35 results about "Intrinsic activity" patented technology

In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.

A device and method for cardiac rhythm management in which a cardiac site is paced in accordance with a pacing mode that employs sense signals from a different cardiac site. A protective period triggered by the sensing of intrinsic activity at the paced site is used to delay pacing by a protective delay interval without otherwise disturbing the pacing algorithm.

Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.

A process for producing hydrocarbons comprises providing a multi-tubular reactor having at least 100 tubes units containing a catalyst, each tube being between 2 and 5 meters tall and in thermal contact with a cooling fluid; feeding hydrogen and carbon monoxide to each tube at a linear gas superficial velocity less than about 60 cm / s; and converting the gas feedstream to hydrocarbons on the catalyst, wherein the yield of hydrocarbons in each tube is greater than 100 (kg hydrocarbons) / hr / (m3 reaction zone). Each tube may have an internal diameter greater than 2 centimeters. The catalyst may be active for Fischer Tropsch synthesis and may comprise cobalt or iron. The maximum difference in the radially-averaged temperature between two points that are axially spaced along the reactor is less than 15° C., preferably less than 10° C. The catalyst loading or intrinsic activity may vary along the length of the reactor.

An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.

Provided is a fusion protein comprising, at its carboxy terminal of human erythropoietin (EPO), a mutant having one to four amino acid substitutions in the carboxy terminal peptide (CTP) fragment of a human chorionic gonadotropin (HCG) β subunit, for increasing an in vivo half-life activity of EPO. The in vivo half-life can be greatly elongated while retaining the intrinsic activity of the EPO, without increasing the sugar chain content.

An aggregate of silica particles, which has a primary particle size within a nanometer range, is used as a molecular mold (a dispersion medium). A noble metal compound is adsorbed to the nano-silica aggregate with nanometer order distribution and then reduced to a metallic state. Thereafter, silica particles are dissolved. A noble metal porous body produced in this way has a nano-pore structure with a large specific surface area. The nano-pore structure involves nano-pores as traces of silica particles therein, so as to effectively realize intrinsic activity of a noble metal such as Pd, Pt or Rh. The porous noble metal is useful as functional elements, e.g. catalysts, adsorbents, gas-occluding elements and permselective membranes.

In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.

It has been found that certain antihistamines can mediate the delayed dermatitis and in particular that caused by poison ivy and poison sumac or poison oak. Especially useful are antihistamines having a high degree of intrinsic activity as shown by their low oral dosage as antihistamine (0.1-10, suitably 1-2 mg), which can be topically administered at a sufficiently high active concentration to be effective in the treatment of allergic reactions. Compositions and methods of utilizing such compositions for these purposes are disclosed.

The invention discloses metal-doped CoP3 and a preparation method and application thereof. A cobalt-based precursor doped with different metals and red phosphorus are mixed in a cobalt-phosphorus atomic ratio of (1:3)-(1:4), reacted for 3-5 hours under the vacuum condition of 5*10<-5>-5*10<-4> Pa at the temperature of 625-700 DEG C, and taken out to be soaked into pure CS2 for treatment so as to remove excessive phosphorus, and then the metal-doped CoP3 is obtained. According to the preparation method, CoP3 is doped with the metal elements for the first time, on-site growth of the CoP3 on thesurface of carbon cloth or other flexible materials is achieved, the electrocatalytic intrinsic activity of the CoP3 is improved, the problem that electrocatalyst powder needs to be fixed with naphthol or other polymer adhesives is solved, and the metal-doped CoP3 is suitable for large-scale electrocatalytic industrial hydrogen production.

A device and method for cardiac rhythm management in which a cardiac site is paced in accordance with a pacing mode that employs sense signals from a different cardiac site. A protective period triggered by the sensing of intrinsic activity at the paced site is used to delay pacing by a protective delay interval without otherwise disturbing the pacing algorithm.

An implantable cardiac device and method provides for monitoring a progression or regression in heart disease during an extended time period. A sensor generates an electrogram signal representing electrical activity of a patient's heart. From the generated electrogram signal, a processor determines morphology measurements wherein the morphology measurements indicate a progression or regression in the heart disease. The morphology measurements are stored in a memory during the extended period of time. A telemetry circuit transmits the stored morphology measurements to an external receiver for retrieval or display. The morphology measurements may be of electrogram intrinsic activity or evoked response activity characteristics.

An implantable cardiac stimulation device and associated method capable of delivering non-invasive programmed stimulation for electrophysiological testing in which the onset of the non-invasive programmed stimulation is triggered by a cardiac event, either a detected intrinsic event or a stimulated event, occurring in the heart chamber to be tested. When a non-invasive programmed stimulation command is received by the implanted device, it switches to a routine that allows transition to a non-invasive programmed stimulation from a standard operating mode, during a refractory period. The stimulation device also provides a recovery delay following the last pulse of a non-invasive programmed stimulation sequence. If no intrinsic activity is detected during the recovery delay, a refractory period is started following the expiration of the recovery delay. During this refractory period, a transition from the non-invasive programmed stimulation state machine back to the standard stimulation state machine is accomplished.

The invention belongs to the technical field of hydrogen production materials, and discloses a non-noble metal hydrogen evolution electrocatalyst based on synergistic modification and a preparation method thereof. The catalyst is composed of a metal phosphide active phase, an oxide matrix phase and a carrier, wherein the metal phosphide active phase is dispersedly distributed on the surface of theoxide matrix phase in the form of fine nano-particles, and the oxide matrix phase is loaded on the carrier. According to the invention, the metal phosphide active phase is separated out through a phosphatization reaction and then combined with matrix oxide to construct synergistically catalytic active sites; moreover, the matrix oxide partially reduces the introduced oxygen vacancies, thereby being conducive to improving the electrical conductivity of the matrix material; in addition, when being heated, the precursor material generates a large amount of nano-pores due to dehydration or deamination, thus further improving the mass transfer performance of the catalyst while providing more active sites. Therefore, three factors intrinsic activity, number of active sites and electrical conductivity can be optimized simultaneously. The non-noble metal hydrogen evolution electrocatalyst based on synergistic modification is close to the noble metal Pt catalyst in comprehensive catalytic properties.

An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.

Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.

The invention discloses a multi-level multi-scale tomographic method based on Bayesian estimation. The method comprises for complicated brain source activities of different scales, decomposing abrainsource space into mutually independent voxels, wherein each voxel is used as a potential source of activity; then decomposing all the voxels into regions according to the anatomical structure or functional area of the brain, wherein respective regions correspond to different distribution parameters; in addition, analyzing the out-of-brain sampling data by using a method based on Bayesian and its convex function theory, and estimating the intrinsic activity distribution of all voxels and the covariance components of regional activity distribution. Based on the above model framework, two methodsare provided, wherein one method is that the covariance component of the final activity of the voxels is determined only by the regional activity and is called tling-Champagne, and the other method is that the activity of the voxels is determined by the intrinsic activity of the voxels and the regional activity distribution and is called tree-Champagne. Finally, the performance analysis is carried out by simulation data and real brain data, and good effects are obtained.

The electrocatalytic compositions of this invention comprise a platinum-based electrocatalyst and polyvinylpyrrolidone (PVP), whereby the PVP improves certain properties of the platinum-based electrocatalyst. The electrolytic compositions described herein have applications in fuel cell technologies. The polymer-modified platinum-based electrocatalyst compositions exhibit an enhanced long-term CO tolerance with a small hindrance to the intrinsic activity of the platinum based electrocatalyst. Furthermore, the electrocatalytic compositions demonstrate improved catalyst stability.

A method of enhancing the intrinsic activity of an enzyme in a raw enzyme solution, the method comprising treating the raw enzyme solution with an effective amount of a purifying agent, most preferably, activated carbon, to effect the enhancement and provide an enzyme solution of enhanced activity. Preferred enzymes are amylase, glucoamylase, cellulase, xylanase, and all other group 3 hydrolases.

The present invention relates to a microorganism with improved production of 5′-xanthosine monophosphate and 5′-guanine monophosphate, and more specifically, to a Corynebacterium sp. microorganism having increased proline dehydrogenase activity compared with an intrinsic activity thereof, a method for producing 5′-xanthosine monophosphate or 5′-guanine monophosphate from the culture medium obtained by culturing the transformed microorganism, and a use of the microorganism for production of 5′-xanthosine monophosphate or 5′-guanine monophosphate.

An implantable cardiac stimulation device promotes intrinsic activity of a heart during demand pacing. The device increases the time and probability of an AV delay interval extension. The device may further increase the AV delay interval from a first extended AV delay interval to a longer second extended AV delay interval. The device may further encourage intrinsic AV conduction in patients with intact AV conduction by allowing multiple cycles during a search interval and multiple search times to further encourage intrinsic conduction from the atrium to the ventricle.

The invention belongs to the technical field of functional nano-materials. The invention discloses a preparation method of concave type hollow platinum-palladium nanocrystal. The synthetic method comprises the following steps: concave palladium nanocrystal is used as a template to uniformly deposit a platinum nano-shell layer; and through a selective chemical etching method, a palladium core is removed to obtain the concave type hollow platinum-palladium nanocrystal. The invention also discloses the concave type hollow platinum-palladium nanocrystal and application thereof. By the method of the invention, the concave type hollow platinum-palladium nanocrystal is obtained successfully. The synthetic process is simple, the synthetic condition is mild, and the synthetic method is suitable forlarge-scale preparation. The concave type hollow platinum-palladium nanocrystal is hollow platinum-palladium nanocrystal with the outermost layer being a high-index crystal plane. According to the nanocrystal, utilization rate is raised, and intrinsic activity of the platinum surface also can be greatly increased. The prepared catalyst and the synthetic process can meet the requirements of a fuelcell cathode catalyst, and are helpful for promoting industrialization of fuel cells.

A system for treating abnormal muscle activity via energy application includes a catheter, an electrode assembly including a plurality of electrodes, a processor configured to receive signals associated with intrinsic tissue activity sensed by the plurality of electrodes, the processor determining a location of a target tissue to be treated based on the sensed intrinsic activity, and a stimulator configured to transmit energy to at least one of the plurality of electrode located at the target tissue.

The present invention relates to a polynucleotide that is active to an acetyl glutamate synthase and acetyl ornithinase which are associated with ornithine or arginine biosynthesis from Corynebacterium glutamicum. The present invention also relates to a polypeptide encoded by said polynucleotide, a recombinant vector comprising said polynucleotide, to a transformant obtained by introducing said recombinant vector to a host microorganism for producing L-ornithine or L-arginine, and transforming the recombinant vector, and to a method for producing L-ornithine or L-arginine by culturing said transformant. The activity of the transformant of the present invention to an acetyl glutamate synthase and acetyl ornithinase is increased as compared to an intrinsic activity, and thus L-ornithine or L-arginine can be produced, at a high yield rate, from the transformant of the present invention.

The invention relates to the field of hydrotreating catalysts, and discloses a hydrotreating catalyst, a preparation method and applications thereof. The preparation method comprises: 1) impregnatingan alumina carrier with a sulfur-nitrogen-containing organic compound solution to obtain an impregnated product; 2) carrying out low-temperature drying treatment on the impregnated product obtained inthe step 1); and 3) impregnating the alumina carrier treated in the step 2) with an active component solution, and carrying out heat treatment, wherein the temperature of the low-temperature drying treatment is 15-180 DEG C, and the temperature of the heat treatment is 180-550 DEG C. According to the present invention, the catalyst prepared by the method has good matching between the dispersion degree and the sulfurization, and more active sites are generated, such that the intrinsic activity of the catalyst is easily improved; and the preparation method is simple, and the production cost islow.

The invention provides preparing method of the dual targets effect gene mosaic recombinant and application. The method comprises the following steps: using the SDF-54 / R / pET-30a(+) as match plate, augmenting the SDF-54 / R with specificity primer, entering the SDF-54 / R into T-A clone carrier, then in the 3'-SDF-54 / R joining the butt hinge coded sequence of human IgG1 heavy chain antibody and Decorin mature peptide coded sequence, and constructing the SDF-54 / R-IgG1HCHR-Decorin / pMD18-T recombination mosaic. The SDF-54 / R-IgG1HCHR-Decorin keeps the affinity of CXCR4 and losses the intrinsic activity, and suppresses the chemotaxis and transfer activity of wild-type SDF-1ª‡ to breast cancer cell and the growth of breast cancer cell. It can be used as CXCR4 antagonist, at the same time suppressing the growth and transfer of CXCR4 positive tumour cell. So it possesses the dual targets effect.