, CH2, O or -CH=CH-; each of R1 and R2 is a substituent group which is hydrogen atom, saturated alkane, double-bond alkane, triple-bond alkane, ether chain, alkyl-chain amine or sulfydryl; and n is numbers of structure-repeated units of the main polymer chain, and is a positive integer larger than 0. Through changing the polymer structure, the polymer has improved spectrum, increased molecular weight and dissolubility, reduced steric hindrance and improved crystallization property by adjusting different conjugated units, and has wide application prospect on photoelectric functional devices, particularly on polymer solar cells.

The electrocatalytic compositions of this invention comprise a platinum-based electrocatalyst and polyvinylpyrrolidone (PVP), whereby the PVP improves certain properties of the platinum-based electrocatalyst. The electrolytic compositions described herein have applications in fuel cell technologies. The polymer-modified platinum-based electrocatalyst compositions exhibit an enhanced long-term CO tolerance with a small hindrance to the intrinsic activity of the platinum based electrocatalyst. Furthermore, the electrocatalytic compositions demonstrate improved catalyst stability.

To provide such a base multiplying agent capable of being used for crosslinking reaction, for example of a epoxy compound and the like, that generates another base by action of a base, and can efficiently perform base multiplying reaction, and a base-reactive curable composition using the base multiplying agent.The base generating agent of the invention is represented by the following formula (1):(In the formula (1), X represents a hydrogen atom, a substituted alkyl group or an unsubstituted alkyl group; Y represents a substituted or unsubstituted alkylene chain; and n represents an integer of from 1 to 4.)

The invention discloses acrylate resin containing a hyperbranched structure and a preparation method thereof. Two kinds of hyperbranched macromonomers, namely a polyester type hyperbranched macromonomer and a poly(ester-amide) type hyperbranched macromonomer, with internal double bonds and external reactive functional groups such as hydroxyl groups and carboxyl groups are synthesized by a stepwiseexpansion method. The hyperbranched macromers and a synthesis process thereof are characterized by an infrared measurement method, a GPC measurement method, an acid value measurement method and a hydroxyl number measurement method and other methods. The synthesized two hyperbranched macromonomers are applied to synthesis of acrylic resin, and the acrylate resin with an ultra-high branching structure and lower viscosity is prepared. The resin can be used for preparing high-solid-content self-drying coatings, high-solid-content baking coatings and high-solid-content two-component room temperature curing coatings and used as adhesives. The organic solvent content of the acrylate resin during production and use can be effectively reduced, the pollution to the environment can be reduced, and the performance is excellent.

The invention provides schizophyllan modified sodium hyaluronate microsphere gel, a preparation method of the sodium hyaluronate microsphere gel, and application of the sodium hyaluronate microspheregel in cosmetics. The method comprises the following steps: adding dried sodium hyaluronate powder into a hyaluronidase solution, and performing enzymolysis to obtain a sodium hyaluronate small-molecule solution; slowly adding the sodium hyaluronate small-molecule solution into a mixed oil phase, slowly stirring, adding a mixed cross-linking agent of calcium chloride and divinyl sulfone, cross-linking and curing to obtain sodium hyaluronate microspheres; adding the sodium hyaluronate microspheres and pre-treated schizophyllan into an alkaline solution containing polyethylene glycol, uniformlystirring, regulating the pH value of the system to be neutral, adding a phosphate buffer solution, standing and aging, thereby obtaining the schizophyllan modified sodium hyaluronate microsphere gel.The schizophyllan modified sodium hyaluronate microsphere gel prepared by the method disclosed by the invention is small in particle size, easily penetrates into the deep part of skin, can form tiny gel with protein-water, achieves the effect of deeply moisturizing for a long time, and has excellent moisture retention property.

A ceramic heat barrier coating is deposited on a substrate so that the coating has a columnar growth pattern which is interrupted and repeated a number of times throughout its thickness by successive regermination of the ceramic deposit. The regermination is obtained by a vapour phase deposition process wherein a polluting gas is introduced intermittently during the deposition of the ceramic. The resulting ceramic coating has a lower thermal conductivity than conventional columnar ceramic coatings.

The invention discloses a silicon-nitrogen compound as well as a preparation method and application thereof. The structural formula of the silicon-nitrogen compound is as shown in a formula I, wherein X radical is one radical or a combination of radicals selected from pyrazolyl, substituted pyrazolyl, imidazolyl, substituted imidazolyl or amino. The silicon-nitrogen compound disclosed by the invention has a higher vulcanization rate for RTV (Room Temperature Vulcanization) silicon rubber under the room temperature and can be used for providing better heat resistance to the silicon rubber, better bonding strength to the steel and bigger application value.

The invention discloses an escherichia coli detection method based on a time-resolved fluorescence method and DNA hybridization. A capture probe DNA1 and an identifying probe DNA 2 are designed according to a DNA target sequence of escherichia coli; the capture probe DNA1 is fixedly marked on a glass sheet; and the identifying probe DNA 2 is jointed with long-life luminescent rare-earth europium complex. When the capture probe DNA1 and the identifying probe DNA 2 are connected in series and can generate base-pair complementary hybridization reaction with the target DNA (DNA of biology to be detected); and a DNA detection model based on two serial-connected probes on the surface of the glass sheet is established. The long-life luminescent rare-earth europium complex is used as a marker distinguishing the probe DNA 2; and the time-resolved fluorescence method can effectively eliminate the disturbance of fluorescent sources in a biological system and background light of a solid matrix. The detection method takes little time, is visual, flexible, accurate in reaction results and has very obvious advantages.